CAS: 69045-84-7; 2,3-Dichloro-5-(Trifluoromethyl)Pyridine

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4-Formyl-2,4-Dichloro-5,5,5-Trifluorovaleronitrile 反应生成 2,3-二氯-5-三氟甲基吡啶
参考文献:Process For The Production Of Chloropyridines Substituted By Methyl,
标题:Process For The Production Of Chloropyridines Substituted By Methyl,
摘要:公式为##str1##的氯吡啶,其中r为氯且r'为甲基或三氟甲基,或r为甲基,三氯甲基或三氟甲基且r'为氯,或r和r'为甲基,可通过一种新颖简单的方法获得,即将三氯乙醛加入甲基丙烯腈或α-三氟甲基丙烯腈,2,2-二氯丙醛,五氯丙醛或2,2-二氯-3,3,3-三氟丙醛加入丙烯腈,或将2,2-二氯丙醛加入甲基丙烯腈,在催化剂的存在下,特别是在铜粉或氯化铜(I)的存在下,并使得得到的开链中间体环化.公式(I)的氯吡啶本身是已知的,并适用于生产不同化合物,特别是杀虫剂和除草剂的生产.

专利信息

专利号:US-2009076268-A1
优先权日:2007-09-14
标 题:Facile assembly of fused benzofuro-heterocycles
发明人：FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
权利人:FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
摘要:This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization.

专利号:US-7812161-B2
优先权日:2007-03-05
标 题 :Synthesis of GlyT-1 inhibitors
发明人：PFLEGER CHRISTOPHE; WALDMEIER PIUS; WANG SHAONING
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a process for preparation of a compound of formula I n nwhereinn Het, R 1 , R 2 , R 3 , and n are as defined herein and pharmaceutically acceptable acid addition salts thereof, which comprises reacting a compound of formula 21 with a compound of formula 8 to obtain a compound of formula 11 and coupling the compound of formula 11 in the presence of a coupling reagent or the corresponding acid halogenide with a compound of formula 15 to obtain a compound of formula I.

专利号:WO-2024013736-A1
优先权日:2022-07-12
标题 :Process for preparing substituted benzamides
发明人：HAMIRANI BHAVINKUMAR; MAHESH GANDHAM; SREEDEVI MANNAM; PILLAI BIJUKUMAR GOPINATHAN
权利人:ADAMA MAKHTESHIM LTD
摘要:The present invention relates to new intermediates for the preparation of pyridylmethylbenzamides via substituted hydroxyiminopyridines or acetamidopyridines, and their innovative preparation processes. The invention discloses, in particular, the total synthesis of fluopicolide fungicide. The preparation of the main substances of the fluopicolide synthesis, specifically, substituted pyridine-2-ylmethanamine or its salt, is disclosed via two different synthesis routes, comprises two novel substances.

专利号:US-4349681-A
优先权日:1979-12-24
标题:2-Amino-3-chloro-5-trifluoromethylpyridine
发明人：YOKOMICHI ISAO; HAGA TAKAHIRO; NAGATANI KUNIAKI; NAKAJIMA TOSHIO
权利人:ISHIHARA MINING & CHEMICAL CO
摘要:A novel compound, 2-amino-trifluoromethyl-halogenopyridine, is provided, which is prepared by amination of a 2-halogeno-trifluoromethyl-halogenopyridine or by halogenation of 2-amino-trifluoromethylpyridine. This compound is useful as an intermediate for synthesis of agricultural chemicals and medicines.

专利号:WO-2008107334-A2
优先权日:2007-03-05
标题:Process for the synthesis of glyt-1 inhibitors

专利号:AU-2008223915-A1
优先权日:2007-03-05
标题:Process for the synthesis of GLYT-1 inhibitors