专利号:US-9884830-B2 优先权日:2004-05-21 标题 :Synthesis of tetracyclines and analogues thereof 发明人:MYERS ANDREW G; CHAREST MARK G; LERNER CHRISTIAN D; BRUBAKER JASON D; SIEGEL DIONICIO R 权利人:HARVARD COLLEGE 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
专利号:US-8486921-B2 优先权日:2006-04-07 标 题:Synthesis of tetracyclines and analogues thereof 发明人:MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU 权利人:MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU; HARVARD COLLEGE 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetra-cycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.
专利号:US-3891594-A 优先权日:1972-04-07 标题:Direct synthesis of composite materials 发明人:TAYLOR LYNN J 权利人:TAYLOR LYNN J 摘要:There is disclosed an in situ process for the preparation of a composite material consisting essentially of an organic polymer or copolymer having dispersed therein an inorganic oxide or mixture of oxides, said process comprising the simultaneous or sequential synthesis of the organic polymer from at least one non-polymeric organic precursor and of the inorganic oxide or oxide mixture derived from at least one inorganic-oxide precursor.
专利号:US-3817911-A 优先权日:1972-04-07 标 题 :Direct synthesis of composite materials 发明人:TAYLOR L 权利人:TAYLOR L 摘要:THERE IS DISCLOSED AN IN SITU PROCESS FOR THE PREPARATION OF A COMPOSITE MATERIAL CONSISTING ESSENTIALLY OF AN ORGANIC POLYMER OR COPOLYMER HAVING DISPERSED THEREI AN INORGANIC OXIDE OR MIXTURE OF OXIDES, SAID PROCESS COMPRISING THE SIMULTANEOUS OR SEQUENTIAL SYNTHESIS OF THE ORGANIC POLYMER FROM AT LEAST ONE NON-POLYMERIC ORGANIC PRECUROR AND OF THE INORGANIC OXIDE OR OXIDE MIXTURE DERIVED FROM AT LEAST ONE INORGANIC-OXIDE PRECURSOR.
专利号:US-3960805-A 优先权日:1974-04-19 标 题:Direct synthesis of organic polymer-inorganic oxide composites 发明人:TAYLOR LYNN JOHNSTON 权利人:TAYLOR LYNN JOHNSTON 摘要:There is disclosed an in situ process for the preparation of a composite material consisting essentially of an organic polymer or copolymer having dispersed therein an inorganic oxide or mixture of oxides, said process comprising the simultaneous or sequential synthesis of the organic polymer from at least one non-polymeric organic precursor and of the inorganic oxide or oxide mixture derived from at least one inorganic-oxide precursor.
专利号:US-3959322-A 优先权日:1960-09-22 标 题:Synthesis of 13-alkyl-gon-4-ones 发明人:HUGHES GORDON ALAN; SMITH HERCHEL 权利人:SMITH HERCHEL 摘要:The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.
[参考文献]: Aya Nagashima, Et Al. A Uniaxially Oriented Nanofibrous Cellulose Scaffold From Pellicles Produced By Gluconacetobacter Xylinus In Dissolved Oxygen Culture. Carbohydr Polym. 2016 Jan 1:135:215-24. [参考文献]: Bartosz Kazowski, Et Al. Monitoring And Preparation Of Neoagaro- And Agaro-Oligosaccharide Products By High Performance Anion Exchange Chromatography Systems. Carbohydr Polym. 2015 May 20:122:351-8. [参考文献]: Ceren Erdem, Et Al. Electrochemical Glucose Biosensor Based On Nickel Oxide Nanoparticle-Modified Carbon Paste Electrode. Artif Cells Nanomed Biotechnol. 2014 Aug;42(4):237-44. [参考文献]: Diane C Forbes, Et Al. Polymeric Nanocarriers For Sirna Delivery To Murine Macrophages. Macromol Biosci. 2014 Aug;14(8):1096-105. [参考文献]: Michael B Gluth, Et Al. Immunotargeted Photodynamic Therapy For Cholesteatoma: In Vitro Results With Anti-Egfr-Coated Indocyanine Green Nanocapsules. Otol Neurotol. 2015 Jan;36(1):76-81.
合成参考文献
摘要:Sawamura, M.; Shimizu, Y., Science of Synthesis: Knowledge Updates, (2024) 2, 214. 摘要:Ali, W.; Guin, S.; Maiti, D., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 230. 参考文献:10.1186/1752-153x-6-162 摘要:Deshmukh NI, Zachar G, Petróczi A, Székely AD, Barker J, Naughton DP. Determination of stanozolol and 3′-hydroxystanozolol in rat hair, urine and serum using liquid chromatography tandem mass spectrometry. Chemistry Central Journal. 2012 Dec;6(1). doi: 10.1186/1752-153x-6-162.