CAS: 866081-62-1; 2,3-Bis((R)-Tert-Butyl(Methyl)Phosphino)Quinoxaline
该化合物是磷化合物,其特征是五氧碱混合物和多种叔丁基混合物.该化合物具有磷酸化合物,因其作为悬浮体和协调化学的功能而闻名,往往与过渡金属形成复杂体.该亚丁基化合物组对分子的不动成份起到了作用,影响其再活动性和溶解性.五氧基结构由于其芳香性质和参加欧元堆叠互动的能力,为有机合成和材料科学的各种应用提供了潜力.此外,该化合物的存在还可能具有独特的电子特性,使其对催化和开发新材料感兴趣.
- 英文名称2,3-Bis((R)-Tert-Butyl(Methyl)Phosphino)Quinoxaline
- 中文名称(R,R)-(–)-2,3-双(叔丁基甲基膦基)喹喔啉
- IUPAC名称2,3-bis((R)-tert-butyl(methyl)phosphaneyl)quinoxaline
- 其它别名2,3-Bis(T-Butylmethylphosphino)-Quinoxaline; (R,R)-(-)-2,3-Bis(Tert-Butylmethylphosphino)Quinoxaline; 2,3-Bis[(1,1-Dimethylethyl)Methylphosphino]Quinoxaline; (R)-Tert-Butyl-[3-[tert-Butyl(Methyl)Phosphanyl]Quinoxalin-2-Yl]-M
- CAS编号866081-62-1
- MFCD编号:MFCD10565649
- EINECS号:634-522-0
- 分子式:C18H28N2P2
- 分子量:334.38
- 产品CID: 1868868
- 产品分类Chemistry → Heterocyclic Building Blocks → Quinoxalines | Phosphoruses
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS06;
注释: Skull and crossbones - 危险类别急性毒性 类别3(经口)
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2
水生慢性毒性 类别4 - 警示词Danger(危险)
- 危险描述H301 |吞咽会中毒.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H413 |可能对水生生物造成长期有害影响. - 防范说明P273-P301+P310+P330-P302+P352-P305+P351+P338
- UN编号UN2811 6.1/PG 3
- 危险品标志Xn
- 安全声明26
- 危险类别码22-36/37/38
- WGK Germany3
欧盟法规
C&L通报上下游产品
2,3-dichloroquinoxaline (R)-tert-butyl(hydroxymethyl)methylphosphine borane (+/-)-tert-butylmethylphosphine borane bis-[2,3-bis(tert-butylmethylphosphino)quinoxaline]gold(I) chloride合成工艺路线路线简述
- 2213-63-0 + 263768-77-0 = 866081-62-1
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C1.2 -1.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine
标题:Efficient Preparation Of (S)- And (R)-Tert-Butylmethylphosphine-Borane: A Novel Entry To Important P-Stereogenic Ligands
作者:Salomo,Ernest; Et Al
参考文献:Synthesis 日期:2016 卷标:48(16) 页码:2659-2663]
= 866081-62-1
反应条件:1.1 Reagents: 4-Methylmorpholine,Methanesulfonic Anhydride Solvents: Dichloromethane; -20 °C; 1 H,-20 °C1.2 Reagents: Tetrabutylammonium Borohydride Solvents: Dichloromethane; -20 °C; 2 H,-20 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; -20 °C2.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C2.2 -2.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine
标题:Efficient Preparation Of (S)- And (R)-Tert-Butylmethylphosphine-Borane: A Novel Entry To Important P-Stereogenic Ligands
作者:Salomo,Ernest; Et Al
参考文献:Synthesis 日期:2016 卷标:48(16) 页码:2659-2663]
= 866081-62-1
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Acetone,Water; Rt; 1 H,Rt1.2 Reagents: Potassium Hydroxide,Potassium Persulfate Catalysts: Ruthenium Trichloride Solvents: Acetone,Water; 0 °C; 2 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Neutralized2.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 15 Min,-78 °C2.2 Solvents: Tetrahydrofuran; -78 °C; 2 H,Rt2.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine; 2 H,Rt2.4 Reagents: Hydrochloric Acid Solvents: Water
标题:(R,R)-2,3-Bis(Tert-Butylmethylphosphino)Quinoxaline (Quinoxp) As A Ligand For Rhodium-Catalyzed Asymmetric Hydrogenation Of Prochiral Amino Acid And Amine Derivatives
作者:Imamoto,Tsuneo; Et Al
参考文献:Catalysts For Fine Chemical Synthesis 日期:2007 卷标:5 页码:65-73]
203000-43-5 = 866081-62-1
反应条件:1.1 Reagents: Sparteine,Sec-Butyllithium Solvents: Diethyl Ether,Cyclohexane; 15 Min,-78 °C1.2 Solvents: Diethyl Ether; -78 °C; 5 H,-78 °C1.3 Reagents: Triethyl Phosphite,Oxygen; 1 H,-78 °C1.4 Reagents: Hydrochloric Acid Solvents: Water; Cooled2.1 Solvents: Pyridine; 0 °C; 0 °C -> Rt; 1 H,Rt2.2 Reagents: Hydrochloric Acid Solvents: Water3.1 Reagents: Potassium Hydroxide Solvents: Acetone,Water; Rt; 1 H,Rt3.2 Reagents: Potassium Hydroxide,Potassium Persulfate Catalysts: Ruthenium Trichloride Solvents: Acetone,Water; 0 °C; 2 H,Rt3.3 Reagents: Hydrochloric Acid Solvents: Water; Neutralized4.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 15 Min,-78 °C4.2 Solvents: Tetrahydrofuran; -78 °C; 2 H,Rt4.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine; 2 H,Rt4.4 Reagents: Hydrochloric Acid Solvents: Water
