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异丁酰胺置于[(N-Tosylimino)Iodo]Benzene体系中,用 二氯甲烷 用作溶剂,化学反应 1.5H,反应生成异氰酸异丙酯
参考文献:(tosylimino)苯基λ 3-Iodane作为试剂用于通过芳香族和脂肪族甲酰胺的霍夫曼重排甲基氨基甲酸酯的合成
标题:(tosylimino)苯基λ 3-Iodane作为试剂用于通过芳香族和脂肪族甲酰胺的霍夫曼重排甲基氨基甲酸酯的合成
摘要:一种新的,温和的程序使用(tosylimino)苯基-λ芳香族和脂肪族羧酰胺的霍夫曼重排3-Iodane,Phints,作为试剂被报告.由于反应条件温和,该方法对于取代的苯甲酰胺的霍夫曼重排特别有用,该苯甲酰胺通常会提供与其他高价碘氧化剂的复杂反应混合物.羧酰胺与phints反应的温和反应条件和高选择性可以分离最初形成的不稳定异氰酸酯,或通过用醇处理将其随后转化为稳定的氨基甲酸酯.
Doi:10.1021/jo300007C

专利信息

专利号:US-2004138469-A1
优先权日:2002-12-23
标 题 :Process for the synthesis of torsemide, in particular of pure and stable form II
发明人：LUSSANA MASSIMILIANO; RAINONI MAURO; GAMBUZZA FILIPPO
权利人:COSMA S P A
摘要:The present invention relates to a new process for the synthesis of torsemide, in particular of pure and stable form II, which comprises direct synthesis of torsemide from 4-(3-methylphenylamino)-3-pyridine-sulphonamide. The new process envisages fewer steps than the processes described in the prior art, with improved yields and good quality from the chemical and preferably polymorphous points of view.

专利号:US-12338202-B2
优先权日:2021-09-10
标 题 :One pot synthesis of urea (meth)acrylates
发明人：BESTGEN SEBASTIAN; BEYER SILVIA
权利人:EVONIK OPERATIONS GMBH
摘要:A one-pot synthesis of polymerizable and acyclic urea (meth)acrylates, preferably mono(meth)acrylates, can be performed via in-situ synthesis of urea alcohols or amines followed by direct reaction with a (meth)acrylate reactive diluent. The urea alcohol/amine is obtained from isocyanates and alcohols, amines, or hydroxyamines. Subsequently, the reaction with the (meth)acrylate reactive diluent takes place and the urea (meth)acrylate is directly obtained either in solution with the reactive diluent, or as a pure material after removal of the reactive diluent.

专利号:US-5696290-A
优先权日:1994-09-12
标 题:Synthesis of penta-substituted guanidines
发明人：RUETTIMANN KENNETH W; MCGHEE WILLIAM D; SOLODAR A JOHN
权利人:MONSANTO CO
摘要:The present invention is the novel synthesis of sterically hindered penta-substituted guanidines by a process in which (1a) an isocyanate is reacted first with a di-substituted amine or (1b) a urea is reacted with two moles of a mono-substituted amine to form a tri-substituted urea followed by (2) treatment of the tri-substituted urea with an activating agent before reacting with a second di-substituted amine in the presence of a base.

专利号:US-11655255-B2
优先权日:2022-10-17
标题 :Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein
发明人：ZHANG WANBIN; WANG MO; ZHANG LU; HUO XIAOHONG; ZHANG ZHENFENG; YUAN QIANJIA; CHEN JIANZHONG
权利人:SPH NO 1 BIOCHEMICAL & PHARMACEUTICAL CO LTD; UNIV SHANGHAI JIAOTONG
摘要:A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir. Specifically, a nucleoside and phosphoryl chloride are subjected to asymmetric reaction under the catalysis of a chiral bicyclic imidazole catalyst in the presence of a base to produce the P-stereogenic nucleoside derivative of formula (3)

专利号:US-6919382-B2
优先权日:2000-08-31
标 题 :Preparation and uses of conjugated solid supports for boronic acids
发明人：HALL DENNIS G
权利人:UNIV ALBERTA
摘要:The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and dihydroxyalkylaminobenzyl groups, and methods for making and using them. The supports are particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid phase synthesis, such as those used in combinatorial chemistries. The compositions and methods of the invention are also useful as scavenger solid supports, e.g., in solution-phase parallel synthesis of small molecule libraries, and for use in resin-to-resin transfer reactions via phase transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The methods of the invention provide convergent solid-phase synthesis of symmetrically or unsymmetrically functionalized compounds, such as biphenyl compounds. Also provided are synthesizer devices, e.g., semiautomated parallel synthesizers.

专利号:US-3781324-A
优先权日:1969-11-03
标 题:Certain 6-trifluoromethylcytosines and thiocytosines,their synthesis,and their use in the synthesis of uracils and thiouracils
发明人：LUTZ A
权利人:AMERICAN CYANAMID CO
摘要:3-AMINO-2-SUBSTITUTED - 4,4,4 - TRIFLUORO-2-BUTENENITRILES ARE REACTED WITH ISOCYANATES OR ISOTHIOCYANATES IN THE PRESENCE OF AN INERT SOLVENT AND FROM 0.75 TO ABOUT 1.0 MOLE EQUIVALENTS OF STRONG BASE PER MOLE OF BUTENENITRILE TO PRODUCE THE NOVEL UREIDO BUTENENITRILES OF THE FORMULA: CF3-C(-NH-C(=X)-NH-R)=C(-HALO)-CN WHEREIN R IS ALKYL, ALKENYL, PHENYL, BENZYL AND SUBSTITUTED DERIVATIVES THEREOF AND X IS SULFUR OR OXYGEN. THE UREIDO BUTENENITRILE ARE TREATED WITH ADDITIONAL BASE TO PRODUCE NOVEL CYCLIC CYTOSINES OF THE FORMULA: 6-CF3,5-HALO,4-(HN=),3-R,2-(X=)-1,2,3,4-TETRAHYDRO- PYRIMIDINE WHEREIN R AND X ARE AS DEFINED ABOVE. THE CYTOSINES CAN BE PRODUCED DIRECTLY BY TREATING 3-AMINO-2-SUBSTITUTED4,4,4-TRIFLUORO-2-BUTENENITRILE WITH AT LEAST 1.0 MOLE EQUIVALENT OF BASE. THE NOVEL COMPOUNDS ARE USEFUL INTERMEDIATES IN THE PREPARATION OF HERBICIDAL URACILS AND THIOURACILS.