CAS: 80-09-1; 4,4'-Sulfonyldiphenol

• 英文名称4,4'-Sulfonyldiphenol
• 中文名称双酚 S
• IUPAC名称4,4'-sulfonyldiphenol
• 其它别名Di-(4-Hydroxyphenyl)Sulfone; 4,4'-Dihydroxydiphenyl Sulphone; 4,4'-Sulfonylbis[phenol]; Bis(P-Hydroxyphenyl) Sulfone; Inchi=1/c12H10O4S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-
• CAS编号80-09-1
• MFCD编号:MFCD00002350
• EINECS号:201-250-5
• 分子式:C12H10O4S
• 分子量:250.27
• 产品CID: 2362126
• 产品分类化学试剂 → 有机试剂 → 砜、亚砜类化合物

• 相似结构搜索
• InChIKey: VPWNQTHUCYMVMZ-UHFFFAOYSA-N
• InChI=1S/C12H10O4S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8,13-14H…
• 计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数2.0

物理性质

• 熔点245-250  °C(文献)
• 沸点505.3±35.0 °C at 760 mmHg
• 闪点259.4±25.9 °C
• 密度1.4±0.1 g/cm3
• PH:6.6-7.0 (100g/l, H2O, 20°C)
• pKa:7?+-.0.15(预测)
• PSA:82.98
• LogP:1.83
• 折射率1.645
• 蒸汽压0.0±1.3 mmHg at 25°C
• 溶解性1.1G/l
• 敏感性本品分子中含两个羟基和一个吸电子很强的砜基，故酸性比其他酚类强。具有耐热、耐氧化性及光稳定性。
• 外观形态白色至灰绿色结晶粉末
• 储存条件存储低于 +30°C.
• 产品应用4,4'-二羟基二苯砜主要用作固色剂.此外,可用作镀液添加剂,皮革鞣剂,分散染料高温染色的分散剂,酚醛树脂硬化促进剂,树脂阻燃剂等.也是农药,染料,助剂的中间体.作为双酚A的代用品,可作为聚碳酸酯,环氧树脂,聚酯,酚醛树脂的原料,以及聚砜,聚醚砜的原料.该品也用于制造彩色摄影材料,照相反差增强剂,热敏记录材料(显色剂),日用表面活性剂和高效除臭剂等.以双酚S为原料可制取固色剂A(国外商品名为CibatexPA).搬运及储藏:搬运后需彻底清洗全身.去除受污染的衣物并在再次使用前进行清洗.用途1 主要用作合成聚砜树脂的单体,也可直接应用于涂料,皮革改性剂,染料中间体,金属电镀亮光剂等用途2 4,4'-二羟基二苯砜主要用作固色剂.此外,可用作镀液添加剂,皮革鞣剂,分散染料高温染色的分散剂,酚醛树脂硬化促进剂,树脂阻燃剂等.也是农药,染料,助剂的中间体.作为双酚A的代用品,可作为聚碳酸酯,环氧树脂,聚酯,酚醛树脂的原料,以及聚砜,聚醚砜的原料.该品也用于制造彩色摄影材料,照相反差增强剂,热敏记录材料(显色剂),日用表面活性剂和高效除臭剂等.
• 性质描述白色针状结晶.熔点240-241°C.易溶于脂肪烃,溶于醇和醚,微溶于芳烃,难溶于水.该品分子中含两个羟基和一个吸电子很强的砜基,故酸性比其他酚类强.

MSDS等安全信息

• GHS象形图
• GHS符号GHS08;
  注释: Health hazard
• 危险类别生殖毒性 类别1B
  ED HH 1
  ED ENV 1
  严重眼刺激 类别2
  水生慢性毒性 类别3
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  生殖毒性 类别2
• 警示词Danger(危险)
• 危险描述H360FD |可能损害生育能力. 可能对胎儿造成损害.
  EUH380 |May cause endocrine disruption in humans
  EUH430 |May cause endocrine disruption in the environment
  H360 |可能损害生育能力或胎儿.
  H319 |造成严重眼刺激.
  H412 |对水生生物有害并具有长期持续影响.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H361 |怀疑对生育能力或胎儿造成损害.
• 防范说明P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P273-P280-P305+P351+P338+P337+P313-P501
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明26-39-36-37
• 危险类别码36-36/37/38
• WGK Germany2

