CAS: 82372-74-5; H-Phe(4-Tbu)-Oh

该化合物是一种非天然的氨基酸衍生物,其特点是在苯环在L-苯丙氨的副位置上引入了三丁基乙酸组,这种改变会增加不育量和亲脂性,使其在peptide合成和药用化学中具有价值,有助于改善结合性和代谢稳定性.Tet-丁基氨基苯组还影响符合性硬性,这对设计酶抑制剂或受体离子具有优势.其天体纯度(L-配置)能确保与生物系统兼容性.这一化合物在研究应用中特别有用,需要量制的氨基酸类,以研究结构-活性关系或优化基于的治疗方法.

结构式图片

上下游产品

CAS号6326-44-9 二乙基氨基甲肟 | CAS号19692-45-6 4-叔丁基苄氯 | CAS号18880-00-7 4-叔丁基苄溴 | CAS号177842-12-5 diethyl 4-(tert... | CAS号213383-02-9 N-芴甲氧羰基-4-叔丁基-L-苯丙氨酸

合成工艺路线路线简述

  • 213383-01-8 = 82372-74-5
    反应条件:1.1 Catalysts: Aminoacylase Solvents: Water
    标题:A Convenient Preparation Of 4-Tert-Butyl-L-Phenylalanine
    作者:Jiang,Jianjun; Et Al
    参考文献:Synthetic Communications 日期:1998 卷标:28(16) 页码:3015-3019]

    213383-01-8 = 82372-74-5 [标题:Reaction Conditions
    标题:Synthesis And Angiotensin Converting Enzyme Inhibitory Activity Of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Derivatives
    作者:Miyake,Akio; Et Al
    参考文献:Takeda Kenkyushoho 日期:1984 卷标:43(3) 页码:53-76]

    18880-00-7 + 1068-90-2 = 82372-74-5
    反应条件:1.1 Reagents: Sodium Ethoxide Solvents: Ethanol1.2 -2.1 Reagents: Sodium Hydroxide Solvents: Water2.2 Reagents: Hydrochloric Acid Solvents: Water3.1 Catalysts: Aminoacylase Solvents: Water
    标题:A Convenient Preparation Of 4-Tert-Butyl-L-Phenylalanine
    作者:Jiang,Jianjun; Et Al
    参考文献:Synthetic Communications 日期:1998 卷标:28(16) 页码:3015-3019]

    19692-45-6 + 1068-90-2 = 82372-74-5 [标题:Reaction Conditions
    标题:Synthesis And Angiotensin Converting Enzyme Inhibitory Activity Of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Derivatives
    作者:Miyake,Akio; Et Al
    参考文献:Takeda Kenkyushoho 日期:1984 卷标:43(3) 页码:53-76]

    98463-12-8 = 82372-74-5 [标题:Reaction Conditions
    标题:Synthesis And Angiotensin Converting Enzyme Inhibitory Activity Of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Derivatives
    作者:Miyake,Akio; Et Al
    参考文献:Takeda Kenkyushoho 日期:1984 卷标:43(3) 页码:53-76]

    177842-12-5 = 82372-74-5
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water1.2 Reagents: Hydrochloric Acid Solvents: Water2.1 Catalysts: Aminoacylase Solvents: Water
    标题:A Convenient Preparation Of 4-Tert-Butyl-L-Phenylalanine
    作者:Jiang,Jianjun; Et Al
    参考文献:Synthetic Communications 日期:1998 卷标:28(16) 页码:3015-3019]

    177842-12-5 = 82372-74-5 [标题:Reaction Conditions
    标题:Synthesis And Angiotensin Converting Enzyme Inhibitory Activity Of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Derivatives
    作者:Miyake,Akio; Et Al
    参考文献:Takeda Kenkyushoho 日期:1984 卷标:43(3) 页码:53-76
在 盐酸,Lithium Hydroxide体系中,化学反应 48.0H,反应生成 L-4-叔丁基苯丙氨酸
参考文献:A Convenient Preparation Of 4-T-Butyl-L-Phenylalanine
标题:A Convenient Preparation Of 4-T-Butyl-L-Phenylalanine
摘要:A Convenient Preparation Of 4-T-Butyl-L-Phenylalanine And N-Fmoc-4-T-Butyl-L-Phenylalanine Are Described.
DOI:10.1080/00397919808004880

海关参考信息

专利信息


专利号:US-7763734-B2
优先权日:2006-04-19
标题 :Synthesis, structure and use of bisoxazolidines for asymmetric catalysis and synthesis
发明人:WOLF CHRISTIAN; LIU SHUANGLONG
权利人:UNIV GEORGETOWN
摘要:One aspect of the invention relates to chiral bisoxazolidines and their use in asymmetric catalysis. The chiral bisoxazolidines are a novel class of compounds that is expected to find multiple applications, for example, in asymmetric synthesis. For example, a bisoxazolidine ligand enabled the catalytic enantioselective alkynylation and alkylation of a range of aromatic and aliphatic aldehydes, generating chiral propargylic alcohols and secondary alcohols in high yields and enantiomeric excess.

专利号:US-2025289851-A1
优先权日:2022-04-22
标 题:Cyclic peptides for delivering therapeutics
发明人:DOUGHERTY PATRICK; TOTARO KYLE A; DOMBROSKI AMANDA; GIESLER RILEY; ZHOU MING; STREETER MATTHEW; GOFFIN ALEC; QIAN ZIQING
权利人:ENTRADA THERAPEUTICS INC
摘要:The present disclosure relates to the synthesis of cyclic peptides that are able to effectively deliver cargo, e.g., a therapeutic moiety (TM), inside a cell to treat a variety of conditions and diseases.

专利号:US-2022185846-A1
优先权日:2019-03-28
标 题:Methods for synthesizing beta-homoamino acids
发明人:MANTHATI SURESH KUMAR; BHANDARI ASHOK; MASJEDIZADEH MOHAMMAD REZA
权利人:PROTAGONIST THERAPEUTICS INC
摘要:Methods of making β-homoamino acids as intermediate for synthesis of peptide monmer and dimer α4β7-antagonists are disclosed. The disclosed methods include solid phase and solution phase methods.

专利号:CN-115925790-A
优先权日:2016-03-23
标 题:Method for the synthesis of α4β7 peptide antagonists

专利号:US-2007265255-A1
优先权日:2006-04-19
标题 :Synthesis, structure and use of bisoxazolidines for asymmetric catalysis and synthesis

专利号:US-2009197800-A1
优先权日:2004-10-27
标 题:Insulin Receptor Binding Peptides with Non-Insulin Gene Activation Profiles and Uses Thereof
发明人:SCHAFFER LAUGE; FREDERIKSEN KLAUS STENSGAARD
权利人:NOVO NORDISK AS
摘要:Methods for binding insulin receptors (and typically activating one or more function of an insulin receptor) by contacting insulin receptor-presenting cells, such as cells in a subject, with an effective amount of one or more insulin receptor binding peptides, where upregulation of one or more components of the insulin receptor-associated cholesterol synthesis pathway is not desired, are provided.
南京德尔诺医药科技有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.dernopharm.com
电话: 025-86957866 13952093866👤
📞南京德尔诺医药科技有限公司 ⚠️参考联系方式

销售电话:025-86957866 13952093866
邮箱:sales@dernopharm.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
第 1 / 1 页
现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1016/s0968-0896(03)00153-6
摘要:Wilson D, Perlson L, Breslow R. Helical templating of oligopeptides by cyclodextrin dimers. Bioorg Med Chem. 2003 Jun 12;11(12):2649–53. doi: 10.1016/s0968-0896(03)00153-6.
参考文献:10.1007/s10858-017-0157-y
摘要:Loh CT, Adams LA, Graham B, Otting G. Genetically encoded amino acids with tert-butyl and trimethylsilyl groups for site-selective studies of proteins by NMR spectroscopy. Journal of Biomolecular NMR. 2017 Dec 02;71(4):287–93. doi: 10.1007/s10858-017-0157-y.
参考文献:10.1038/srep12974
摘要:Huang Y, Henriques ST, Wang CK, Thorstholm L, Daly NL, Kaas Q, Craik DJ. Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports. 2015 Aug 12;5(1):12974. doi: 10.1038/srep12974.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知