CAS: 656-65-5; 4-Bromo-3-Fluoroaniline

上下游产品

N-(4-bromo-3-fluorophenyl)ethanamide meta-fluoroaniline N-(3-fluorophenyl)acetamide 4-bromo-3-fluorobenzonitrile (E)-N-(4-bromo-3-fluorophenyl)-2-(oximido)acetamide N-(4-bromo-3-fluoro-phenyl)-N'-phenyl-ureaN-(4-bromo-3-fluoro-phenyl)-N'-phenyl-urea 4-bromo-3-fluoroiodobenzene 4-(4-amino-2-fluorophenyl)-1-isoindolinone

4-溴-3-氟苯腈置于双氧水,Sodium Hydroxide,Sodium Hypochlorite体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 10.0H,以79%的收率获得产物4-溴-3-氟苯胺
参考文献:一种磷酸特地唑胺中间体3-氟-4-溴苯胺的合成方法
标题:一种磷酸特地唑胺中间体3-氟-4-溴苯胺的合成方法
摘要:本发明提供了一种磷酸特地唑胺中间体3‑氟‑4‑溴苯胺的合成方法,该方法包括以下步骤:(1)化合物1与氨气反应,得到化合物2;(2)化合物2与氢溴酸反应,得到化合物3;(3)化合物3中的氰基被还原成氨基,得到化合物4.本发明的方法采用的原料廉价易得,反应条件温和,设备要求简单,安全指数高,适合大规模商业化生产.利用本发明的工艺制得的磷酸特地唑胺中间体3‑氟‑4‑溴苯胺收率高达56.61%以上,纯度高达99.70%以上,产品中异构体杂质的含量低至0.17%以下.本发明为磷酸特地唑胺原料药商业化生产提供了价廉易得的高品质中间体,应用前景广阔.

专利信息

专利号:WO-2023122754-A1
优先权日:2021-12-23
标 题 :Processes and intermediates for preparing gb13, gb22 and himgaline
发明人：LANDWEHR ELEANOR; SHENVI RYAN; BAKER MEGHAN; OGUMA TAKUYA
权利人:SCRIPPS RESEARCH INST
摘要:Provided herein are processes for the streamlined synthesis of Galbulimima alkaloids, such as himbadine, isolated from Galbulimima belgraveana and G. baccatta, trees endemic to the rainforests of Northern Australia and Papua New Guinea, as well as analogs thereof, such as GB13, GB16, GB22, and himgaline, and further including intermediates useful in the synthesis of these and related compounds.

专利号:EP-2757104-A1
优先权日:2008-10-10
标 题:Compounds used in the synthesis of oxazolidinones

专利号:EP-2757104-B1
优先权日:2008-10-10
标题 :Compounds used in the synthesis of oxazolidinones

专利号:ES-2744907-T3
优先权日:2008-10-10
标 题:Compounds used in the synthesis of oxazolidinones

专利号:CN-118184668-A
优先权日:2024-04-09
标 题 :Synthesis of a Class of Indole Spiro Compounds

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.