CAS: 4421-08-3; 4-Hydroxy-3-Methoxybenzonitrile

上下游产品

4-cyano-2-methoxyphenyl acetate vanillin 4-(benzyloxy)-3-methoxybenzonitrile vanillin oxime 3,3'-dimethoxy-4,4'-butanediyldioxy-di-benzonitrile 3,3'-dimethoxy-4,4'-hexanediyldioxy-di-benzonitrile 4-hydroxy-3-methoxy-benzimidic acid ethyl ester; hydr°Chloride 3-methoxy-4-hydroxybenzoic acid

香草醛置于盐酸羟胺体系中,用 溶剂黄146 作为反应溶剂,化学反应 1.0H,以91%的收率获得产物4-羟基-3-甲氧基苯甲腈
参考文献:基于苯并吡喃亚结构的钾通道活化剂:C-8取代基的合成和活性.
标题:基于苯并吡喃亚结构的钾通道活化剂:C-8取代基的合成和活性.
摘要:已经完成了一系列带有甲氧基的2,2-二甲基-2H-1-苯并吡喃的合成,以作为钾通道活化剂进行测试.合成涉及从香兰素形成6-氰基-8-甲氧基-2,2-二甲基-2H-1-苯并吡喃,进行环氧化,然后用氮亲核试剂将环氧化物开环以反应生成新的苯并吡喃.生物测试显示活性显着下降,因此揭示了这类化合物的重要活性位点.
DOI:10.1016/s0968-0896(03)00058-0

专利信息

专利号:US-2011104055-A1
优先权日:2002-05-31
标题:Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies
发明人：SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
权利人:SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
摘要:Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.

专利号:US-7951827-B2
优先权日:2005-05-05
标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles
发明人：TIDWELL RICHARD R; BAKUNOVA SVETLANA M; BAKUNOV STANISLAV; PATRICK DONALD A
权利人:UNIV NORTH CAROLINA
摘要:Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.

专利号:US-5663449-A
优先权日:1989-05-19
标 题 :Intermediate compounds in the synthesis of heteroarylpiperidines, pyrrolidines and piperazines

专利号:US-5637710-A
优先权日:1989-05-19
标题:Intermediate compounds in the synthesis of heteroarylpiperidines and piperazines

专利号:US-2006264487-A1
优先权日:2005-05-05
标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles

专利号:AU-2006201739-A1
优先权日:2005-05-05
标题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles