专利号:US-11858953-B2 优先权日:2018-04-04 标 题:Compositions and methods for synthesis of phosphorylated molecules 发明人:CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT 权利人:UNIV CALIFORNIA 摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.
专利号:WO-2025217610-A1 优先权日:2024-04-12 标题:Systems and methods for enzymatic oligonucleotide synthesis 发明人:ENTWISTLE DAVID; GAUNTLETT DEREK; MILLER MICHAEL; REEVES RYAN; WATTS DAVID 权利人:CODEXIS INC 摘要:The present invention provides for methods and systems for template-free synthesis of an oligonucleotide, and methods of using the systems as disclosed herein for template-free synthesis of an oligonucleotide.
专利号:WO-2023086801-A1 优先权日:2021-11-09 标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use 发明人:HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN 权利人:VIGIL NEUROSCIENCE INC 摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.
专利号:US-2013172553-A1 优先权日:2009-11-25 标题 :Chiral synthesis of isoxazolines, isoxazoline compounds, and uses thereof 发明人:SIELECKI-DZURDZ THAIS; PRUITT JAMES 权利人:SIELECKI-DZURDZ THAIS; PRUITT JAMES; CPSI STOCKHOLDER TRUST 摘要:Processes for the chiral syntheses of isoxazolines and intermediates are described. Compounds prepared thereby, and methods of using the compounds are also described.
专利号:US-9493461-B2 优先权日:2013-02-07 标 题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C 发明人:DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; LAI ZHONG; NARGUND RAVI; MARCANTONIO KAREN; XIAO DONG; BROCKUNIER LINDA L; ZORN NICOLAS; DANG QUN; PENG XUANJIA; LI PENG 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-9243002-B2 优先权日:2013-02-07 标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C 发明人:DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; BROCKUNIER LINDA L; NARGUND RAVI; MARCANTONIO KAREN; ZORN NICOLAS; XIAO DONG; PENG XUANJIA; LI PENG; GUO TAO 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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合成参考文献
摘要:Semeniuk, T.; Hamel, J.-D., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2. 参考文献:10.1098/rsta.2004.1391 摘要:Wattis JAD. Nonlinear breathing modes due to a defect in a DNA chain. Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences. 2004 Jul 15;362(1820):1461–77. doi: 10.1098/rsta.2004.1391.