CAS: 13598-36-2; Phosphonic Acid

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CAS号696-62-8 4-碘苯甲醚 | CAS号6303-21-5 次磷酸 | CAS号13697-89-7 1,3-二氟-2-碘苯 | CAS号7719-12-2 三氯化磷 | CAS号12185-10-3 黄磷 | CAS号7732-18-5 水 | CAS号94-36-0 过氧化苯甲酰 | CAS号7782-68-5 碘酸 | CAS号66314-64-5 1,2,3,4,5,6-hex... | CAS号1070-42-4 bis(2-chloroeth... | CAS号7803-51-2 磷化氢 | CAS号7664-38-2 磷酸 | CAS号1333-74-0 氢 | CAS号7783-06-4 硫化氢 | CAS号14939-39-0 dibromo(oxo)pho... | CAS号25757-29-3 bromo-hydroxy-o... | CAS号14939-29-8 fluoro-hydroxy-... | CAS号16672-87-0 乙烯利 | CAS号20135-59-5 1-[butoxy(2-chl...

Phosphorus置于air,水体系中,化学反应生成亚磷酸
参考文献:Berzelius,J. J.,Lehrbuch Der Chemie,Ed.5. Vol.1. Dresden-Leipzig 1843,P.558.
标题:Berzelius,J. J.,Lehrbuch Der Chemie,Ed.5. Vol.1. Dresden-Leipzig 1843,P.558.

专利信息

专利号:US-12012427-B2
优先权日:2019-10-31
标 题 :Synthesis of Fmoc-protected morpholino monomers and their use in the synthesis of morpholino oligomer
发明人：SINHA SURAJIT; KUNDU JAYANTA; GHOSH UJJWAL
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:Present invention relates to stable Fmoc protected Morpholino monomers and corresponding oligonucleotides (PMO) and efficient synthesis of the same involving chlorophosphoramidate and H-Phosphonate chemistry. Successful syntheses of the oligonucleotide with higher yield and lesser time have been accomplished employing solid phase synthesis and easy deprotection of Fmoc group with Piperidine.

专利号:US-11866398-B2
优先权日:2018-05-15
标 题:Total synthesis of prostaglandin J natural products by stereoretentive metathesis
发明人：LI JIAMING; CHEN XU; AHMED TONIA S; STOLTZ BRIAN M; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

专利号:EP-1634887-A3
优先权日:2004-07-23
标题 :Process for synthesis of complex 2-deoxy-2-iodo pyranosides of high purity, particularly suitable for manufacturing pharmaceutically pure annamycin
发明人：SZEJA WIESLAW; FOKT IZABELA; GRYNKIEWICZ GRZEGORZ
权利人:ZAKLAD BADAWCZO PROD
摘要:The method according to the invention comprises using as glycosyl donors high purity 2-deoxy-2-iodo derivatives of sugars of a defined configuration of C-2 carbon with O-alkyl, S-alkyl, O-aryl, S-aryl, O-heteroaryl, S-heteroaryl, O-acyl, O-silyl, O-N-imido, O-P-(phosphino, phosphono, thiophosphono, selenophosphono) groups at the anomeric position, and subjecting them to a condensation reaction with a compound containing a hydroxyl group or a protected hydroxyl group in the presence of electrophilic reagents, followed by deprotection and isolation of a pharmaceutically pure product. The objective of the present invention is to provide a method for preparing complex glycosides by coupling cyclic multifunctional compounds containing hydroxyl functional groups (glycosyl acceptors, including aglycones of natural origin which are known as constituents of active pharmaceutical ingredients) with diastereoisomerically pure 2-deoxy-2-halopyranosyl derivatives containing anomeric substituent capable of exchange under glycosidating conditions, for example by virtue of activation with electrophilic agents. This method substantially simplifies the synthesis of Annamycin. n The present invention relies on a regio- and stereoselective reaction of cohalogenating 1,2-unsaturated sugars in the presence of hydroxyl group containing compounds, such as: water, alcohols, phenols, carboxylic acids, silanols, phosphinic acids, phosphoric acids, thiophosphoric acids, selenophosphoric acids, followed by separation of the product with proper C-2 carbon configuration required for the synthesis. As the separation of stereoisomers is carried out at the stage of obtaining a relatively inexpensive intermediate in the form of glycosyl donor, the method of the invention substantially reduces the cost of Annamycin manufacture. Other advantages of the synthesis process of the invention consist in the reduction of the number of stages of the antibiotic manufacture process and in yield increase of the final product.

专利号:US-7652164-B2
优先权日:2005-09-13
标题:Process for the direct synthesis of trialkoxysilane
发明人：LEWIS KENRICK M; MEREIGH ABELLARD T; O'YOUNG CHI-LIN; CAMERON RUDOLPH A
权利人:MOMENTIVE PERFORMANCE MAT INC
摘要:The Direct Synthesis of trialkoxysilane is carried out by conducting the Direct Synthesis reaction of silicon and alcohol, optionally in solvent, in the presence of a catalytically effective amount of Direct Synthesis catalyst and an effective catalyst-promoting amount of Direct Synthesis catalyst promoter, said promoter being an organic or inorganic compound possessing at least one phosphorus-oxygen bond.

专利号:US-7241399-B2
优先权日:2000-09-08
标题 :Synthesis of nanoparticles
发明人：HAUBOLD STEPHAN; HAASE MARKUS; RIWOTZKI KARSTEN; WELLER HORST; MEYSSAMY HEIKE; IBARRA FERNANDO
权利人:CT ANGEWANDTE NANOTECH CAN
摘要:Methods for the preparation of inorganic nanoparticles capable of fluorescence, wherein the nanoparticles consist of a host material that comprises at least one dopant. The synthesis of the invention in organic solvents allows to gain a considerably higher yield compared to the prior art synthesis in water. All kinds of objects can advantageously be marked and reliably authenticated by using an automated method on the basis of a characteristic emission. Further, the size distribution of the prepared nanoparticles is nartower which renders a subsequent size-selected separation process superfluous.

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.