CAS: 629-25-4; Sodium Dodecanoate

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专利信息

专利号:US-2020087149-A1
优先权日:2015-07-22
标 题 :Method for the synthesis of nanofluids
发明人：TALAEI ZEINAB; RASHIDI ALIMORAD; AMROLLAHI BIYOUKI AZADEH; MAHJOUB ALLREZA; LOTFI ROGHAYYEH; RASHTCHI MARYAM
权利人:RES INSTITUTE OF PETROLEUM INDUSTRY
摘要:The present invention relates to a method for the synthesis of nanofluids including functionalization of carbon nanostructures through a new method comprising the addition of carbon nanostructures to water; ultrasonication of the solution; addition of persulfate salt and one or several metal hydroxides of the first column of the periodic table to the aqueous solution containing carbon nanostructure; re-exposing the solution to ultrasonic waves; and then, the separation of the functionalized carbon nanostructures from the solution and washing the carbon nanostructures with water to neutralize them and mixing the nanoparticles obtained from the previous step with the fluid. By presenting a new method for the synthesis of the functionalized carbon nanostructures with specific amount of functional groups and their application in the synthesis of nanofluids, an increase in the stability and thermal conductivity of nanofluids takes place.

专利号:US-2005069551-A1
优先权日:2002-03-08
标题 :Cytotoxic compound-protein conjugates as suppressors of tumor growth and angiogenesis
发明人：SHOJI MAMORU; SNYDER JAMES P; LIOTTA DENNIS C; SUN AIMING
权利人:UNIV EMORY
摘要:Compositions and methods are provided for delivering cytotoxic compounds, such as natural curcumoids and synthetic curcumin analogs, specifically to cancer cells and to blood vessels that nourish solid tumors. The compositions include a cytotoxic drug tethered to a protein, such as factor VIIa, which can bind with high affinity to a receptor, such as tissue factor, expressed on the surface of cancer cells and vascular endothelial cells within the tumor microenvironment. Upon binding, the drug-protein-receptor complex is endocytosed and the drug is subsequently liberated inside the target cell via proteolytic cleavage. The compositions and methods may increase the efficacy of the cytotoxic agets and decrease their side effects by delivering the agents to specific target cells, such as cancer cells, vascular endothelial cells in a tumor, and metastatic foci anywhere in the body, providing the target cells express surface bound tissue factor. Additionally, methods of synthesis of cytotoxic compound-protein conjugates are provided, for example, curcuminoid-tether-linker-factor VIIa composition, as well as pharmaceutically acceptable compositions and methods for delivering a therapeutically-effective amount of a cytotoxic compound-protein conjugate together with one or more pharmaceutically acceptable carriers (additives) and/or diluents to an animal or human patient.

专利号:US-8236960-B2
优先权日:2004-09-27
标 题 :Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms
发明人：THYGESEN MIKKEL BOAS; SCHLIENGER NATHALIE; TOLF BO-RAGNAR; ANDERSSON CARL-MAGNUS A; BLATTER FRITZ; BERGHAUSEN JOERG
权利人:THYGESEN MIKKEL BOAS; SCHLIENGER NATHALIE; TOLF BO-RAGNAR; ANDERSSON CARL-MAGNUS A; BLATTER FRITZ; BERGHAUSEN JOERG; ACADIA PHARM INC
摘要:Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl) -N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2 -methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.

专利号:US-8575081-B2
优先权日:2008-01-31
标 题:Synthesis of diester-based biolubricants from epoxides
发明人：MILLER STEPHEN JOSEPH; ZHOU ZHEN; ELOMARI SALEH A
权利人:MILLER STEPHEN JOSEPH; ZHOU ZHEN; ELOMARI SALEH A; CHEVRON USA INC
摘要:The present invention is generally directed to methods of making diester-based lubricant compositions, wherein formation of diester species proceeds via direct esterification of epoxide intermediates. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor and/or low value (e.g., Fischer-Tropsch (FT) olefins and/or alcohols) so as to produce high value diester-based lubricants. In some embodiments, such diester-based lubricants are derived from FT olefins and fatty acids. The fatty acids can be from a bio-based source (i.e., biomass, renewable source) or can be derived from FT alcohols via oxidation.

专利号:US-7598403-B2
优先权日:2003-05-16
标 题 :Synthesis of chromanones
发明人：SALVATORE BRIAN A; SOLIS FERDINAND C
权利人:UNIV SOUTH CAROLINA RES FOUND
摘要:Processes for the preparation of biologically active chromanones are disclosed, including processes for the preparation of intermediates useful in the preparation of the biologically active chromanones. The chromanones and the intermediates disclosed herein may be useful for a variety of therapies, including the treatment of various cancers and the treatment of inflammation and inflammation related disorders.

专利号:US-7498434-B2
优先权日:2004-01-14
标题:Two-phase method for the synthesis of selected pyrazolopyrimidines
发明人：CANTRELL GARY LEE; MOSER FRANK WILLIAM; HALVACHS ROBERT EDWARD
权利人:MALLINCKRODT INC
摘要:An improved method of making a substituted pyrazolopyrimidine. The method comprises reacting a aminopyrazole compound or a salt thereof with a substituted 1-oxo-2-propenyl-arene(-heterocycle) or a salt thereof under acidic conditions in a reaction medium including a two-phase mixture of an aqueous solution and a water-immiscible organic liquid. Specific substituted pyrazolopyrimidines include N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide and N-methyl-N-(3-{3-[2-thienyl-carbonyl]-pyrazolo[1,5-a]-pyrimidin-7-yl}phenyl)acetamide.