CAS: 98-59-9; P-Toluenesulfonyl Chloride

上下游产品

CAS号106-45-6 4-甲基苯硫酚 | CAS号103-19-5 对甲苯二硫醚 | CAS号37091-73-9 2-氯-1,3-二甲基氯化咪唑啉 | CAS号657-84-1 对甲苯磺酸钠 | CAS号108-88-3 甲苯 | CAS号104-15-4 对甲苯磺酸 | CAS号106-49-0 对甲苯胺 | CAS号100-83-4 间羟基苯甲醛 | CAS号536-57-2 对甲苯亚磺酸 | CAS号873-55-2 苯亚磺酸钠 | CAS号10473-10-6 2-ethenyl-9H-fl... | CAS号108832-06-0 (2-oxo-3-phenyl... | CAS号1028-19-9 1-[(4-Methylphe... | CAS号110216-96-1 (3-ethyl-1-meth... | CAS号109628-27-5 N-(6-甲氧-8-喹啉基)-... | CAS号112116-24-2 3,3-(1,6-己烷二氧基)双苯甲醛 | CAS号111711-61-6 5-ethoxy-1-(4-m... | CAS号106745-67-9 4-methyl-N-(2-p... | CAS号1028-12-2 4-methylbenzene... | CAS号106948-07-6 4-methylbenzene...

4-甲苯硫酚置于三氯异氰尿酸,水体系中,用 乙腈 作为反应溶剂,化学反应 0.33H,以98%的收率获得产物对甲苯磺酰氯
参考文献:三氯异氰尿酸 (Tcca) 和 N-氯代琥珀酰亚胺 (Ncs) 作为硫醇和二硫化物直接氧化转化为磺酰氯的有效试剂
标题:三氯异氰尿酸 (Tcca) 和 N-氯代琥珀酰亚胺 (Ncs) 作为硫醇和二硫化物直接氧化转化为磺酰氯的有效试剂
摘要:摘要 三氯异氰脲酸 (Tcca) 和 N-氯琥珀酰亚胺 (Ncs) 被发现是一种温和而有效的试剂,可通过氧化氯化将硫化合物直接氧化转化为相应的芳烃磺酰氯,产率从非常好到优异.整个过程简单实用,为获得多种芳基或杂芳基磺酰氯提供了方便.温和的反应条件和广泛的底物范围使该方法具有吸引力并与现有的芳基或杂芳基磺酰氯的合成互补.图形概要
DOI:10.1080/10426507.2011.621910

专利信息

专利号:WO-2021014395-A1
优先权日:2019-07-24
标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.

专利号:US-12441721-B2
优先权日:2020-07-21
标 题 :Synthesis of heterocyclic compounds from carboxamide and carboxamide derivatives with haloalkanols
发明人：KARPOORMATH RAJSHEKHAR; SAYYAD NISAR
权利人:UNIV OF KWAZULU NATAL
摘要:The invention provides for methods for the synthesis of various compounds through reaction of carboxamide, or carboxamide derivatives, with various substituted or unsubstituted haloalkanols in a one-step, single vessel, reaction mechanism. Preferably, but not exclusively, the reaction proceeds in the absence of any solvents, catalyst, base, or any further reagents.

专利号:US-11945838-B2
优先权日:2018-12-20
标 题:Method for synthesis of protein amphiphiles
发明人：BRITTO Sandanaraj Selvaraj; REDDY Mullapudi Mohan
权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES
摘要:The present invention discloses a novel cost effective method for synthesis of protein/peptide amphiphiles irrespective of functional and structural classification of proteins useful in designing a vaccine candidate from antigenic protein. The protein modification of the present invention is universal and hence any protein/peptide can be converted into amphiphilic proteins/peptides.

专利号:US-5849936-A
优先权日:1995-03-15
标题:Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
发明人：HOYE THOMAS R; TAN LUSHI
权利人:UNIVERISTY OF MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-7420052-B2
优先权日:2001-08-24
标 题:Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines
发明人：FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI; YOKOSHIMA SATOSHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An intermediate for vinblastine synthesis represented by general formula A. n ngeneral formula A.n n(in the formula, R 1 , R 2 , R 3 and R 4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R 5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R 6 is an alkyl group of carbon number 4 or less, R 7 is a substituted or non-substituted aryl group, R 8 is a substituted or non-substituted aryl group or lower alkyl group and R 9 is an acyl group or trialkylsilyl group.) A method for synthesis of the compound of general formula A utilizing radical ring forming reaction of thioanilides and using the compound of general formula B as the starting material, synthesizing thioanilide of general formula C by the reaction with compound 1 and the formation of a 11-membered ring by intramolecular alkylation of 2-nitrobenzenesulfonamide by which the reactions can proceed under mild conditions and high yield can be accomplished.