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 Bis(4-Hydroxyphenyl) Sulfone 主要起始原料 Phenol
• 2664-63-3 = 80-09-1
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 2732900-19-3 (Bonded To Fe3O4) Solvents: Acetonitrile; 440 Min,35 °C
  标题:Schiff Base Complex Of Mo Supported On Iron Oxide Magnetic Nanoparticles (Fe3O4) As Recoverable Nanocatalyst For The Selective Oxidation Of Sulfides
  作者:Aghajani,Milad; Et Al
  参考文献:Journal Of The Iranian Chemical Society 日期:2017 卷标:14(5) 页码:963-975]
  
  98-67-9 = 80-09-1
  反应条件:1.1 Reagents: Sulfuric Acid
  标题:Synthesis Of Some Esters Of 4,4'-Dihydroxydiphenyl Sulfone And Carboxylic Acids
  作者:Baranov,S. N.; Et Al
  参考文献:Zhurnal Obshchei Khimii 日期:1958 卷标:28 页码:1274-6]
  
  25667-42-9 = 80-09-1
  反应条件:1.1 Reagents: 1,3-Dimethyl-2-Imidazolidinone,Cesium Hydroxide; 4 H,150 °C; 150 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
  标题:Hydroxylation-Depolymerization Of Oxyphenylene-Based Super Engineering Plastics To Regenerate Arenols
  作者:Minami,Yasunori; Et Al
  参考文献:Jacs Au 日期:2023 卷标:3(8) 页码:2323-2332]
  
  37181-39-8 = 80-09-1
  反应条件:1.1 Reagents: Acetohydroxamic Acid,Potassium Carbonate Solvents: Dimethyl Sulfoxide; 20 Min,Rt1.2 Rt -> 80 °C; 12 H,80 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3
  标题:Synthesis Of Phenols From Aryl Ammonium Salts Under Mild Conditions
  作者:Ni,Pufan; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(19) 页码:12677-12687]
  
  37181-39-8 = 80-09-1
  反应条件:1.1 0 °C; 0 °C -> Rt; 30 Min,Rt2.1 Solvents: Dichloromethane; Rt; Overnight,Rt3.1 Reagents: Acetohydroxamic Acid,Potassium Carbonate Solvents: Dimethyl Sulfoxide; 20 Min,Rt3.2 Rt -> 80 °C; 12 H,80 °C3.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3
  标题:Synthesis Of Phenols From Aryl Ammonium Salts Under Mild Conditions
  作者:Ni,Pufan; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(19) 页码:12677-12687]
  
  80-08-0 = 80-09-1
  反应条件:1.1 Reagents: Sodium Cyanoborohydride Solvents: Acetic Acid; Overnight,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,0 °C2.1 Solvents: Dichloromethane; Rt; Overnight,Rt3.1 Reagents: Acetohydroxamic Acid,Potassium Carbonate Solvents: Dimethyl Sulfoxide; 20 Min,Rt3.2 Rt -> 80 °C; 12 H,80 °C3.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3
  标题:Synthesis Of Phenols From Aryl Ammonium Salts Under Mild Conditions
  作者:Ni,Pufan; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(19) 页码:12677-12687]
  
  2664-63-3 = 80-09-1 + 1774-34-1
  反应条件:1.1 Reagents: Sodium Periodate Catalysts: Imidazole,Silica,(Sp-5-12)-Chloro[2,3,7,8,12,13,17,18-Octabromo-5,10,15,20-Tetraphenyl-21H,23H-Po... Solvents: Acetonitrile,Water; Rt; 10 Min,Rt -> 40 °C
  标题:Highly Efficient Oxidation Of Sulfides With Sodium Periodate Catalyzed By Reusable Silica Supported Mn(Br8Tpp)Cl And Mn(Tpp)Cl Catalysts Under Various Reaction Conditions
  作者:Mirkhani,Valiollah; Et Al
  参考文献:Applied Catalysis 日期:2009 卷标:353(1) 页码:61-67]
  
