CAS: 101-59-7; 4-((4-Nitrophenyl)Thio)Aniline

该化合物是一种有机化合物,其特征是附于苯乙烯环的有矿和硝基化合物.该化合物具有硫醚联系,硫磺原子将4-硝基苯组与厌食动物联系起来.该物质一般是固体,并可能因硝基替代而呈现黄色颜色.硝基化合物的存在会助长其电子提取特性,影响其再活性和溶解溶性.该化合物经常用于有机合成,并作为染料和药品生产的中间体.其化学行为可能受到诸如pH和其他功能组的存在等因素的影响.在处理该化合物时,应当采取安全防范措施,因为它可能构成健康风险,包括潜在的毒性和环境危害.适当的储存和处置方法对于减轻与其使用有关的任何风险至关重要.

结构式图片

相似化合物

139-65-1 952-97-6 1223-31-0

欧盟法规

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上下游产品

di(p-nitrophenyl) disulfide bis(4-nitrophenyl)sulfide 4-nitrobenzensulfenic acid anilide 4-chlorobenzonitrile N-[4-(4-nitro-phenylsulfanyl)-phenyl]-succinamic acidN-[4-(4-nitro-phenylsulfanyl)-phenyl]-succinamic acid [4-(4-nitro-phenylsulfanyl)-phenyl]-urea 4-methyl-valeric acid-[4-(4-nitro-phenylsulfanyl)-anilide] benzthiazol2-Amino-6-(p-nitrophenyl)thiobenzthiazol

合成工艺路线路线简述

    4,4'-二硝基二苯二硫醚置于氨体系中,化学反应生成4-氨基-4'-硝基二苯硫醚
    参考文献:Fromm; Wittmann,Chemische Berichte,1908,Vol. 41,P. 2264
    标题:Fromm; Wittmann,Chemische Berichte,1908,Vol. 41,P. 2264

    专利信息


    专利号:US-9845289-B2
    优先权日:2014-08-01
    标题 :Process for the synthesis of Dapsone and its intermediates
    发明人:BARATELLA MARCO; CASTALDI GRAZIANO; CASTALDI MARTA; GABOARDI MAURO; PALLANZA GIUSEPPE
    权利人:SEEGPHARM SA
    摘要:A process for the synthesis of Dapsone and intermediates thereof are described.

    专利号:US-7531694-B2
    优先权日:2004-07-07
    标题:Process for synthesis of 4-4′-diamino-diphenyl-sulfone
    发明人:VILLA MARCO; DE FAVERI CARLA; ZANOTTI RICCARDO; CIARDELLA FRANCESCO; BORIN FABRIZIO
    权利人:LUNDBECK PHARMACEUTICALS ITALY
    摘要:A new process for the preparation and purification of 4-4′-diamino-diphenyl-sulfone (dapsone) is described. The process described is a three step process comprising a condensation reaction with the synthesis of a thioether intermediate and then steps of oxidation and reduction in suitable conditions in order to obtain a product with good yield and purity.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-2008293970-A1
    优先权日:2004-07-07
    标 题:Process for Synthesis of 4-4'-Diamino-Diphenyl-Sulfone

    专利号:WO-2006002690-A1
    优先权日:2004-07-07
    标 题 :Process for synthesis of 4-4'-diamino-diphenyl-sulfone
    杭州汤捷姆化工贸易有限公司
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    合成参考文献


    摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/S_schafer851.pdf
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