合成目标产物 2-Furanboronic Acid 主要起始原料 2-(Furan-2-yl)-6-Methyl-1,3,6,2-Dioxazaborocane-4,8-Dione, 2-Furanboronic Acid Mida Ester
(文献来源)合成步骤主要原料 2-(Furan-2-yl)-6-Methyl-1,3,6,2-Dioxazaborocane-4,8-Dione, 2-Furanboronic Acid Mida Ester
2-Furanylboronic Acid Mida Ester置于sodium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,化学反应 0.33H,以95%的收率获得2-呋喃硼酸 参考文献:Knapp,David M.; Gillis,Eric P.; Burke,Martin D.,Journal Of The American Chemical Society,2009,Vol. 131,P. 6961-6963 标题:Knapp,David M.; Gillis,Eric P.; Burke,Martin D.,Journal Of The American Chemical Society,2009,Vol. 131,P. 6961-6963
专利信息
专利号:US-2022356182-A1 优先权日:2009-03-27 标题 :Inhibitors of hepatitis c virus replication 发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-7176230-B2 优先权日:2004-11-16 标题 :Synthesis of indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) as anti-platelet agents 发明人:KUO SHENG-CHU; LEE FANG-YU; HUANG TSANG-MIAO; TENG CHE-MING; LEE ON; WU CHIN-YI; HWANG CHRONG-SHIONG; HUNG CHI-YING 权利人:YUNG SHIN PHARM IND CO LTD 摘要:The present invention synthesizes a series of novel indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole (YC-1), and their anti-platelet activity.
专利号:US-7960589-B2 优先权日:2006-09-06 标 题:Synthesis of sphingosines and their derivatives 发明人:YANG HAO; LIEBESKIND LANNY S 权利人:UNIV EMORY 摘要:Embodiments of the present disclosure provide for methods of making sphingosines and derivatives thereof, and the like.
专利号:US-11053243-B2 优先权日:2009-03-27 标 题:Inhibitors of hepatitis C virus replication 发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-9090661-B2 优先权日:2009-03-27 标 题:Inhibitors of hepatitis C virus replication 发明人:COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:WO-03000690-A1 优先权日:2001-06-25 标题:Synthesis of heterocyclic compounds employing microwave technology 发明人:MAJID TAHIR NADEEM; DEPRETS STEPHANIE D; PEDGRIFT BRIAN L 权利人:AVENTIS PHARMA INC; MAJID TAHIR NADEEM; DEPRETS STEPHANIE D; PEDGRIFT BRIAN L 摘要:This invention provides for processes for preparing compounds of the formula (I) comprising employing microwave energy.