CAS: 1020174-04-2; 1-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-Pyrazole

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上下游产品

CAS号269410-08-4 4-吡唑硼酸频哪醇酯 | CAS号74-88-4 碘甲烷 | CAS号844501-71-9 吡唑-3-硼酸频哪醇酯

4-吡唑硼酸频哪醇酯,碘甲烷置于potassium Tert-Butylate体系中,用 四氢呋喃,N,N-二甲基甲酰胺 用作溶剂,化学反应 1.17H,反应生成1-甲基吡唑-3-基-硼酸频哪醇酯
参考文献: 4,6-Disubstituted 2-Amino-Pyrimidines As Histamine H4 Receptor Modulators[fr] 2-Amino-Pyrimidines 4,6-Disubstituées,Convenant Comme Modulateurs Du Récepteur H4 De L'Histamine
标题: 4,6-Disubstituted 2-Amino-Pyrimidines As Histamine H4 Receptor Modulators[fr] 2-Amino-Pyrimidines 4,6-Disubstituées,Convenant Comme Modulateurs Du Récepteur H4 De L'Histamine
摘要:本发明涉及式(i)的取代杂环化合物或其药用可接受的盐或n-氧化物或季铵盐,其中所述成员在此提供,并且它们的组合物和使用方法,这些化合物是组织胺h4受体抑制剂/拮抗剂,用于治疗组织胺h4受体相关疾病或疾病或疾病,例如,炎症性疾病或疾病,瘙痒和疼痛.

专利信息

专利号:US-12428395-B2
优先权日:2019-08-01
标题 :Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：PENDHARKAR DHANANJAY; RAMACHANDRAN SREEKANTH A; JADHAVAR PRADEEP S; PANPATIL DAYANAND; SAEED UZMA; KUMAR VIVEK; BIST DIPSHE
权利人:SPEROGENIX THERAPEUTICS LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.