CAS: 132388-69-3; Boc-Gln(Trt)-Oh

相似化合物

210750-95-1 102747-84-2 112898-00-7

上下游产品

CAS号76-84-6 三苯基甲醇 | CAS号2650-64-8 N-苄氧羰基-L-谷氨酰胺 | CAS号132388-60-4 N-Cbz-N’-三苯甲基-L-谷氨酰胺 | CAS号56-85-9 L-谷氨酰胺 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号102747-84-2 N'-三苯甲基-L-谷氨酰胺

三苯基甲醇置于palladium On Activated Charcoal 盐酸,硫酸,氢气,乙酸酐体系中,用 甲醇,水,溶剂黄146 用作溶剂,化学反应 2.0H,反应生成N-Boc-N'-三苯甲基-L-谷氨酰胺
参考文献:三苯甲基残基保护羧酰胺功能.在肽合成中的应用
标题:三苯甲基残基保护羧酰胺功能.在肽合成中的应用
摘要:羧酰胺官能团可以通过在冰醋酸中与三苯甲醇和乙酸酐进行酸催化反应来三苯甲基化.天冬酰胺和谷氨酰胺的ω-三苯甲基可被tfa裂解,但对水溶液中的强无机酸以及亲核试剂和碱稳定.在肽合成中,它非常适合与叔丁基类型的侧链保护结合使用.
Doi:10.1016/s0040-4039(00)74872-6

专利信息

专利号:US-2018265547-A1
优先权日:2014-07-18
标 题 :Z-selective olefin metathesis of peptides
发明人：MANGOLD SHANE L; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:ES-2616871-T3
优先权日:2009-06-01
标 题 :Synthesis of relaxin peptide