CAS: 165253-31-6; (Tetrahydrofuran-3-yl)Methanamine

相似化合物

184950-35-4 1048962-84-0 1048962-82-8

上下游产品

3-cyanotetrahydrofuran 2-(tetrahydrofuran-3-ylmethyl)-isoindole-1,3-dione N-[(oxolan-3-yl)methylidene]hydroxylamine 2-nitromethyl-1,4-diethyl succinate (2S,4S,5S,7S)-5-azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid [3(R)- and 3(S)-(tetrahydro-furan-3-ylmethyl)]-amide N-(1-methyl,-2-{[(tetrahydrofuran-3-ylmethyl)amino]methyl}-1H-indol-5-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide N-(1-methyl-2-{[(tetrahydrofuran-3-ylmethyl)amino]methyl}-1H-indol-5-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

3-氰基-四氢呋喃置于氢气,镍体系中,用 叔丁醇 用作溶剂,50.0 °C,50.67 Kpa 条件下,反应 10.0H,以95 G的收率获得3-氨基甲基-四氢呋喃
参考文献:一种四氢呋喃-3-甲胺的合成方法
标题:一种四氢呋喃-3-甲胺的合成方法
摘要:本发明公开了一种四氢呋喃‑3‑甲胺的合成方法,解决了现有技术中四氢呋喃‑3‑甲胺的合成具有路线过程繁琐,成本较高,反应条件苛刻的问题.本发明包括:(1)在有机溶剂i中,丙烯腈和环氧乙烷在催化剂a存在的条件下反应生成3‑氰基‑四氢呋喃;(2)3‑氰基‑四氢呋喃纯化后在有机溶剂ii和催化剂b条件下还原得到四氢呋喃‑3‑甲胺.本发明大大缩短了工艺流程和生产周期,原料简单易得,绿色环保,成本低,操作简单,收率高,具有显著的社会经济效益和商业应用价值.

专利信息

专利号:US-7179918-B2
优先权日:2001-06-11
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-7094909-B2
优先权日:2001-06-11
标 题 :HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:AGOURON PHARMA
摘要:The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, n nwhich are useful as inhibitors of the HIV protease enzyme.

专利号:CN-111659426-B
优先权日:2020-06-18
标 题 :A γ-alumina modified catalyst, its preparation method and its application in the synthesis of 2,5-dihydrofuran

专利号:WO-2024179572-A1
优先权日:2023-03-01
标题:Aromatic-ring compound and use thereof
发明人：LI JIN; WANG QINGYANG; WANG XIAOTAO; LI XIAOMEI; DOU DENGFENG; MENG XIAOYUN; LI XIANYANG; CHEN QIUXIA; GUO ANPING; Zheng nuo; HU HONG; HE WEI
权利人:HITGEN INC
摘要:Provided are a new compound having a binding effect on the E3 ligase protein TRIM21, and the use thereof in the preparation of a drug for treating abnormal cell proliferation diseases. Further provided is an intermediate compound in the synthesis process of a proteolysis-targeting bifunctional compound.

专利号:WO-2012122391-A1
优先权日:2011-03-08
标 题 :Heterocyclic modulators of lipid synthesis

专利号:CN-107118184-B
优先权日:2017-06-27
标题:Novel synthesis process of tetrahydrofuran-3-methylamine