CAS: 17347-61-4; 2,2-Dimethylsuccinicanhydride

该化合物是一种循环死箱化合物,其特点是五人组成的内酯环状结构,该化学品在环开聚合聚合物中作为单体具有高度反应性,因此具有价值,可合成具有定制特性的生物降解聚酯,其对称结构和3,3-二甲基替代会增强热稳定性和影响聚合物晶体性,该化合物在生物医学应用中特别有用,如受控药物运载系统和可转质材料,因为其水解降解成可生物兼容的副产品,其纯度和明确界定的分子结构确保聚合工艺的一贯性,对材料特性提供精确的控制.

结构式图片

相似化合物

35046-68-5 4100-80-5 50598-33-9

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

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合成工艺路线路线简述

    2,2-二甲基琥珀酸置于tetrabutylammonium Rhodanide体系中,用 乙腈 用作溶剂,以66%的收率获得2,2-二甲基琥珀酸酐
    参考文献:二元酸电化学脱水成环酸酐
    标题:二元酸电化学脱水成环酸酐
    摘要:提出了二羧酸与其环状酸酐的电化学脱水反应.电化学产生的酸酐可直接用于酰胺化反应.通过18 O 同位素标记研究了反应机理,揭示了电解过程中硫酸盐的形成.
    Doi:10.1002/chem.202400403

    海关参考信息

    专利信息


    专利号:US-8138272-B2
    优先权日:2006-05-22
    标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
    发明人:KONRADI ANDREI W; SMITH JENIFER L
    权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
    摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

    专利号:WO-2025124564-A1
    优先权日:2023-12-15
    标题:Polyester synthesis based on aspartic acid modification
    发明人:ZHANG KECHUN; CHEN XI; LEI TENGFEI; LIU SHENGYANG
    权利人:MINT BIOTECHNOLOGIES CO LTD
    摘要:Provided in the present invention is polyester synthesis based on aspartic acid modification. A monomer of a unique structure of an imide ring is obtained based on aspartic acid and a dibasic acid likely to be cyclized, the monomer is based on the aspartic acid, can be derived from biomass, is low in cost and renewable, meets the requirement of sustainable development, and the unique structure of the monomer can regulate and control various properties of polyester materials, such as the mechanics, temperature resistance, hydrophilicity and hydrophobicity, and crystallization.

    专利号:US-10793557-B2
    优先权日:2018-04-03
    标题 :Sting agonist compounds
    发明人:ALTMAN MICHAEL D; CASH BRANDON D; CHILDERS MATTHEW LLOYD; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW MARC; HENDERSON TIMOTHY J; JEWELL JAMES P; LARSEN MATTHEW A; LIM JONGWON; LU MIN; OTTE RYAN D; TROTTER BENJAMIN WESLEY
    权利人:MERCK SHARP & DOHME
    摘要:Compounds of general formula (I), of general formula (II), of general formula (III), of general formula (IV), of general formula (V), of general formula (VI), and their pharmaceutically acceptable salts, wherein all variables are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

    专利号:CN-101365674-A
    优先权日:2005-07-21
    标题:Modulators of interleukin-1 and tumor necrosis factor alpha, synthesis of the modulators and methods of using the modulators

    专利号:US-8338565-B2
    优先权日:2008-08-20
    标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
    发明人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
    权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
    摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

    专利号:JP-2009505954-A
    优先权日:2005-07-21
    标题 :Interleukin-1 and tumor necrosis factor-a modifier, synthesis of such modifiers and methods of using such modifiers
    南京阿托化工科技有限公司
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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Shi, Y.; Cole-Hamilton, D. J.; Kamer, P. C. J., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 221.
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