CAS: 55219-11-9; Benzo[b]Thiophene-2-Carbonitrile

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1,2-dithiophenyl-1,2-dicyan°Cyclopropane sodium cyanide Benzo[b]thiophene benzo[b]thiophene-2-carboxamideN-hydroxy-benzo[b]thiophene-2-carboxamidineN-hydroxy-benzo[b]thiophene-2-carboxamidine benzo[b]thiophen-2-ylmethanamine hydr°Chloride 3-ethoxy-4-methoxybenzylamine 2-Methylbenzothiophenebenzo[b]thiophene-2-carboxylic acid oxalyl dichloride tetraethyl (aminomethylene)bis(phosphonate)b]thiophene-2-carboxylic acid-(2,5-dichloro-anilide)benzo[b]thiophene-2-carboxylic acid-(2,5-dichloro-anilide) b]thiophene-2-carboxylic acid-(4-hydroxy-anilide)benzo[b]thiophene-2-carboxylic acid-(4-hydroxy-anilide) 3-benzo[b]thiophen-2-yl-3-oxopropionic acid ethyl ester b]thiophene-2-carboxylic acid-(2,4-dichloro-anilide)benzo[b]thiophene-2-carboxylic acid-(2,4-dichloro-anilide)benzothiophen-2-yllithium N-methyl-N-phenylformamide 1,1-dimethoxy-2-(2-formylthiophenoxy)ethane N,N-dimethyl-formamidethienyl)acrylonitrile(Z)-2-phenyl-3-(2-benzothienyl)acrylonitrile (2-benzothienyl)bis(4-dimethylaminophenyl)methane (E)-3-(benzo[b]thiophen-2-yl)-1-phenyl-2-propen-1-one b]thiophene-2-carbaldehyde-(2,4-dinitro-phenylhydrazone)benzo[b]thiophene-2-carbaldehyde-(2,4-dinitro-phenylhydrazone)thiophene-2-carboxylic acid chloridebenzothiophene-2-carboxylic acid chloride thien°Carbonyl)-N'-phenylthioureaN-(2-Benzothien°Carbonyl)-N'-phenylthiourea benzo[b]thiophene-2-carboxylic acid thiophene2-isothi°Cyanat°CarbonylbenzothiopheneN-[(benzo[b]thiophen-2-yl)methyl]amine 2-cyanobenzothiophene Benzo[b]thiophene benzo[b]thiophene-2-carboxylic acid2-acetyl benzo[b]thiophene 3-phenyl-2-thioxopropanoic acid α,α'-disulfanediyl-di-cinnamic acid 2-formylthiophenolmethyl benzo[b]thiophene-2-carboxylate benzothiophene-2-methanol 2,3-Dihydrobenzothiophene-2-carboxylic acid [4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-benzo[b]thiophen-2-yl-methanone2-(benzo[b]thiophen-3-yl)acetonitrile ethyl (2-chloroaceto)acetate sodium thiophenolate b]thiophen-3-ylmethyl-magnesium chloridebenzo[b]thiophen-3-ylmethyl-magnesium chloride-thienylacetamide3-benzo-thienylacetamide 4-((E)-2-Benzo[b]thiophen-3-yl-vinyl)-2,6-dimethyl-phenol 3-phenylbutyric acid thienylacetatemethyl 3-benzothienylacetatemethyllithium isothiazolo[5,4-b]benzo[b]thiophene (1)benzothieno(3,2-d)isoselenazole(1)benzothieno(3,2-d)isoselenazole sodium cyanidethiophene3-acetylbenzothiophene 2-phenylbenzo[b]thiophene-3-carbonitrile biphenyl PCB 11thiophene7-methoxybenzothiophene thiophene-2-carboxylic acid7-hydroxybenzothiophene-2-carboxylic acid 2-Trimethylsilyl-7-hydroxy-1-benzothiophene 6-bromo-5,6-dihydrobenzo[b]thiophen-7(4H)-onethiophen2,3-dihydro-7-hydroxybenzothiophen 2-p-Tolyl-2,3-dihydro-benzo[b]thiophen-7-ol 3-p-Tolyl-2,3-dihydro-benzo[b]thiophen-7-ol thiophen-7(6H)-one4,5-dihydro-2,4-di-p-tolylbenzothiophen-7(6H)-one4-phenethyl-1,2-dihydro-phenanthrene trans-4-Styrylphenanthrene trans-2-Styrylphenanthren (E,E)-1,3-distyrylbenzene

2-乙酰基苯并噻吩置于氧气,Copper(L) Cyanide体系中,用 二甲基亚砜 作为反应溶剂,以72%的收率获得产物2-氰基苯并噻吩
参考文献:以氰化物阴离子为氮源的好氧铜介导的芳族腈实用方法†
标题:以氰化物阴离子为氮源的好氧铜介导的芳族腈实用方法†
摘要:使用氰化物阴离子作为氮源,实现了cu介导的芳基甲基酮的氰化,从而以中等至非常好的收率提供了芳香腈.该反应耐受各种合成上重要的官能团.
DOI:10.1039/c6Ob01269H

专利信息

专利号:US-6664410-B1
优先权日:1999-07-15
标题 :Solid phase nitrile synthesis
发明人：KOBYLECKI RYSZARD; HONE NEAL DAVID; PAYNE LLOYD JAMES
权利人:MILLENNIUM PHARMACEUTICALS LTD
摘要:A nitrile compound is prepared by treating a solid supported amide to dehydrate it and cleave it from the support in one operation. The preparation involves acetylation of the amide compound in the presence of a base at a temperature of less than 100° C.