CAS: 22325-27-5; 2-Mercapto-4,6-Dimethylpyrimidine

相似化合物

41840-27-1 1450-85-7 62501-45-5

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4,6-二甲基-1H-嘧啶-2-硫酮盐酸盐置于sodium Carbonate体系中,用 水 用作溶剂,以70%的收率获得4,6-二甲基-2-巯基嘧啶
参考文献:2-Mercapto-4,6-二甲基嘧啶通过 N-Acyl-4,6-二甲基嘧啶-2-硫酮的羧基活化:化学和分光光度法研究
标题:2-Mercapto-4,6-二甲基嘧啶通过 N-Acyl-4,6-二甲基嘧啶-2-硫酮的羧基活化:化学和分光光度法研究
摘要:与分子生物学相关的肽化学在过去的二十年里取得了巨大的进步,并且仍然是一个活跃的研究领域.最近,包括分子生物学,免疫学,药理学,酶学和神经生物学在内的生物医学研究已经确立了其重要性.此外,生物技术的进步为理解生物体的生命过程和健康科学做出了巨大贡献.这些有助于开发新的合成疫苗,可以与细菌和病毒感染,酶机制以及了解神经肽的作用竞争.使用合成肽,研究激素作用机制和酶-底物,抗原-抗体和蛋白质-Dna 相互作用的机制已经成为可能.Du Vigneaud 及其同事合成了oxytoxin 后,肽的合成得到了加速.紧随其后的是混合酸酐,活性酯作为羧基活化基团的引入,以及偶联试剂的发现,这为肽合成的发展提供了前所未有的推动力.当然,在这些方法中,实现了羧基官能团对亲核攻击的高反应性,但需要严格的条件,例如使用碱,温度等.此外,像卤素这样的吸电子基团增强了羧基碳的亲电性,增加了外消旋化的可能性.现在,许多具有巯基功能的杂环系统已被证明对
Doi:10.14233/ajchem.2015.17607

专利信息

专利号:US-5115099-A
优先权日:1988-06-14
标 题:Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates
发明人：KUROIWA KATSUMASA; MATSUURA HITOSHI; KATAYAMA KATSUHIRO; NAKATSUYAMA SHUICHI; NAGASAWA TAKESHI; ENDO KOJI
权利人:NITTO BOSEKI CO LTD
摘要:Novel compounds represented by the following formula: ##STR1## wherein A represents a specific amino acid residue are excellent as substrates for determination of enzyme activity such as trypsin, etc. The compounds can be synthesized from novel arginyl-3-tert-alkyloxycarbonyl-4-nitroanilides by a novel process comprising a selective deprotection step whereby the protecting group on the α-amine group of arginine is removed in the presence of a hydrochloric acid, acetic acid and dimethylformamide mixture, but a tert-alkyl protecting group on the --COOH group of the nitroanilide ring is not removed by this step.

专利号:US-9828386-B2
优先权日:2013-11-15
标题:Sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof
发明人：TANG YAJIE; LI JIANLONG; ZHAO WEI; LI HONGMEI
权利人:UNIV HUBEI TECHNOLOGY
摘要:The present invention discloses a sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof. The present invention introduces a rigid aromatic heterocyclic compound, as well as a further sulfonamidated product of 3-amino-5-mercapto-1,2,4-triazole, 2-amino-5-mercapto-1,3,4-thiadiazole, 4-methylbenzenesulfonyl chloride, or 4-methoxybenzenesulfonyl chloride as a substituent group, into position 4 of the C-ring of podophyllotoxin or 4′-demethylepipodophyllotoxin to obtain the podophyllotoxin derivative shown in formula (V), said derivative having significantly increased antitumor activity and reduced toxic side effects. Experiments on in vitro tumor cell inhibition indicate that the antitumor activity of the compound of formula (V) of the present invention is significantly higher than the antitumor activity of podophyllotoxin or 4′-demethylepipodophyllotoxin.

专利号:CN-108250115-A
优先权日:2018-03-02
标 题 :Method for the coupling synthesis of aryl sulfides from tertiary amines

专利号:EP-0513863-A1
优先权日:1988-06-14
标题:Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates

专利号:EP-0513863-B1
优先权日:1988-06-14
标题:Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates

专利号:EP-0347734-A2
优先权日:1988-06-14
标 题:Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates