CAS: 99-53-6; 2-Methyl-4-Nitrophenol

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CAS号95-48-7 邻甲酚 | CAS号6971-38-6 6-甲基孕烯醇酮 | CAS号1426689-51-1 (E)-2,4-dinitro... | CAS号99-08-1 3-硝基甲苯 | CAS号50741-92-9 2-甲氧基-5-硝基苯甲醚 | CAS号2835-96-3 2-甲基-4-氨基苯酚 | CAS号455-88-9 2-氟-5-硝基甲苯 | CAS号99-52-5 2-甲基-4-硝基苯胺 | CAS号617-09-4 碳酸二邻甲苯酯 | CAS号636-21-5 邻甲苯胺盐酸盐 | CAS号50741-92-9 2-甲氧基-5-硝基苯甲醚 | CAS号2835-96-3 2-甲基-4-氨基苯酚 | CAS号534-52-1 4,6-二硝基邻甲酚 | CAS号136-90-3 3-甲基-4-甲氧基苯胺 | CAS号138227-68-6 1N-B°C4-(2-甲基-4... | CAS号1570-64-5 4-氯-2-甲基苯酚 | CAS号183945-52-0 3-甲基-4-三氟甲氧基苯胺 | CAS号29027-13-2 2-甲基-4,6-二硝基苯甲醚 | CAS号7477-94-3 2-甲基-4,6-二硝基苯胺 | CAS号83190-00-5 1-(difluorometh...

6-甲基孕烯醇酮置于sodium Hydroxide,双氧水体系中,用 水 作为反应溶剂,化学反应 3.0H,以61%的收率获得产物2-甲基-4-硝基苯酚
参考文献:对硝基苯酚衍生物的氧化合成
标题:对硝基苯酚衍生物的氧化合成
摘要:众所周知,对硝基苯酚及其卤素取代的衍生物具有抗真菌特性;2-氯-4-硝基苯酚 (I) [1] 的活性最高.化合物 I 进入抗真菌制剂硝芬净(spofa,捷克共和国)的组合物中.迄今为止,化合物 I 已经通过在乙酸中用游离氯氯化 4-硝基苯酚获得,并通过重量监测氯吸收 [2],或者通过在高于 4-硝基苯酚的稀盐酸中氯化 4-硝基苯酚乳液4-硝基苯酚的熔点 [3],或通过在硫酸中氯化 4-硝基苯酚 [4].正如所见,所有这些方法都涉及使用游离气态氯.在致力于创造国内抗真菌制剂的工作过程中,我们研究了使用更方便的技术获得化合物 I 的可能性.这个想法是基于这样一个事实,即一些氧化剂对盐酸的作用伴随着氯的释放.这些氧化剂中最容易获得和方便的是过氧化氢.
DOI:10.1007/bf02524600

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-2004044225-A1
优先权日:2001-06-01
标 题:Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives
发明人：KANTER JAMES; MARLOWE CHARLES; PANDEY ANJALI; MULLINS JOHN J G; SCARBOROUGH ROBERT; BUTKE GREG; JACOBSON BARRY; WALKER DEREK
摘要:Disclosed are processes for producing a (2S) or (2R) 4-oxo-chroman-2-yl acyl compounds and chroman-2-yl acyl compounds, esters or amides thereof as well as derivatives thereof. Such processes may involve chiral synthesis or achiral synthesis, preferably coupled with a resolution procedure. Such compounds, particularly (2S) or (2R) acetic acid esters, are useful intermedates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are processes for making derivatives of such substantially pure, or enhanced compositions of single (2R) or (2S) enantiomer intermediates or processes for producing final products or salts from such desired enantiomers.

专利号:WO-2025149479-A1
优先权日:2024-01-12
标题:Synthesis of modified nucleoside triphosphates
发明人：KUCHELMEISTER HANNES; PFAFFENEDER TONI; MEX MARTIN; VETH SIMON; MENKE JAN-MICHAEL
权利人:ROCHE DIAGNOSTICS GMBH
摘要:The invention relates to a new diastereoselective synthesis method for highly modified nucleoside triphosphates with two conjugable groups. The method works in liquid phase with conventional laboratory equipment as used in any chemical laboratory or production. For this, a new chiral P(V) phosphorylation reagent has been designed that allows highly efficient diastereoselective synthesis under mild conditions. Overall, a highly efficient, diastereoselective, high quality, cost-effective synthetic method of modified nucleoside triphosphates has been developed.

专利号:US-7718598-B1
优先权日:1998-09-25
标 题:Auxiliary for amide bond formation
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programmes. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganizing peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-5116987-A
优先权日:1988-12-26
标题:Method of preparing chroman derivatives, and synthesis intermediates
发明人：GARCIA GEORGES; METTEFEU DANIEL; ROUX RICHARD
权利人:SANOFI SA
摘要:The invention describes a method of synthesizing a compound of the formula ##STR1## in which X=O or NR, n Z=an electron-attracting group, n R=H, CN or NO 2 , n R 1 +R 2 +N--Câ•?X=a 5-membered or 6-membered heterocycle, and n R 3 =H, R 4 =OH or R 3 +R 4 =a bond, n said method involving intermediates of the formula ##STR2## in which R 5 =H, Br or N(R 1 )CXR 2 . This method of synthesis does not involve the epoxide derivative of the chroman. n The novel compounds of formula (IX) form a further subject of the invention.

专利号:WO-0018790-A1
优先权日:1998-09-25
标 题 :Synthesis of cyclic peptides