CAS: 2905-25-1; 2-Bromobenzenesulphonyl Chloride

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CAS号615-36-1 2-溴苯胺 | CAS号146335-10-6 1-bromo-2-[(met... | CAS号244205-40-1 2-溴苯硼酸 | CAS号108-86-1 溴苯 | CAS号352615-90-8 2-磺酰基-联苯-4-羧酸 | CAS号3466-80-6 2-苯基哌啶 | CAS号92748-09-9 2-溴苯磺酰胺 | CAS号951883-94-6 2-溴-N-异丙基苯磺酰胺 | CAS号936-44-7 3-苯基-吡咯烷 | CAS号929000-58-8 1-(2-溴苯基磺酰基)吡咯烷 | CAS号951883-92-4 2-溴-N-丙基苯磺酰胺 | CAS号932-96-7 4-氯-N-甲基苯胺 | CAS号98192-14-4 2-溴-N-甲基苯磺酰胺 | CAS号65000-12-6 2-溴-N,N-二乙基苯磺酰胺

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于五氯化磷体系中,化学反应生成2-溴苯磺酰氯
参考文献:Berndsen; Limpricht,Justus Liebigs Annalen Der Chemie,1875,Vol. 177,P. 101
标题:Berndsen; Limpricht,Justus Liebigs Annalen Der Chemie,1875,Vol. 177,P. 101

专利信息

专利号:US-2025188046-A1
优先权日:2023-12-08
标题:Ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent sufex connections via lithiated chemistry
发明人：KIM DONG-PYO; KANG JI-HO
权利人:POSTECH RES & BUSINESS DEV FOUND
摘要:Disclosed are ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent SuFEx connections via lithiated chemistry. In detail, a method of synthesizing an ortho-functionalized benzenesulfonyl fluoride derivative, the method comprises (a) reacting a benzenesulfonyl fluoride derivative represented by structural formula 1 with an organolithium represented by structural formula 2, thus synthesizing an intermediate represented by structural formula 3 in reaction scheme 1 and (b) reacting the intermediate with an electrophile, thus synthesizing a compound represented by structural formula 4 or a compound represented by structural formula 4′. The present disclosure enables the synthesis of several functionalized sulfonyl fluorides within a few seconds under mild temperature conditions in addition to the chemistry of Sulfonyl Fluoride Exchange (SuFEx), which is a next-generation click chemistry, so that sulfonyl fluoride, the main reactant of the SuFEx reaction, can be efficiently secured.

专利号:US-6388083-B2
优先权日:2000-07-07
标题 :Process for the synthesis of (2S)-phenyl-3-piperidone
发明人：LEE JAEMOON; ASKIN DAVID; HOANG THOA
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2S)-phenyl-3-piperidone. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-7439364-B2
优先权日:2001-05-17
标 题 :Process for the synthesis of derivatives of halo-[2,3-F] quinoline
发明人：CHAN ANITA W; CURRAN TIMOTHY T; IERA SILVIO; CHEW WARREN; SELLSTEDT JOHN H; VID GALINA; FEIGELSON GREG; DING ZHIXIAN
权利人:WYETH CORP
摘要:Methods of preparing compounds of Formula I n nare provided.

专利号:WO-2014170910-A1
优先权日:2013-04-04
标 题:Process for the preparation of lapatinib
发明人：MUDDASANI PULLA REDDY; TALASILA SAMBASIVA RAO; SATTI VENKATA REDDY; NEKKANTI SATISH CHOWDARY; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD
摘要:Present process relates to an improved and commercial process for the preparation of lapatinib of formula-I or its pharmaceutically acceptable p-toluenesulfonate salt involving novel intermediates of formulae-XVII, XVIII, and XIX. Present process utilizes Meerwein reaction as a key step in the aryl C-C bond formation step avoiding costly boronate coupling chemistry used in the conventional synthesis of lapatinib.

专利号:US-6943254-B2
优先权日:1997-03-07
标 题 :Synthesis of pyrazinyl pyridine-3-sulfonamide compounds
发明人：HOGAN PHILIP JOHN
权利人:ASTRAZENECA UK LTD
摘要:A process for the manufacture of: n n nwherein R is (1-4C)alkyl, carboxyl(1-4C)alkyl or 1,3,4-oxadiazol-2-yl comprises:n (a) reaction of the diazonium salt of 3-amino-2-chloropyridine with thionyl chloride in water and an electron transfer catalyst; (b) reaction with isobutyl-(3-methoxy-5-methylpyrazin-2-yl)carbamate and an alkali metal hydride in inert solvent; and (I) where R is (1-4C)alkyl, carboxy(1-4C)alkyl: (c) reaction with a boronic acid: n n (or an anhydride or ester therof) in the presence of a base and a palladium or nickel catalyst in solvent; and removal of the isobutoxy carbonyl group; or (ii) where R is 1,3,4-oxadiazol-2-yl (c) reaction with 4-methoxycarbonylphenylboronic acid (or an anhydride or ester thereof) with a source fluoride ion under aqueous conditions; (d) removal of the isobutoxycarbonyl protecting group; (e) conversion of the methyl ester group to the hydrazide; and (f) conversion to a 1,3,4-oxadiazol-2-yl moiety.

专利号:US-2002187983-A1
优先权日:2001-05-17
标 题:Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline