CAS: 513-38-2; Isobutyl Iodide

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CAS号78-83-1 异丁醇 | CAS号603-35-0 三苯基膦 | CAS号79-29-8 2,3-二甲基丁烷 | CAS号78-77-3 溴代异丁烷 | CAS号513-36-0 氯代异丁烷 | CAS号108-08-7 2,4-二甲基戊烷 | CAS号115-11-7 2-甲基丙烯 | CAS号556-56-9 烯丙基碘 | CAS号593-71-5 氯碘甲烷 | CAS号1068-55-9 异丙基氯化镁 | CAS号30762-00-6 4-异丁氧基苯甲酸 | CAS号542-56-3 亚硝酸异丁酯 | CAS号625-74-1 2-甲-1-硝丙烷 | CAS号32741-05-2 2-异丁基噻吩 | CAS号38861-88-0 4-异丁基苯甲酸 | CAS号583-48-2 3,4-二甲基己烷 | CAS号507-20-0 氯代叔丁烷 | CAS号513-36-0 氯代异丁烷 | CAS号4006-38-6 二异丁基膦 | CAS号4125-25-1 三异丁基磷烷

异丁醇置于咪唑,碘,三苯基膦体系中,化学反应生成 碘代异丁烷
参考文献:通过铱催化的c 进行芳烃的立体控制烷基化 H硼化
标题:通过铱催化的c 进行芳烃的立体控制烷基化 H硼化
摘要:互补化学:报道了一种通过空间效应控制芳烃的位点选择性烷基化的单锅法.发生的过程通过铱催化的ç  ħ硼基化,随后pd或ni基催化的亲电子烷基偶联.这种选择性补充了典型的friedel-Crafts烷基化反应的选择性.元的宽范围的各种电子性质和官能团的芳烃-选择性的烷基化发生在非常好的产率与部位选择性高.
DOI:10.1002/anie.201208203

专利信息

专利号:US-7173059-B2
优先权日:2003-05-08
标题:Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same
发明人：ALBIZATI KIM FRANCIS; BABU SRINIVASAN
权利人:AGOURON PHARMA
摘要:Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are disclosed.

专利号:US-6472534-B2
优先权日:1999-10-21
标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
发明人：BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K
权利人:AGOURON PHARMA
摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.

专利号:US-9346851-B2
优先权日:2008-02-22
标 题 :Chemical modification of proteins
发明人：BERNARDES GONCALO; CHALKER JUSTIN; DAVIS BENJAMIN
权利人:BERNARDES GONCALO; CHALKER JUSTIN; DAVIS BENJAMIN; RP SCHERER TECHNOLOGIES LLC
摘要:The invention relates to methods for selectively converting a cysteine residue in a peptide or protein to the dehydroalanine (Dha) residue. The method also works on selenocysteine and substituted cysteine and selenocysteine residues, resulting in the Dha residue which may be converted to any natural or unnatural amino acid residue desired without the alteration of the remainder of the peptide or protein. The invention also allows ligation of a desired peptide at any point rather than at a point where there should be a naturally occurring cysteine, thereby allowing native chemical ligation to be used in the synthesis of peptides that do not contain cysteine. The methodology allows for the synthesis of very large peptides.

专利号:US-4033949-A
优先权日:1976-04-14
标 题:Analogs of thromboxane B2 and processes for their synthesis
发明人：KELLY ROBERT C; NELSON NORMAN A
权利人:UPJOHN CO
摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-11a-oxa-PGF 2 .sub.α). These analogs are particularly and especially useful as reproductive cycle control agents.

专利号:WO-2014108526-A1
优先权日:2013-01-11
标题 :Synthetic process for the manufacture of pipecolidepsin compounds
发明人：PELAY GIMENO MARTA; GARCà A-RAMOS YESICA; TULLA PUCHE JUDIT; ALBERICIO PALOMERA FERNANDO; MARTà N LÓPEZ M JES S
权利人:PHARMA MAR SA
摘要:(I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , n and Y are as described. The invention provides a process for the synthesis of complex pipecolidepsin and related compounds of formula (I), opening a new field of compounds with useful biological properties. The invention also provides intermediates, useful in the synthesis of compounds of formula (I).

专利号:US-2009143426-A1
优先权日:2007-12-04
标 题:Synthesis of 1,3,6-trisubstituted-2-carboxyquinol-4-ones as selective ET A antagonists and their use as medicaments
发明人：STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN
权利人:STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN
摘要:The invention discloses the composition and preparation of various 1,3,6-trisubstituted-2-carboxy-quinol-4-ones of the formula 1 where R is H, alkyl, haloalkyl or hydroxyalkyl, R′ is alkyl, nitro, halogen or NR 2 ′″ where R′″ is alkyl or cycloalkyl, and R″ is H or alkyl. The composition of the invented compounds as methods of antagonizing the action of endothelin-1 to treat cardiovascular, pulmonary diseases and obstetric disorders and preterm labor and preeclampsia in mammals is disclosed.