CAS: 585-76-2; 3-Bromobenzoic Acid

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CAS号591-17-3 3-溴甲苯 | CAS号6952-59-6 间溴苯甲腈 | CAS号591-18-4 1-溴-3-碘苯 | CAS号124-38-9 二氧化碳 | CAS号3132-99-8 间溴苯甲醛 | CAS号108-36-1 1,3-二溴苯 | CAS号115665-95-7 (E)-1-溴-3-(2-硝基乙烯基)苯 | CAS号65-85-0 苯甲酸 | CAS号3132-99-8 间溴苯甲醛 | CAS号39115-96-3 3-溴苄肼 | CAS号35306-74-2 3-溴-N-丙基苯甲酰胺 | CAS号90-90-4 4-溴二苯甲酮 | CAS号401-78-5 间溴三氟甲苯 | CAS号4885-18-1 (3-溴苯基)二甲胺 | CAS号20608-89-3 3-噻吩-3-苯甲酸 | CAS号2129-30-8 3-(二苯基膦基)苯甲酸 | CAS号18189-42-9 3-(ETHOXYCARBON... | CAS号1711-09-7 3-溴苯甲酰氯

间氨基苯甲酸置于n-溴代丁二酰亚胺(Nbs),Sodium Nitrite体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 6.0H,以72%的收率获得产物间溴苯甲酸
参考文献:通过亚硝酸钠和n-卤代琥珀酰亚胺将芳胺直接转化为卤代芳烃
标题:通过亚硝酸钠和n-卤代琥珀酰亚胺将芳胺直接转化为卤代芳烃
摘要:描述了一种在室温下在无金属和无酸条件下,通过与亚硝酸钠(nano 2)和n-卤代琥珀酰亚胺(nxs)在dmf中反应,将芳基胺转化为芳基卤化物的一锅通用方法.建议与桑德迈尔反应互补的这一新方案涉及原位产生的硝基卤化物引起芳基胺的亚硝化反应,形成重氮中间体,将其卤化以提供芳基卤化物.
DOI:10.1002/chem.201803347

专利信息

专利号:US-2006052577-A1
优先权日:2001-02-06
标题:Methods of synthesis of polymers and copolymers from natural products
发明人：SWIFT GRAHAM; WESTMORELAND DAVID G; HUGHES KATHLEEN
权利人:SWIFT GRAHAM; WESTMORELAND DAVID G; HUGHES KATHLEEN
摘要:Described are polymers and copolymers containing sorbitol, citric acid, starch, aspartic acid, succinic anhydride, adipic acid mixtures thereof, methods of their synthesis and their uses.

专利号:US-2002192767-A1
优先权日:1999-10-13
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli . Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-02068613-A1
优先权日:2001-02-28
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
权利人:UNIV LELAND STANFORD JUNIOR; KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-8193360-B2
优先权日:2003-07-31
标 题:Radiolabelled fluorobenzamide analogues, their synthesis and use in diagnostic imaging
发明人：MACH ROBERT H; TU ZHUDE
权利人:MACH ROBERT H; TU ZHUDE; UNIV WASHINGTON
摘要:Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18 F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123 I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

专利号:WO-2013117440-A1
优先权日:2012-02-09
标 题 :Synthesis of water-soluble phosphine oxides by pd/c-catalyzed p-c coupling in water
发明人：RANOCCHIARI MARCO; RUMMELT STEPHAN; VAN BOKHOVEN JEROEN A
权利人:SCHERRER INST PAUL
摘要:Cross-coupling between diphenylphosphine oxide and halogenated benzoic acids catalyzed by Pd/C in water is a green, simple and fast protocol to obtain water-soluble tertiary phosphine oxides without the addition of ligands and additives. Low reaction times, microwave irradiation, and high substrate scope make this method general and excellent for lab- and large-scale synthesis without the need to use organic solvents for neither reaction nor workup.

专利号:US-2010063301-A1
优先权日:2006-03-15
标题 :Synthesis of thrombopoietin activity modulating compounds
发明人：PHILLIPS DEAN
权利人:LIGAND PHARM INC
摘要:Disclosed herein are various methods for synthesizing compounds that modulate thrombopoietin activity. Also disclosed are intermediates useful for the preparation of these compounds.