CAS: 38235-77-7; (R)-N-Benzyl-1-Phenylethanamine

上下游产品

CAS号14428-98-9 Benzenemethanam... | CAS号3886-69-9 R(+)-alpha-甲基苄胺 | CAS号100-52-7 苯甲醛 | CAS号100-46-9 苄胺 | CAS号67-56-1 甲醇 | CAS号3129-98-4 N-Benzylidene-α... | CAS号134430-95-8 [R-(R*,S*)]-β-[...

N-Benzyl-N-(1-Phenylethylidene)Amine置于磷酸,C37H38N2O6Prus,氢气体系中,用 甲醇,二氯甲烷 用作溶剂,40.0 °C,5.07 Mpa 条件下,反应 10.0H,反应生成(R)-(+)-N-苄基-1-苯乙胺
参考文献:N-烷基和n-芳基酮亚胺的不对称氢化反应,使用手性阳离子钌(二胺)配合物作为催化剂:抗衡阴离子和溶剂作用以及底物范围
标题:N-烷基和n-芳基酮亚胺的不对称氢化反应,使用手性阳离子钌(二胺)配合物作为催化剂:抗衡阴离子和溶剂作用以及底物范围
摘要:的不对称氢化ñ-烷基和ñ通过催化芳基酮亚胺的手性阳离子η 6-Arene-(ñ-Monosulfonylated二胺)的ru(II)络合物进行了研究.观测到强烈的抗衡阴离子和溶剂对对映选择性的影响.钌催化剂轴承非配位barf-阴离子被认为是对无环和环外的氢化特别有效ñ-烷基酮亚胺在(boc)的存在下2O在二氯甲烷中或什至在无溶剂条件下提供的手性胺,其ee可达99%以上,并具有完全转化率.或者,在不存在(boc)2 O的情况下,具有手性磷酸根阴离子和相应磷酸作为添加剂的钌催化剂也有效用于n-烷基酮亚胺的氢化,对映选择性和完全转化率优异.对于ñ-芳基酮亚胺降低通过使用钌催化剂轴承barf观察对映体过量-阴离子.因此,该催化方案为光学活性胺提供了简便实用的途径,并已成功用于对映体纯的(+)-舍曲林的克级合成中.
Doi:10.1016/j.Tet.2012.03.019

专利信息

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-2009281176-A1
优先权日:2007-11-01
标题:Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.

专利号:WO-2009056993-A2
优先权日:2007-11-01
标题 :A process for the synthesis of ramelteon and its intermediates

专利号:US-2009069581-A1
优先权日:2007-05-31
标题:Process for the synthesis of ramelteon and its intermediates

专利号:WO-9852956-A1
优先权日:1997-05-16
标 题 :Pure enantiomer metallocene complexes and the production and use of the same
发明人：RINGWALD MARKUS
权利人:RINGWALD MARKUS
摘要:The invention relates to a method for producing pure enantiomer metallocene complexes from the archiral meso-form or the racemate of the corresponding metallocene complex or a mixture of the two in the presence of a pure enantiomer auxiliary reagent, using heat. The invention also relates to pure enantiomer metallocene complexes and their use in stereoselective synthesis.

专利号:WO-2024216017-A2
优先权日:2023-04-14
标题:Synthesis of ras inhibitors