3,3-二甲基丁酰氯置于lithium Aluminium Tetrahydride,氨体系中,用 四氢呋喃 用作溶剂,化学反应 18.5H,反应生成3,3-二甲基丁胺 参考文献:A New Quadruply Bound Heterodimer Ddad.aada And Investigations Into The Association Process 标题:A New Quadruply Bound Heterodimer Ddad.aada And Investigations Into The Association Process 摘要: Doi:10.1002/1099-0690(200212)2002:23<4054::Aid-Ejoc4054>3.0.Co;2-H
专利信息
专利号:WO-2016005407-A1 优先权日:2014-07-07 标 题:One-pot synthesis of squaramides 发明人:MÃ?RQUEZ LÓPEZ MARÃ?A EUGENIA; ALEGRE REQUENA JUAN VICENTE; PÉREZ HERRERA RAQUEL 权利人:UNIV ZARAGOZA; CONSEJO SUPERIOR INVESTIGACION 摘要:The present invention refers to the first one-pot synthesis of squaramides. The one-pot synthesis of squaramides described herein is an easy and straightforward procedure to obtain squaramide derivatives which saves energy, avoids time consuming purification steps, reduces costs and provides better yields as compared with those squaramides obtained through the traditional 'stop-and-go' approach. Moreover, the authors of the present invention herein demonstrate the efficiency of this one-pot process with the synthesis of three biologically active structures, improving in most of the cases the results of the previous stepwise syntheses.
专利号:WO-9931124-A1 优先权日:1997-12-12 标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides 发明人:HOEEG-JENSEN THOMAS 权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS 摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.
专利号:US-8299139-B1 优先权日:2009-09-08 标 题:Process and reactor for synthesis of ultra-high molecular weight acrylic polymers 发明人:TARANEKAR PRASAD; SCHUMAN AUSTIN L; BANERJIE ASIS 权利人:TARANEKAR PRASAD; SCHUMAN AUSTIN L; BANERJIE ASIS; OVATION POLYMER TECHNOLOGY AND ENGINEERED MATERIALS INC 摘要:This invention relates to a process for producing high molecular weight (HMW) and ultra-high molecular weight (UHMW) acrylic polymers having unique polymer tacticity and exhibiting enhanced thermal and mechanical properties. This process comprises polymerizing ethylenically unsaturated monomer in the presence of a free radical initiator that results in a “living-like polymerâ€? utilizing a multi-step approach. In conducting the process of this invention the “living-like polymerâ€? is further dissolved in a liquid carrier, wherein the said liquid carrier is a reactive diluent that can be reacted subsequently by an addition polymerization process to create a block- or multi-block, copolymer or homopolymer. This process can be progressively repeated with the same or various different reactive diluents to generate desired architecture and molecular weight polymer(s) which can be used in further processing procedures to be manufactured directly into finished articles.
专利号:US-10772971-B2 优先权日:2017-06-22 标 题:Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates 发明人:GURIJALA VENU REDDY; BOLLU SATYANARAYAN REDDY; LEBLANC JACQUES; LOWINGER TIMOTHY B; MCGILLICUDDY DENNIS; YIN MAO; YURKOVETSKIY ALEKSANDR V 权利人:MERSANA THERAPEUTICS INC; MERSANA THERPEUTICS INC 摘要:The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.
专利号:US-12441677-B2 优先权日:2019-11-14 标 题 :One step synthesis for alkyl 2-fluoroacrylates 发明人:JIN QINGWU; WHITACRE MICHAEL 权利人:VIFOR INT LTD 摘要:A process is provided that results in an alkyl haloacrylate that is produced by reaction of a dialkyl or diaryl halomalonate with an aldehyde, preferably formalin or paraformaldehyde, and a base catalyst to produce an intermediate that is not isolated and is heated to produce the alkyl haloacrylate. This synthesis can be one pot, meaning it reacts in the same vessel and/or reaction mixture and does not require isolation of the intermediate, and provides an improved yield. In particular, a process is provided that results in an alkyl 2-fluoroacrylate.
专利号:US-2017246690-A1 优先权日:2014-06-20 标 题:Stabilizing agent-free metal nanoparticle synthesis and uses of metal nanoparticles synthesized therefrom 发明人:MURPHY RYAN J; DREYFUS REMI; HOUGH LAWRENCE ALAN; MALASSIS LUDIVINE; MURRAY CHRISTOPHER; DONNIO BERTRAND 权利人:RHODIA OPERATIONS; CENTRE NAT RECH SCIENT; UNIV PENNSYLVANIA 摘要:Described herein are methods of synthesizing metal nanoparticles and the metal nanoparticles synthesized therefrom. Further described in the present disclosure are methods of modifying the surfaces of metal nanoparticles and the metal nanoparticles modified thereby. Also described herein are uses of such metal nanoparticles.
摘要:Bagal, D. B.; Bhanage, B. M., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2018) 2, 382. 参考文献:10.1107/s1600536810040705 摘要:Liu J, Wei Z, Wei X, Zhang C. 2-Hydroxy-3-octyloxy-N,N,N-trimethylpropan-1-aminium bromide. Acta Crystallogr E Struct Rep Online. 2010 Oct 20;66(11):o2865. doi: 10.1107/s1600536810040705.