  2664-63-3 = 80-09-1 + 1774-34-1
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Trifluoromethanesulfonic Acid,Sodium Tungsten Oxide (Na2Wo4) Solvents: Methanol; 2 H,30 °C
  标题:Sulfoxidation Inside A Hypercrosslinked Microporous Network Nanotube Catalyst
  作者:Shi,Zhaocheng; Et Al
  参考文献:New Journal Of Chemistry 日期:2020 卷标:44(4) 页码:1542-1547]
  
  2664-63-3 = 80-09-1 + 1774-34-1
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 2732900-19-3 (Bonded To Fe3O4) Solvents: Ethanol; 570 Min,Rt
  标题:Schiff Base Complex Of Mo Supported On Iron Oxide Magnetic Nanoparticles (Fe3O4) As Recoverable Nanocatalyst For The Selective Oxidation Of Sulfides
  作者:Aghajani,Milad; Et Al
  参考文献:Journal Of The Iranian Chemical Society 日期:2017 卷标:14(5) 页码:963-975]
  
  25839-81-0 = 80-09-1 + 92-88-6
  反应条件:1.1 Reagents: 1,3-Dimethyl-2-Imidazolidinone,Calcium Hydride,Cesium Hydroxide; 19 H,150 °C; 150 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
  标题:Hydroxylation-Depolymerization Of Oxyphenylene-Based Super Engineering Plastics To Regenerate Arenols
  作者:Minami,Yasunori; Et Al
  参考文献:Jacs Au 日期:2023 卷标:3(8) 页码:2323-2332]
  
  25667-42-9 = 80-09-1 + 154221-98-4
  反应条件:1.1 Reagents: 1,3-Dimethyl-2-Imidazolidinone,Calcium Hydride,Cesium Hydroxide; 19 H,150 °C; 150 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
  标题:Hydroxylation-Depolymerization Of Oxyphenylene-Based Super Engineering Plastics To Regenerate Arenols
  作者:Minami,Yasunori; Et Al
  参考文献:Jacs Au 日期:2023 卷标:3(8) 页码:2323-2332]
  
  = 80-09-1
  反应条件:1.1 Reagents: 1,3-Benzenedisulfonic Acid,Sulfuric Acid Solvents: Mesitylene
  标题:Preparation Of Highly Pure 4,4'-Dihydroxydiphenyl Sulfone.
  参考文献:Japan]
  
  2664-63-3 = 80-09-1
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Bis(Acetylacetonato)Dioxomolybdenum (Supported On Imine-Functionalized Zeolite H-Beta); 50 Min,Rt
  标题:Efficient Molybdenum Catalyzed Chemoselective,Solvent-Free Oxidation Of Sulfides To Sulfones At Room Temperature
  作者:Hadigavabar,Ali Dadashi; Et Al
  参考文献:Journal Of The Chilean Chemical Society 日期:2018 卷标:63(1) 页码:3829-3833]
  
  2664-63-3 = 80-09-1
  反应条件:1.1 Reagents: Water,N-Fluorobenzenesulfonimide; 24 H,Rt
  标题:Selective Synthesis Of Sulfoxides And Sulfones Via Controllable Oxidation Of Sulfides With N-Fluorobenzenesulfonimide
  作者:Xu,Xiaobo; Et Al
  参考文献:Organic & Biomolecular Chemistry 日期:2021 卷标:19(40) 页码:8691-8695]
  
  98-67-9 = 80-09-1
  反应条件:1.1 Solvents: Isopropanol,Isoamyl Alcohol; 1 H,60 °C
  标题:Study On Water Removal Control In Synthesis And Purification Of Bisphenol S
  作者:Zhang,Tianyong; Et Al
  参考文献:Huaxue Tongbao 日期:2016 卷标:79(3) 页码:259-263]
  
  = 80-09-1 [标题:Reaction Conditions
  标题:Highly Pure 4,4'-Dihydroxydiphenyl Sulfone
  参考文献:World Intellectual Property Organization]
  