标题:(R,R)-2,3-Bis(Tert-Butylmethylphosphino)Quinoxaline (Quinoxp) As A Ligand For Rhodium-Catalyzed Asymmetric Hydrogenation Of Prochiral Amino Acid And Amine Derivatives
作者:Imamoto,Tsuneo; Et Al
参考文献:Catalysts For Fine Chemical Synthesis 日期:2007 卷标:5 页码:65-73]
25979-07-1 + 126456-43-7 = 866081-62-1
反应条件:1.1 Reagents: Diethylamine1.2 -1.3 Reagents: (Dimethyl Sulfide)Trihydroboron2.1 Solvents: Toluene; 100 °C3.1 Reagents: Sulfuric Acid Solvents: Methanol,Water4.1 Reagents: 4-Methylmorpholine,Methanesulfonic Anhydride Solvents: Dichloromethane; -20 °C; 1 H,-20 °C4.2 Reagents: Tetrabutylammonium Borohydride Solvents: Dichloromethane; -20 °C; 2 H,-20 °C4.3 Reagents: Hydrochloric Acid Solvents: Water; -20 °C5.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C5.2 -5.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine
标题:Efficient Preparation Of (S)- And (R)-Tert-Butylmethylphosphine-Borane: A Novel Entry To Important P-Stereogenic Ligands
作者:Salomo,Ernest; Et Al
参考文献:Synthesis 日期:2016 卷标:48(16) 页码:2659-2663]
2213-63-0 + 263563-97-9 = 866081-62-1
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 15 Min,-78 °C1.2 Solvents: Tetrahydrofuran; 1 H,-78 °C -> Rt; 3 H,Rt1.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine; 2 H,Rt1.4 Reagents: Hydrochloric Acid Solvents: Water; Rt
标题:An Air-Stable P-Chiral Phosphine Ligand For Highly Enantioselective Transition-Metal-Catalyzed Reactions
作者:Imamoto,Tsuneo; Et Al
参考文献:Journal Of The American Chemical Society 日期:2005 卷标:127(34) 页码:11934-11935]
2213-63-0 + 360787-11-7 = 866081-62-1
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -78 °C; 15 Min,-78 °C1.2 Solvents: Tetrahydrofuran; 1 H,-78 °C -> Rt; 3 H,Rt1.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine; 2 H,Rt1.4 Reagents: Hydrochloric Acid Solvents: Water; Rt
标题:2,3-Bis[(R)-(1,1-Dimethylethyl)Methylphosphino]-Quinoxaline
作者:Lebel,Helene
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2011 卷标:1 页码:1-3]
= 866081-62-1
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Methanol,Water2.1 Reagents: 4-Methylmorpholine,Methanesulfonic Anhydride Solvents: Dichloromethane; -20 °C; 1 H,-20 °C2.2 Reagents: Tetrabutylammonium Borohydride Solvents: Dichloromethane; -20 °C; 2 H,-20 °C2.3 Reagents: Hydrochloric Acid Solvents: Water; -20 °C3.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C3.2 -3.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine
标题:Efficient Preparation Of (S)- And (R)-Tert-Butylmethylphosphine-Borane: A Novel Entry To Important P-Stereogenic Ligands
作者:Salomo,Ernest; Et Al
参考文献:Synthesis 日期:2016 卷标:48(16) 页码:2659-2663]
98-88-4 + 281667-49-0 = 866081-62-1
反应条件:1.1 Solvents: Pyridine; 0 °C; 0 °C -> Rt; 1 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water2.1 Reagents: Potassium Hydroxide Solvents: Acetone,Water; Rt; 1 H,Rt2.2 Reagents: Potassium Hydroxide,Potassium Persulfate Catalysts: Ruthenium Trichloride Solvents: Acetone,Water; 0 °C; 2 H,Rt2.3 Reagents: Hydrochloric Acid Solvents: Water; Neutralized3.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 15 Min,-78 °C3.2 Solvents: Tetrahydrofuran; -78 °C; 2 H,Rt3.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine; 2 H,Rt3.4 Reagents: Hydrochloric Acid Solvents: Water
标题:(R,R)-2,3-Bis(Tert-Butylmethylphosphino)Quinoxaline (Quinoxp) As A Ligand For Rhodium-Catalyzed Asymmetric Hydrogenation Of Prochiral Amino Acid And Amine Derivatives
