CAS: 162558-25-0; Fmoc-Dap(Boc)-Oh

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(S)-3-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-5-Oxo-4-Oxazolidineacetic Acid置于n-甲基吗啉,Lithium Hydroxide,Sodium Azide体系中,用 四氢呋喃,甲苯 用作溶剂,化学反应 0.75H,反应生成N-Fmoc-N'-Boc-L-2,3-二氨基丙酸
参考文献:Practical And Efficient Synthesis Of Orthogonally Protected α‐2,3‐diaminopropionic Acid (2,3‐dap),2,4‐diaminobutanoic Acid (2,4‐dab),And Their N‐methylated Derivatives
标题:Practical And Efficient Synthesis Of Orthogonally Protected α‐2,3‐diaminopropionic Acid (2,3‐dap),2,4‐diaminobutanoic Acid (2,4‐dab),And Their N‐methylated Derivatives
摘要:
Doi:10.1080/00397910600772827

专利信息

专利号:US-8569452-B2
优先权日:2011-02-17
标题:Preparation of phalloidin and its derivatives
发明人：LIU BAOSHENG; ZHANG JIANHENG
权利人:LIU BAOSHENG; ZHANG JIANHENG; AMERICAN PEPTIDE COMPANY INC
摘要:The present invention relates to novel phalloidin derivatives and their fluorescent dye conjugates. These new compounds may be used in studies of actin dynamics in living systems. The present invention also relates to methods for preparing such compounds. The synthesis routes combine solid-phase and solution phase peptide synthesis, and has great advantage for efficient preparation of a diverse library of the phalloidin derivatives, especially for the synthesis of phalloidin.

专利号:US-11279734-B2
优先权日:2017-12-01
标 题:Solution-phase affinity selection of inhibitors from combinatorial peptide libraries
发明人：PENTELUTE BRADLEY L; TOUTI FAYCAL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides novel peptides (e.g., peptides, macrocyclic peptides, mini-proteins) that modulate protein-protein interactions or salts thereof, and methods of making and using the inventive peptides. In some embodiments, the peptides are high affinity inhibitors (e.g., K D of at most 100 nM, at most 10 nM, at most 1 nM) of a protein-protein interaction. In certain embodiments, these peptides interfere with p53-MDM2 binding interactions (e.g., by binding to MDM2 (GenBank® Gene ID: 4193)). In some embodiments, the peptides interfere with the dimerization of the C-terminal domain of the human immunodeficiency virus (HIV) capsid protein (C-CA), comprising residues 146-231 of the HIV capsid protein (e.g., by binding to the C-terminal domain of the HIV capsid protein (C-CA), thereby inhibiting the dimeric interface of HIV capsid protein, thereby inhibiting viral assembly). These inventive peptides were rapidly generated and identified using novel methods described herein comprising combinatorial peptide synthesis and/or solution affinity selection.

专利号:US-2024327456-A1
优先权日:2021-07-07
标题 :Cancer therapeutics
发明人：AGELL JANE NIEVES; JAUMOT PIJOAN MONTSERRAT; CABOT ROMERO DEBORA; BRUN LOZANO SONIA; ABUASAKER BARAA; RABANAL ANGLADA FRANCESC; PALLARA CHIARA; SECO MORAL JESUS; RIVAS SANTOS JOSEP; PRADES COSANO ROGER; TARRAGO CLUA TERESA
权利人:UNIV BARCELONA
摘要:Therapeutic compounds of the invention comprise peptidomimetics, including those of formula (I), which has been prepared using solid-phase peptide synthesis. It is useful in the treatment of a cancer, including, for the treatment of a pancreatic cancer, a lung cancer or a colorectal cancer, further, including, a treatment for a pancreatic ductal adenocarcinoma.

专利号:WO-2009000950-A1
优先权日:2007-06-25
标题:Method for the deblocking/deprotection of compounds obtained by solid phase synthesis