CAS: 706782-28-7; Pimavanserin Tartrate

N-(4-Isobutoxybenzyl)-1H-Imidazole-1-Carboxamide置于potassium Tert-Butylate体系中,用 乙醇,甲苯 作为反应溶剂,化学反应 15.0H,反应生成 匹莫范色林酒石酸盐
参考文献:匹莫范色林及其中间体的制备方法
标题:匹莫范色林及其中间体的制备方法
摘要:本发明公开了一种匹莫范色林及其中间体的制备方法,该中间体的制备方法包括下述步骤:在碱存在下,将化合物m在有机溶剂中,与化合物sm和二氧化碳反应,即得化合物a;其中,R为c1‑c4的烷基,苄基或者取代的苄基,X为cl,Br或i.本发明的制备方法操作简单,反应条件温和,收率较高,并且杂质含量低,易于纯化,能显著降低生产成本,易于工业化生产.

专利信息

专利号:US-11319288-B2
优先权日:2018-04-26
标 题:Method for the preparation of pimavanserin base
发明人：NOVO BARBARA; BONANOMI JACOPO; BERTOLOTTI MATTIA
权利人:OLON SPA
摘要:Disclosed is a process for the synthesis of pimavanserin base with a high yield and purity, which comprises: a) converting tert-butyl-N-[(4-propan-2-yloxyphenyl)methyl]carbamate (Formula (I)) to 1-(isocyanatomethyl)-4-propan-2-yloxybenzene of formula (II) b) adding N-[(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine (Formula (IV)) to the solution obtained in a) to give pimavanserin base, and c) purifying the pimavanserin base obtained in step b).

专利号:US-2007260064-A1
优先权日:2004-09-27
标题:Synthesis of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:AU-2008254238-A1
优先权日:2007-05-15
标 题:Synthesis of N-(4-fluorobenzyl)-N-(l-methylpiperidin-4-yl)-N'-(4- (2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms

专利号:CA-2692001-A1
优先权日:2007-05-15
标题:Synthesis of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms

专利号:IL-313204-A
优先权日:2021-12-15
标 题:Methods for the synthesis of complement factor d inhibitors