213383-01-8 = 82372-74-5 反应条件:1.1 Catalysts: Aminoacylase Solvents: Water 标题:A Convenient Preparation Of 4-Tert-Butyl-L-Phenylalanine 作者:Jiang,Jianjun; Et Al 参考文献:Synthetic Communications 日期:1998 卷标:28(16) 页码:3015-3019]
213383-01-8 = 82372-74-5 [标题:Reaction Conditions 标题:Synthesis And Angiotensin Converting Enzyme Inhibitory Activity Of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Derivatives 作者:Miyake,Akio; Et Al 参考文献:Takeda Kenkyushoho 日期:1984 卷标:43(3) 页码:53-76]
18880-00-7 + 1068-90-2 = 82372-74-5 反应条件:1.1 Reagents: Sodium Ethoxide Solvents: Ethanol1.2 -2.1 Reagents: Sodium Hydroxide Solvents: Water2.2 Reagents: Hydrochloric Acid Solvents: Water3.1 Catalysts: Aminoacylase Solvents: Water 标题:A Convenient Preparation Of 4-Tert-Butyl-L-Phenylalanine 作者:Jiang,Jianjun; Et Al 参考文献:Synthetic Communications 日期:1998 卷标:28(16) 页码:3015-3019]
19692-45-6 + 1068-90-2 = 82372-74-5 [标题:Reaction Conditions 标题:Synthesis And Angiotensin Converting Enzyme Inhibitory Activity Of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Derivatives 作者:Miyake,Akio; Et Al 参考文献:Takeda Kenkyushoho 日期:1984 卷标:43(3) 页码:53-76]
98463-12-8 = 82372-74-5 [标题:Reaction Conditions 标题:Synthesis And Angiotensin Converting Enzyme Inhibitory Activity Of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Derivatives 作者:Miyake,Akio; Et Al 参考文献:Takeda Kenkyushoho 日期:1984 卷标:43(3) 页码:53-76]
177842-12-5 = 82372-74-5 反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water1.2 Reagents: Hydrochloric Acid Solvents: Water2.1 Catalysts: Aminoacylase Solvents: Water 标题:A Convenient Preparation Of 4-Tert-Butyl-L-Phenylalanine 作者:Jiang,Jianjun; Et Al 参考文献:Synthetic Communications 日期:1998 卷标:28(16) 页码:3015-3019]
177842-12-5 = 82372-74-5 [标题:Reaction Conditions 标题:Synthesis And Angiotensin Converting Enzyme Inhibitory Activity Of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Derivatives 作者:Miyake,Akio; Et Al 参考文献:Takeda Kenkyushoho 日期:1984 卷标:43(3) 页码:53-76
在 盐酸,Lithium Hydroxide体系中,化学反应 48.0H,反应生成 L-4-叔丁基苯丙氨酸 参考文献:A Convenient Preparation Of 4-T-Butyl-L-Phenylalanine 标题:A Convenient Preparation Of 4-T-Butyl-L-Phenylalanine 摘要:A Convenient Preparation Of 4-T-Butyl-L-Phenylalanine And N-Fmoc-4-T-Butyl-L-Phenylalanine Are Described. DOI:10.1080/00397919808004880
专利号:US-7763734-B2 优先权日:2006-04-19 标题 :Synthesis, structure and use of bisoxazolidines for asymmetric catalysis and synthesis 发明人:WOLF CHRISTIAN; LIU SHUANGLONG 权利人:UNIV GEORGETOWN 摘要:One aspect of the invention relates to chiral bisoxazolidines and their use in asymmetric catalysis. The chiral bisoxazolidines are a novel class of compounds that is expected to find multiple applications, for example, in asymmetric synthesis. For example, a bisoxazolidine ligand enabled the catalytic enantioselective alkynylation and alkylation of a range of aromatic and aliphatic aldehydes, generating chiral propargylic alcohols and secondary alcohols in high yields and enantiomeric excess.
专利号:US-2025289851-A1 优先权日:2022-04-22 标 题:Cyclic peptides for delivering therapeutics 发明人:DOUGHERTY PATRICK; TOTARO KYLE A; DOMBROSKI AMANDA; GIESLER RILEY; ZHOU MING; STREETER MATTHEW; GOFFIN ALEC; QIAN ZIQING 权利人:ENTRADA THERAPEUTICS INC 摘要:The present disclosure relates to the synthesis of cyclic peptides that are able to effectively deliver cargo, e.g., a therapeutic moiety (TM), inside a cell to treat a variety of conditions and diseases.
专利号:US-2022185846-A1 优先权日:2019-03-28 标 题:Methods for synthesizing beta-homoamino acids 发明人:MANTHATI SURESH KUMAR; BHANDARI ASHOK; MASJEDIZADEH MOHAMMAD REZA 权利人:PROTAGONIST THERAPEUTICS INC 摘要:Methods of making β-homoamino acids as intermediate for synthesis of peptide monmer and dimer α4β7-antagonists are disclosed. The disclosed methods include solid phase and solution phase methods.
专利号:CN-115925790-A 优先权日:2016-03-23 标 题:Method for the synthesis of α4β7 peptide antagonists
专利号:US-2007265255-A1 优先权日:2006-04-19 标题 :Synthesis, structure and use of bisoxazolidines for asymmetric catalysis and synthesis
专利号:US-2009197800-A1 优先权日:2004-10-27 标 题:Insulin Receptor Binding Peptides with Non-Insulin Gene Activation Profiles and Uses Thereof 发明人:SCHAFFER LAUGE; FREDERIKSEN KLAUS STENSGAARD 权利人:NOVO NORDISK AS 摘要:Methods for binding insulin receptors (and typically activating one or more function of an insulin receptor) by contacting insulin receptor-presenting cells, such as cells in a subject, with an effective amount of one or more insulin receptor binding peptides, where upregulation of one or more components of the insulin receptor-associated cholesterol synthesis pathway is not desired, are provided.
参考文献:10.1016/s0968-0896(03)00153-6 摘要:Wilson D, Perlson L, Breslow R. Helical templating of oligopeptides by cyclodextrin dimers. Bioorg Med Chem. 2003 Jun 12;11(12):2649–53. doi: 10.1016/s0968-0896(03)00153-6. 参考文献:10.1007/s10858-017-0157-y 摘要:Loh CT, Adams LA, Graham B, Otting G. Genetically encoded amino acids with tert-butyl and trimethylsilyl groups for site-selective studies of proteins by NMR spectroscopy. Journal of Biomolecular NMR. 2017 Dec 02;71(4):287–93. doi: 10.1007/s10858-017-0157-y. 参考文献:10.1038/srep12974 摘要:Huang Y, Henriques ST, Wang CK, Thorstholm L, Daly NL, Kaas Q, Craik DJ. Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports. 2015 Aug 12;5(1):12974. doi: 10.1038/srep12974.