CAS: 154057-58-6; ((2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)Methyl)Triphenylphosphonium Bromide

相似化合物

154057-58-6 154057-56-4 121660-11-5

上下游产品

3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline triphenylphosphine 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline methyl 4-(4'-fluorophenyl)-2-cyclopropylquinoline-3-carboxylate (R)-1-phenylethanamine (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate (4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

2-环丙基-4-(4-氟苯基)-3-喹啉甲醇置于三溴化磷体系中,用 二氯甲烷,甲苯 用作溶剂,化学反应 8.0H,反应生成匹伐他汀钙中间体3
参考文献:Synthesis Of Artificial Hmg-Coa Reductase Inhibitors Based On The Olefination Strategy
标题:Synthesis Of Artificial Hmg-Coa Reductase Inhibitors Based On The Olefination Strategy
摘要:研究了合成光学活性6-氧代-3,5-异丙基二氧六酸酯(4)的方法,这些化合物可作为各种人工类3-羟基-3-甲基戊二酸酰辅酶a(hmg-Coa)还原酶抑制剂的关键前体.通过对来自塔贝酒精或l-酒石酸盐的β,δ-二酮酯进行不对称还原,制备了对映异构体(+)-4,随后经过一系列化学转化,最终得到所需的对映异构体(−)-4,并通过相同的不对称还原方法从d-酒石酸盐出发制得.关键中间体(−)-4最终转化为一种高效的hmg-Coa还原酶抑制剂nk-104.
Doi:10.1246/bcsj.68.364