作者:Imamoto,Tsuneo; Et Al
参考文献:Catalysts For Fine Chemical Synthesis 日期:2007 卷标:5 页码:65-73]
= 866081-62-1
反应条件:1.1 Solvents: Toluene; 100 °C2.1 Reagents: Sulfuric Acid Solvents: Methanol,Water3.1 Reagents: 4-Methylmorpholine,Methanesulfonic Anhydride Solvents: Dichloromethane; -20 °C; 1 H,-20 °C3.2 Reagents: Tetrabutylammonium Borohydride Solvents: Dichloromethane; -20 °C; 2 H,-20 °C3.3 Reagents: Hydrochloric Acid Solvents: Water; -20 °C4.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C4.2 -4.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine
标题:Efficient Preparation Of (S)- And (R)-Tert-Butylmethylphosphine-Borane: A Novel Entry To Important P-Stereogenic Ligands
作者:Salomo,Ernest; Et Al
参考文献:Synthesis 日期:2016 卷标:48(16) 页码:2659-2663
海关参考信息
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专利信息
专利号:US-12162829-B2
优先权日:2021-12-16
标 题:Gas phase process for acrylate production from ethylene and carbon dioxide
发明人：Iacono Pasquale; SUTHERLAND JAMIE N; ASH CARLTON E; RAMANATHAN ANAND
权利人:CHEVRON PHILLIPS CHEMICAL CO LP
摘要:Catalysts and catalytic processes for the synthesis of acrylic acid and other α,β-unsaturated carboxylic acids and their salts, which are carried out in a diluent or in the absence of a diluent. In an aspect, ethylene and CO2 can be contacted with a Group 8-11 transition metal precursor compound or a Group 8-11 transition metal metalalactone compound in the presence of a metal-treated chemically-modified solid oxide (MT-CMSO) or a metal-treated solid oxide (MT-SO), to form a metal acrylate. As the catalytic activity wanes in either the presence or absence of a diluent, pressure cycling—that is, pressurizing the reaction system with CO2 and an olefin such as ethylene for a time period, releasing the pressure, then re-pressurizing with CO2 and ethylene—can rejuvenate the catalyst and restore its declining catalytic activity.
专利号:US-10370323-B2
优先权日:2014-09-26
标题:Method for preparing chiral gamma-secondary amino alcohol
发明人：ZHANG WANBIN; ZHANG ZHENFENG; HU QIUPENG
权利人:UNIV SHANGHAI JIAOTONG; NIPPON CHEMICAL IND
摘要:A method for preparing chiral γ-secondary amino alcohol includes: adding into a solvent an acid addition salt of β-secondary amino ketone represented by general formula (1), an alkali, a metal salt additive and a diphosphine-rhodium complex, so as to carry out a reaction in a hydrogen atmosphere and obtain a chiral γ-secondary amino alcohol compound represented by general formula (2). In general formula (2), Ar represents an aryl group with or without substituent group(s), R represents an alkyl group or an aralkyl group, and HY represents an acid. The synthesis scheme has a simple process, the metal salt additive remarkably improves the effect of a rhodium-catalyzed asymmetric hydrogenation technology, and accordingly, the reaction yield and the optical purity of a product are improved, the production process is simplified, production costs are reduced, and the synthesis scheme is highly suitable for mass industrial production.
专利号:CN-113980017-A
优先权日:2021-11-25
标题 :Synthesis method of C-13 methyl substituted tetrahydro 13 methyl berberine derivative
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合成参考文献
摘要:Jackowski, O.; Perez-Luna, A., Science of Synthesis Knowledge Updates, (2022) 3, 61.
摘要:Tius, M. A., Science of Synthesis Knowledge Updates, (2022) 1, 462.
摘要:Brown, J. M.; Nguyen, B. N., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 317.
摘要:Goetzke#, F. W.; Modicom#, F.; Fletcher, S. P., Science of Synthesis, (2022) , 364.
摘要:Liao, L.; Zhang, Y.; Yu, J.-S., Science of Synthesis: Knowledge Updates, (2024) 1, 226.
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