专利号:WO-2013084241-A1 优先权日:2011-12-09 标题:Compounds as inhibitors of renin 发明人:THOMBARE PRAVIN S; DESAI JIGAR N 权利人:CADILA HEALTHCARE LTD; THOMBARE PRAVIN S; DESAI JIGAR N 摘要:The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to processes for preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
专利号:EP-3515880-B1 优先权日:2017-03-17 标题:Methods and compositions for synthesis of encoded libraries 发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN 权利人:HITGEN INC
专利号:US-2020149034-A1 优先权日:2017-03-17 标题:Methods and Compositions for Synthesis of Encoded Libraries
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:FR-2676225-A1 优先权日:1991-05-03 标题 :NOVEL INTERMEDIATES FOR THE SYNTHESIS OF DIALKYLENEPIPERIDINO COMPOUNDS.
专利号:FR-2676227-A1 优先权日:1991-05-03 标 题 :NOVEL INTERMEDIATES FOR THE SYNTHESIS OF DIALKYLENEPIPERIDINO COMPOUNDS.
[参考文献]: Fubo Liang, Et Al. Aurintricarboxylic Acid Blocks In Vitro And In Vivo Activity Of Yoph, An Essential Virulent Factor Of Yersinia Pestis, The Agent Of Plague. J Biol Chem. 2003 Oct 24;278(43):41734-41.
合成参考文献
摘要:L. K. Creamer, A. Fischer, B. R. Mann, J. Packer, R. B. Richards and J. Vaughan, J. Org. Chem. 26, 3148 (1961).