CAS: 4737-50-2; N-Pentylboronic Acid

该化合物是有机有机体化合物,其特征是附于一个聚苯乙烯链的黄酸功能组;该化合物一般是无色的,可粉黄黄色液体或固体,视其纯度和形态而定;众所周知,它能够与二醇形成可逆的共价联系,使其在各种应用中,特别是在有机合成和药用化学中具有价值;B-苯乙酸在极有机溶剂中是可溶的,可提高其在化学反应中的效用;其再活动主要归因于阳性原子,它可参与核分裂哲学攻击,并可促进交叉反应,如铃木-米亚鲁的结合,形成碳-碳联系;此外,由于二硝基基酸的存在会影响化合物的脂性与生物活动;在处理这一化合物时,应采取安全防范措施,因为丁基酸可能是刺激剂,如果不妥善处理,则可能对环境造成危害.

结构式图片

相似化合物

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CAS号121-43-7 硼酸三甲酯 | CAS号693-25-4 正戊基溴化镁 | CAS号68498-84-0 boric acid-carbon | CAS号1883-38-1 tripentylborane | CAS号18379-77-6 chlorodipentylborane | CAS号162213-34-5 n-pentyl-diisop... | CAS号73895-30-4 butyl pentyl pe... | CAS号73895-31-5 butoxy(tert-but... | CAS号33228-44-3 4-戊基苯胺 | CAS号71-41-0 正戊醇 | CAS号85017-60-3 1-碘-4-正戊烷基苯 | CAS号538-68-1 戊基苯 | CAS号121219-12-3 4-正戊基苯硼酸 | CAS号7325-09-9 2,4,6-tripentyl... | CAS号95857-32-2 1-nitro-4-penty...

合成工艺路线路线简述

    Tripentylborane置于水,三氯化硼体系中,化学反应生成 正戊基硼酸
    参考文献:Notes-Preparation And Reactions Of Some N-Amylated Boranes
    标题:Notes-Preparation And Reactions Of Some N-Amylated Boranes
    摘要:
    DOI:10.1021/jo01066A643

    海关参考信息

    专利信息


    专利号:US-7825244-B2
    优先权日:2005-06-10
    标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
    发明人:BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
    权利人:JANSSEN PHARMACEUTICA NV
    摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

    专利号:US-7205427-B2
    优先权日:2002-06-04
    标 题:Cross-coupling synthesis of alkyl (dialkylphenyl) indenes
    发明人:BARNES HAMLIN H
    权利人:BOULDER SCIENT CO
    摘要:A cross-coupling synthesis of 2-alkyl-4-(2,6-dialkylphenyl)indenes is described. A 2-alkylidene is treated with a dialkylboronic acid in the presence of a catalyst. A feature of the invention is the use of a cross-coupling catalyst comprising palladium dichloride (1,5-cyclooctadiene) as a cross-coupling catalyst.

    专利号:US-9862745-B2
    优先权日:2004-03-30
    标题 :Synthesis of boronic ester and acid compounds
    发明人:AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER
    权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC
    摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

    专利号:US-10973847-B2
    优先权日:2017-06-30
    标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
    发明人:JOHNSON JEREMIAH A; GOLDER MATTHEW R
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

    专利号:US-11434217-B2
    优先权日:2017-12-29
    标 题 :Method for synthesis of lobaric acid and analog thereof
    发明人:YIM JOUNG HAN; KIM IL-CHAN; HAN SE JONG; YOUN UI JOUNG; LEE HONG KUM; LEE JUN HYUCK; KIM TAI KYOUNG; YEO KWON JOO
    权利人:KOREA INST OCEAN SCI & TECH; KOREA INSTITUTE OF OCEAN SCIENCE AND TECH
    摘要:The present invention can synthesize lobaric acid and four analogues thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichen Stereocaulon alpinum and selectively inhibit PTP1B, by a simple, economic and efficient chemical synthesis method.

    专利号:US-2015336866-A1
    优先权日:2013-01-01
    标题:Synthesis of difluoromethyl ethers and sulfides
    发明人:HARTWIG JOHN; FIER PATRICK
    权利人:UNIV CALIFORNIA
    摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.
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    合成参考文献


    参考文献:10.1007/978-1-4939-6445-1_3
    摘要:Beesu M, Kokatla HP, David SA. Syntheses of Human TLR8-Specific Small-Molecule Agonists. Methods Mol Biol. 2017;1494():29–44. doi: 10.1007/978-1-4939-6445-1_3.
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