CAS: 69558-55-0; (6S,9S,12S,15S,18S)-1,6-Diamino-9-(4-Aminobutyl)-12-(Carboxymethyl)-18-(4-Hydroxybenzyl)-1-Imino-15-Isopropyl-7,10,13,16-Tetraoxo-2,8,11,14,17-Pentaazanonadecan-19-Oic Acid

上下游产品

CAS号158899-11-7 Fm°C-Arg (B°C)2-OH | CAS号68858-20-8 Fm°C-L-缬氨酸 | CAS号71989-14-5 Fm°C-L-天冬氨酸-4-叔丁酯 | CAS号71989-38-3 Fm°C-O-叔丁基-L-酪氨酸 | CAS号71989-26-9 Nα-芴甲氧羰基-Nε-叔丁氧... | CAS号13726-76-6 N(α)-B°C-L-精氨酸 | CAS号126513-33-5 Cbz-Arg(HCl)-Ly... | CAS号143824-77-5 N-芴甲氧羰基-N',N''-...

(3S)-3-[[(2S)-6-Amino-2-[[(2S)-2-Amino-5-(Diaminomethylideneamino)Pentanoyl]Amino]Hexanoyl]Amino]-4-[[(2S)-1-[[(2S)-1-[(4-Diphenylphosphorylphenyl)Methoxy]-3-(4-Hydroxyphenyl)-1-Oxopropan-2-Yl]Amino]-3-Methyl-1-Oxobutan-2-Yl]Amino]-4-Oxobutanoic Acid置于palladium On Activated Charcoal,氢气体系中,用 甲醇 作为反应溶剂,20.0 °C,482.64 Kpa 条件下,反应 24.0H,以87%的收率获得产物胸腺五肽
参考文献:通过设计 Gap 保护基团合成 Gap 肽:不含聚合物,色谱和重结晶的胸腺五肽 Fmoc/tbu 合成
标题:通过设计 Gap 保护基团合成 Gap 肽:不含聚合物,色谱和重结晶的胸腺五肽 Fmoc/tbu 合成
摘要:报道了一种新的 Fmoc/tbu 液相肽合成方法和一种新的苄基型 Gap 保护基团的开发.这种新的 Gap 保护基团用于代替聚合物载体,促进 C->n Fmoc 肽合成,无需色谱,重结晶或聚合物载体.gap基团可以高收率加入和去除,用于合成超过1克的免疫刺激剂胸腺五肽,总收率(83%)和纯度(99%).
DOI:10.1002/ejoc.201600026

专利信息

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-7122693-B2
优先权日:1988-04-11
标题 :Acetaldehyde acetal compounds, their synthesis, and uses thereof
发明人：BELLEAU EXECUTRIX OF ESTATE PI; DIXIT DILIP M; NGUYEN-BA NGHE
权利人:SHIRE BIOCHEM INC
摘要:The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.

专利号:US-5219988-A
优先权日:1989-02-22
标 题 :Gem-diamino derivatives and their use in the synthesis of retro-inverso peptides
发明人：GAZERRO LAURA; PINORI MASSIMO; VERDINI ANTONIO S
权利人:ENIRICERCHE SPA; SCLAVO SPA
摘要:This invention relates to new gem-diamino derivatives of general formula (I) ##STR1## where R is the side chain of an amino acid, of which any functional groups are suitably protected, and n X is an acyl group chosen from the group consisting of 2-nitrobenzoyl, 4-chloro-butyryl, acetoacetyl, 4-bromo-butyryl, (2-nitrophenoxy)-acetyl and 2-methyl-2-(2'-nitro-phenoxy)propionyl, of use in introducing gem-diamino residues into retro-inverso peptides. The invention further relates to a method for the synthesis of retro-inverso peptides in which the gem-diamino residue or residues are introduced using the new compound (I).

专利号:US-5962515-A
优先权日:1997-05-29
标题 :Process for isolation and synthesis of 1-(3,4 methylenedioxy-phenyl)-1E-tetradecene and its analogues and their activities against tumors and infections
发明人：UPADHYAY SHAKTI N; VISHWAKARMA RAM A; GHOSAL SABARI; SHUKLA SUPRIYA; BOSE CHANDA; KAMRA ANITA
权利人:NAT INST IMMUNOLOGY
摘要:Process for isolation of 1-(3,4-methylenedioxy-phenyl)-1E-tetradecene from Piper longum. Processes for synthesis of 1-(3,4-methylenedioxy-phenyl)-1E-tetradecene; its stereoisomers and analogues are disclosed. The compounds isolated and synthesized according to this invention have immunomodulatory properties and can be used to treat tumors and infections.

专利号:US-2010261876-A1
优先权日:2007-09-25
标 题:Novel methods of synthesis for therapeutic antiviral peptides
发明人：BRAY BRIAN L; JOHNSTON BARBARA E; SCHNEIDER STEPHEN E; TVERMOES NICOLAI A; ZHANG HUYI; FRIEDRICH PAUL E
权利人:BRAY BRIAN L; JOHNSTON BARBARA E; SCHNEIDER STEPHEN E; TVERMOES NICOLAI A; ZHANG HUYI; FRIEDRICH PAUL E
摘要:Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.