CAS: 137052-08-5; 1-(Tetrahydro-2H-Pyran-4-yl)Ethanone

相似化合物

66956-74-9 156353-01-4 7464-18-8

上下游产品

四氢吡喃-4-甲酸 Tetrahydropyran-4-Carboxylic Acid 01/03/5337

N-甲氧基-N-甲基四氢吡喃-4-羧酰胺置于甲基溴化镁体系中,用 四氢呋喃,乙酸乙酯 用作溶剂,化学反应生成1-(四氢-2H-吡喃-4-基)乙酮
参考文献:Pentafluorosulfur Imino Heterocyclic Compounds As Bace-1 Inhibitors,Compositions And Their Use
标题:Pentafluorosulfur Imino Heterocyclic Compounds As Bace-1 Inhibitors,Compositions And Their Use
摘要:在它的许多实施例中,本发明提供了特定的五氟硫酰亚胺杂环化合物,包括式(a)的化合物及其药学上可接受的盐.式(a)的化合物具有以下一般结构:(a),其中每个变量是独立选择且如此定义的.本发明还揭示了包含一个或多个此类化合物(单独和与一个或多个其他活性剂的组合)的制药组合物,并用于治疗与淀粉样β(aβ)蛋白相关的病理状况,包括阿尔茨海默病的方法.

专利信息

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:WO-2025081713-A1
优先权日:2023-10-16
标 题:Method for preparing hydrazine compound
发明人：HONG HAO; JAMES GAGE; ZHANG NA; JIAO XUECHENG; LI YANJUN; HUANG AIPING; SHEN PEILI; SHI CHENGCHENG; MA TIANJIAO
权利人:JILIN ASYMCHEM PHARMACEUTICALS CO LTD; TIANJIN ASYMCHEM BIOTECHNOLOGY CO LTD
摘要:A method for preparing a hydrazine compound. The method comprises: using an imine reductase to catalyze a reduction reaction between a substrate ketone compound as shown in formula I or formula III and a substrate hydrazine compound as shown in formula II, to obtain a product hydrazine compound. The imine reductase is used to perform the synthesis of the hydrazine compound, the synthesis process is simple and economical, various hydrazine compounds can be directly synthesized, and fewer substituent groups are present on the N atoms of the resulting hydrazine compounds. In addition, the method can be used for industrial amplification, is low in cost and high in purity, and achieves true green chemistry.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-2018222892-A1
优先权日:2012-07-03
标 题 :Heterocyclic modulators of lipid synthesis

专利号:EP-3083583-B1
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof

专利号:CA-2934251-A1
优先权日:2013-12-20
标题:A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer