CAS: 70-55-3; 4-Methylbenzenesulfonamide

上下游产品

pyridine 4-methylbenzenesulfinyl chloride syn-benzaldehyde oxime p-toluene sulfinic acidN-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide N-tosyldiethanolamine N-methyl-p-toluenesulfonylamide 1-[1,4-dioxo-3-(toluene-4-sulfonylamino)-1,4-dihydro-[2]naphthyl]-pyridinium betaine

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:WO-2024183094-A1
优先权日:2023-03-07
标 题 :Use of ligand catalyst in synthesis of indole alkaloids
发明人：YAN PUCHA; Cheng Houan; ZHOU BO; HUA YUNYU; SUN ZEBIN; FU XINGFENG; LI YUANQIANG
权利人:ZHEJIANG JIUZHOU PHARM CO LTD
摘要:The present invention provides use of a ligand catalyst in the synthesis of indole alkaloids. The ligand catalyst is formula (1). A method for the catalytic synthesis of the indole alkaloids comprises the following steps: sequentially adding reactants, a metal catalyst, a ligand catalyst, an oxidizing agent, and an additive into a reaction container, adding an organic solvent, carrying out the reaction, and carrying out separation and purification to obtain an indole derivative. The chemical reaction formula of the indole derivative is as follows: formula (2), wherein R1 is selected from one of hydrogen, alkyl, alkoxy, and aryl, R2 is selected from one of trifluoromethanesulfonyl, p-toluenesulfonyl, hydrogen, and alkyl, R3 is selected from one of alkyl, alkoxy, aryl, and heteroaryl, and R4 is selected from one of hydrogen, alkyl, alkoxy, aryl, and heteroaryl. The present invention solves the problem of low yield due to C(sp3)–H bonds being difficult to activate, and generates C-H bonds activated by means of the ligand, thereby reducing by-products.

专利号:US-11220513-B2
优先权日:2015-04-30
标题:Chromium-mediated coupling and application to the synthesis of halichondrins
发明人：KISHI YOSHITO; YAN WUMING; LI JINGWEI; LI ZHANJIE; YAHATA KENZO
权利人:HARVARD COLLEGE
摘要:The present invention provides unified synthesis of the C1-C19 building blocks of halichondrins and analogs thereof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hybridized carbon. The provided efficient selective coupling reactions can allow easy access to the C1-C19 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates.