专利号:US-2014234364-A1 优先权日:2011-09-23 标 题:Total synthesis and immunological evaluation of saccharide moieties of the lipopolysaccharide from neisseria meningitidis 发明人:SEEBERGER PETER H; YANG YOU; ANISH CHAKKUMKAL; REINHARDT ANIKA 权利人:MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V 摘要:The present invention relates to the total chemical synthesis of the monosaccharide 35 # (R′â•?H), the disaccharide 36 # (R′≠H; R″â•?H), the trisaccharide 37 # (R′≠H; R″≠H; R′″≠H) and the tetrasaccharide 1 # (R′≠H; R″≠H; R′″≠H) of the following general formula wherein R represents —Y—NH 2 Y represents a linker R′ is H or R″ is H or R′″ is H or of the lipopolysaccharide from Neisseria meningitidis , as well as to the trisaccharide 37 # and the tetrasaccharide 1 # , to vaccines containing at least one of the saccharides 1 # , 35 # , 36 # , and 37 # and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide α-GlcNAc-(1→2)-α-Hep-( 1→3 )-α-Hep-(1→5)-α-Kdo or the trisaccharide α-Hep-(1→3)-α-Hep-(1→5)-α-Kdo or α-GlcNAc-(1→2)-±-Hep-(1→3)-α-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.
专利号:US-10519108-B2 优先权日:2015-09-17 标 题:Inhibitors of retinaldehyde dehydrogenases and methods of use 发明人:SUMMERS JODY A; HARPER ANGELICA R; MATHER TIM; BURGETT ANTHONY; LE ANH THI QUYNH 权利人:UNIV OKLAHOMA; OKLAHOMA MED RES FOUND 摘要:Compounds having inhibitory activity against retinaldehyde dehydrogenases (RALDHs). The compounds can be used, for example, to inhibit synthesis of retinoic acid for the treatment of refractive error disorders such as myopia, and as infertility treatments by inhibiting spermatogenesis.
专利号:US-8034908-B2 优先权日:2003-02-14 标 题:Glycolipids and synthetic method thereof as well as their synthetic intermediates, and synthetic method thereof 发明人:ANNOURA HIROKAZU; MURATA KENJI; YAMAMURA TAKASHI 权利人:JAPAN GOVERNMENT 摘要:Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient synthetic methods for practical mass production of the same and intermediates useful for the synthesis of these compounds. n Glycolipids having the formula (I): n nwhere R 3 indicates a substituted or unsubstituted C 1 to C 7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R 8 indicates a substituted or unsubstituted C 1 to C 35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group are chemically synthesized.
专利号:US-5753751-A 优先权日:1996-10-24 标 题 :Process for preparing self-curable alkenyl hydride siloxane copolymers and coating composition 发明人:LIAO WEN P; NYE SUSAN A 权利人:GEN ELECTRIC 摘要:A sequential catalysis of the ring opening polymerization of cyclic organosiloxanes using a base catalyst that can be neutralized by a subsequent redistribution and condensation Lewis acid catalyst, preferably a phosphonitrilic compound, permits the rapid synthesis of functionalized and poly-functionalized silicone copolymers such as alkenyl hydride copolymers, a new composition of matter, which is a one component curable silicone by means of hydrosilylation or peroxide initiated free radical polymerization. The alkenyl hydride copolymer is formulated into a curable composition, emulsified and coated onto an automobile airbag and subsequently cured.
专利号:CN-1518536-A 优先权日:2001-05-04 标 题 :Labelling reagents, method for synthesis of said reagents and methods for detecting biological molecules
专利号:KR-20110018886-A 优先权日:2008-04-30 标 题:Synthesis of timosaponin bii
[参考文献]: Ana Vuli, Et Al. Mutagenicity And Dna-Damaging Potential Of Clenbuterol And Its Metabolite 4-Amino-3,5-Dichlorobenzoic Acid In Vitro. Food Chem Toxicol. 2015 Mar:77:82-92. [参考文献]: Catherine Kamtchueng, Et Al. Alternative Splicing Of Taf6: Downstream Transcriptome Impacts And Upstream Rna Splice Control Elements. Plos One. 2014 Jul 15;9(7):E102399. [参考文献]: Flora Tolentino, Et Al. In Vivo Evaluation Of The Genetic Toxicity Of Rubus Niveus Thunb. (Rosaceae) Extract And Initial Screening Of Its Potential Chemoprevention Against Doxorubicin-Induced Dna Damage. J Ethnopharmacol. 2015 Apr 22:164:89-95. [参考文献]: Francesca Chianini, Et Al. Correlation Between Infectivity And Disease Associated Prion Protein In The Nervous System And Selected Edible Tissues Of Naturally Affected Scrapie Sheep. Plos One. 2015 Mar 25;10(3):E0122785. [参考文献]: J J Padilla-Frausto, Et Al. Detection And Genotyping Of Leuconostoc Spp. In A Sausage Processing Plant. J Food Prot. 2015 Dec;78(12):2170-6.
合成参考文献
参考文献:10.1186/1746-4811-7-22 摘要:Tsugama D, Liu S, Takano T. A rapid chemical method for lysing Arabidopsis cells for protein analysis. Plant Methods. 2011 Jul 15;7():22.