CAS: 648449-76-7; 5-((2,2-Difluorobenzo[d][1,3]Dioxol-5-yl)Methylene)Thiazolidine-2,4-Dione

专利信息

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:WO-2024213057-A1
优先权日:2023-04-12
标题:Use of combination of lsd1 inhibitor and drug to treat cancer
发明人：LIU HONG; LI JIA; HUANG HE; WANG JIANG; ZHOU YUBO; REN XUELIAN; LI CHUNPU; KAN WEIJUAN; XU ZICHAO; HU XIAOBEI; WU HENGBO; WANG HANLIN; YE YUNFEI; QIU XIAOHUI; SU MINGBO
权利人:SHANGHAI INST MATERIA MEDICA CAS
摘要:A use of a combination of an LSD1 inhibitor and a drug to treat cancer. Specifically, provided is a composition comprising: a tranylcypromine compound and/or a derivative thereof; and a drug selected from a kinase inhibitor, an anti-cancer drug acting upon or affecting the DNA, an antiviral compound, an antihypertension compound, an antidiabetic compound, a JAK-STAT signaling pathway inhibitor, an NF-κB signaling pathway inhibitor, a protein synthesis inhibitor, a 5-hydroxytryptamine receptor agonist, a dystroglycan modulator, a GABA receptor modulator, or a combination thereof. The two active ingredients have a synergistic effect, and the synergistic treatment effect is significantly better than that of the two individually, thereby remarkably improving the cancer treatment effect.