CAS: 504-78-9; Thiazolidine

相似化合物

14446-47-0 148312-55-4 96-53-7

上下游产品

CAS号50-00-0 甲醛 | CAS号156-57-0 半胱胺盐酸盐 | CAS号60-23-1 β-巯基乙胺 | CAS号33744-33-1 2-(methylamino)... | CAS号107-35-7 牛磺酸 | CAS号148312-53-2 N,4-dicycloprop... | CAS号89656-25-7 N-tert-butyl-1-... | CAS号52837-50-0 (9CI)-3-(氯乙酰基)-噻唑烷 | CAS号50916-00-2 1,3-thiazolidin... | CAS号51-85-4 胱胺

聚合甲醛,巯基乙胺置于phosphate Buffer体系中,用 水 作为反应溶剂,化学反应 0.5H,反应生成 四氢噻唑
参考文献:醛/半胱胺模型系统中噻唑烷形成的机理研究.
标题:醛/半胱胺模型系统中噻唑烷形成的机理研究.
摘要:提出了一种机制来阐明在醛/半胱胺模型系统中噻唑烷的形成.缓冲液可显着促进甲醛和半胱胺形成噻唑烷.磷酸盐趋于稳定形成的一级碳正离子,这可能会由于氨基氮对活性炭的攻击而导致环化反应完成.通过除去水分子,质子溶剂进一步增强了噻唑烷的形成.磷酸根离子催化的氧化还原反应导致噻唑烷通过氢化物转移转化为相应的噻唑啉.
DOI:10.1021/jf9705633

专利信息

专利号:US-12421534-B2
优先权日:2021-11-10
标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs
发明人：ALMHJELL PATRICK J; ARNOLD FRANCES H
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.

专利号:US-11161827-B2
优先权日:2019-04-05
标 题 :Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical C—H amination
发明人：Zhang xiao-xiang; Lang kai
权利人:TRUSTEES BOSTON COLLEGE; THE TRUSTEES OF BOSTON COLLEGE
摘要:In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp 3 )—H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-2024092821-A1
优先权日:2020-03-31
标题:Synthesis of oligonucleotides and related compounds
发明人：ZHONG MINGHONG; JIN YI; GALA DINESH; PRHAVC MARIJA
权利人:JANSSEN BIOPHARMA INC
摘要:Methods of synthesizing oligonucleotides via new intermediates on a cleavable support having an azidomethyl moiety are disclosed. The method comprises multiple reaction cycles, each of which comprises sequential coupling a nucleoside or oligonucleotide subunit on a cleavable support having an azidomethyl moiety and a nucleoside phosphoramidite or an oligonucleotide phosphoramidite, capping, oxidation/thiolation and deblocking; followed by orthogonal cleavage of the azidomethyl support while keeping all other protecting groups intact. The method can be used in combination with a support moiety for either solid phase or liquid phase oligo synthesis. The soluble support facilitates homogeneous reactions and efficient separations by simple precipitation. The methods also provide novel intermediates useful in the synthesis of oligonucleotide conjugates.

专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人：AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:US-10751419-B2
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters
发明人：MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E
权利人:IONIS PHARMACEUTICALS INC
摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.