CAS: 6427-66-3; 4-Azidobenzoic Acid

该化合物是一种有机化合物,其特征是附于苯环的有功能组(-N3)和碳盒酸组(-COOH),其分子结构包括以基组和碳盒酸位置替换在副位置的苯环,该化合物一般是白到光黄色晶状固体,在水和酒精等极地溶剂中溶解. 4-Azidobenzoic酸因其反应性而闻名,特别是在点击化学应用中,在这种应用中,酸组可以参与循环反应,还用于各个领域,包括材料科学和生物化学,因为它能够作为联动剂或作为其他功能化化合物合成的前体.在处理该物质时,应当采取安全防范措施,因为在某些条件下,可能是爆炸性的.

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上下游产品

(E)-3-(4-azidophenyl)acrylic acid 4-amino-benzoic acid methyl 2,3-O-isopropylidene-5-O-(p-nitrobenzoyl)-β-D-ribofuranoside ammonia 4-triphenylphosphoranylidenamino-benzoic acid 2-methyl-6-benzoxazole carboxylic acid 4-azidobenzoic acid N-hydroxysuccinimide ester b,Ne-di-B°C-L-lysine-triamideN-(p-Azidobenzamido)-O-B°C-L-tyrosyl-di-B°C-spermine-Nb,Ne-di-B°C-L-lysine-triamide

合成工艺路线路线简述

  • 合成目标产物 4-Azidobenzoic Acid 主要起始原料 4-Aminobenzoic Acid
  • (文献来源)合成步骤主要原料 4-Aminobenzoic Acid
对氨基苯甲酸置于硫酸,Sodium Nitrite,Sodium Azide体系中,用 水 作为反应溶剂,化学反应 2.17H,以96%的收率获得产物对叠氮苯甲酸
参考文献:使用稀释和未稀释的硫酸盐离子液体从模拟的辐照铀铝靶浸出液中分离钼(vi)
标题:使用稀释和未稀释的硫酸盐离子液体从模拟的辐照铀铝靶浸出液中分离钼(vi)
摘要:提出了一种将钼与通常存在于辐照过的铀铝靶材的氧化碱性浸出液中的其他元素分离的方法,以生产钼99.分离是通过使用三氮唑鎓和硫酸离子液体萃取剂(在1-辛醇中稀释或未稀释)选择性萃取钼酸根阴离子来完成的.然后使用碳酸氢钠溶液从有机相中汽提钼.通过使有机相与碱性硫酸盐溶液接触来再生萃取剂.研究了萃取机理和稀释剂对萃取剂性能的影响.报道的方法为最先进的色谱方法提供了有希望的替代方法,显示了限制放射性废物产生的潜力.
DOI:10.1039/c9Gc01626K

海关参考信息

专利信息


专利号:US-8017323-B2
优先权日:2003-03-26
标 题 :Free reactant use in nucleic acid-templated synthesis
发明人:LIU DAVID R; SAKURAI KAORI
权利人:HARVARD COLLEGE
摘要:The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses. In particular, nucleic acid-templated chemistries are used to produce reaction intermediates attached to an oligonucleotide that can be used to identify the reaction intermediates and/or the resulting reaction products. The reaction intermediates then are reacted with free reactants (for example, reactants that are difficult or impractical to couple to an oligonucleotide) to produce a reaction product. This approach expands the scope of reagents useful in nucleic acid-templated syntheses to reagents that do not need to be or cannot be tethered to an oligonucleotide. The reagents, however, still permit the synthesis of reaction products attached to oligonucleotides that can be used to identify the reaction products.

专利号:US-7151112-B1
优先权日:2001-09-04
标题:Pharmaceutical uses and synthesis of nicotinamides
发明人:CUTSHALL NEIL S; JEFFREY SCOTT C
权利人:UCB SA
摘要:This invention is directed to methods of using a compound of the formula n nand pharmaceutically acceptable salts thereof, wherein n, X, R 1 and R 2 are disclosed herein, for treating inflammatory events in an animal subject.

专利号:US-2023295613-A1
优先权日:2020-02-14
标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming
发明人:JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:US-11814621-B2
优先权日:2018-06-01
标题 :Expanding the chemical substrates for genetic code reprogramming
发明人:JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; MOORE JEFFREY S; SCHWIETER KENNETH E; SCHWARZ KEVIN JEROME
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:US-6072060-A
优先权日:1993-02-05
标题:Synthesis of taxol, taxol analogs and their intermediates with variable A-ring side chain structures and compositions thereof

专利号:EP-0348490-B1
优先权日:1988-01-11
标题 :Treatment of type 2 diabetes mellitus
发明人:COOPER GARTH JAMES SMITH; GREENE HOWARD E
权利人:AMYLIN PHARMACEUTICALS INC
摘要:Compounds and methods for blocking the effects of diabetes-associated peptide, or ''amylin'', a hormone found in the amyloid masses of Type 2 diabetics. Also disclosed are methods of identifying additional compounds having utility for the treatment of Type 2 diabetes. This putative hormone has been discovered to function both to inhibit insulin secretion and to inhibit glycogen synthesis. Regulation is accomplished by blocking the binding of amylin or amylin agonists, including calcitonin gene related peptide (CGRP), or biologically active sub-peptides thereof. Inhibitors include substituted peptides or sub-peptides of amylin or CGRP, cross-linked amylin and amylin agonists, synthetic amylin, anti-amylin receptor antibodies and anti-idiotype antibodies, and antibodies directed to amylin and amylin agonist active sites. Other antagonists include organic compounds which can be screened and assayed for anti-amylin effects by disclosed methods.
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合成参考文献


摘要:Monguchi, Y.; Sajiki, H., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 360.
参考文献:10.1023/a:1009225811420
摘要:Salah el Din AL, Braun V, Abdallah MA. Synthesis and activity of p-azidobenzoyloxyferricrocin, a photoactivatable analog of ferrichrome. Biometals. 1999 Jun;12(2):151–60. doi: 10.1023/a:1009225811420.
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