  80-09-1 = 80-09-1
  反应条件:1.1 Reagents: Triethylamine,Hexachlorocyclotriphosphazene Solvents: Acetone,Toluene; 5 H,40 °C
  标题:Studies Of Selective Detection Of Picric Acid In Solution Phase Using Fluorescent Polyphosphazene Nanofibers
  作者:Wei,Wei; Et Al
  参考文献:Gaofenzi Xuebao 日期:2015 卷标:(12) 页码:1477-1485]
  
  1774-34-1 = 80-09-1
  反应条件:1.1 Reagents: Potassium Bicarbonate,Sodium Carbonate,Potassium Carbonate Solvents: Water; 126.76 Min,0 °C1.2 16 H,0 °C
  标题:Concentrated Aqueous Peroxodicarbonate: Efficient Electrosynthesis And Use As Oxidizer In Epoxidations,S-,And N-Oxidations
  作者:Seitz,Ann-Katrin; Et Al
  参考文献:Angewandte Chemie 日期:2022 卷标:61(25)]
  
  = 80-09-1
  反应条件:1.1 Reagents: Diisopropylethylamine,Potassium Pyrosulfite Catalysts: Palladium Diacetate,Tri-Tert-Butylphosphonium Tetrafluoroborate Solvents: Dimethylformamide; Rt -> 100 °C; 20 H,100 °C
  标题:Palladium-Catalyzed One-Step Synthesis Of Symmetrical Diaryl Sulfones From Aryl Halides And A Sulfur Dioxide Surrogate
  作者:Tanaka,Hiromichi; Et Al
  参考文献:Chemistry Letters 日期:2019 卷标:48(8) 页码:760-763]
  
  = 80-09-1
  反应条件:1.1 Reagents: Diisopropylethylamine,Potassium Pyrosulfite Catalysts: Palladium Diacetate,Tri-Tert-Butylphosphonium Tetrafluoroborate Solvents: Dimethylformamide; Rt -> 100 °C; 20 H,100 °C
  标题:Palladium-Catalyzed One-Step Synthesis Of Symmetrical Diaryl Sulfones From Aryl Halides And A Sulfur Dioxide Surrogate
  作者:Tanaka,Hiromichi; Et Al
  参考文献:Chemistry Letters 日期:2019 卷标:48(8) 页码:760-763]
  
  33871-62-4 + 333-27-7 = 80-09-1
  反应条件:1.1 Solvents: Dichloromethane; Rt; Overnight,Rt2.1 Reagents: Acetohydroxamic Acid,Potassium Carbonate Solvents: Dimethyl Sulfoxide; 20 Min,Rt2.2 Rt -> 80 °C; 12 H,80 °C2.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3
  标题:Synthesis Of Phenols From Aryl Ammonium Salts Under Mild Conditions
  作者:Ni,Pufan; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(19) 页码:12677-12687]
  
  71597-85-8 + 637-89-8 = 80-09-1
  反应条件:1.1 Catalysts: 2,2′-Bipyridine,Nickel Dichloride Solvents: Dimethylformamide,Acetonitrile; 5 Min,Rt1.2 Reagents: Potassium Tert-Butoxide; Rt; 12 H,Rt1.3 Reagents: Ammonium Chloride Solvents: Water2.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene,Hydrogen Peroxide Catalysts: Zinc Chloride Solvents: Methanol; Rt; 16 H,80 °C
  标题:Room Temperature Nickel-Catalyzed Cross-Coupling Of Aryl-Boronic Acids With Thiophenols: Synthesis Of Diarylsulfides
  作者:Bhowmik,Amit; Et Al
  参考文献:Organic & Biomolecular Chemistry 日期:2020 卷标:18(13) 页码:2447-2458]
  
  = 80-09-1 + 5397-34-2
  反应条件:1.1 Reagents: Sulfuric Acid,Phosphonic Acid Solvents: 1,2,4-Trimethylbenzene
  标题:Liquid-Crystal Aromatic Polyesters Containing Azo And Sulfone Units
  作者:Qiu,Ming Yan; Et Al
  参考文献:Asian Journal Of Chemistry 日期:2014 卷标:26(22) 页码:7759-7762

海关参考信息

• 2908199090-其他酚的卤化衍生物
  2908999090-其他酚的硝化衍生物
  2918290000-其他含酚基羧酸
  2905199090-其他饱和一元醇
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• 详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管