CAS: 1918-77-0; 2-(Thiophen-2-yl)Acetic Acid

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CAS号5371-94-8 2-methoxy-2-thi... | CAS号35320-27-5 2,2,2-trichloro... | CAS号98-03-3 2-噻吩甲醛 | CAS号75-25-2 三溴甲烷 | CAS号75-08-1 乙硫醇 | CAS号201230-82-2 carbon monoxide | CAS号636-72-6 2-噻吩甲醇 | CAS号91668-56-3 2-Propenenitril... | CAS号88-15-3 2-乙酰基噻吩 | CAS号104314-04-7 3-(4-氟苯基)-2-噻吩-2-丙烯酸 | CAS号39098-97-0 2-噻吩乙酰氯 | CAS号92206-54-7 罗替戈汀 | CAS号4461-29-4 噻酚-2-乙酰胺 | CAS号50-59-9 头孢噻啶 | CAS号194232-37-6 1-diazonio-3-th... | CAS号99755-59-6 罗替高汀 | CAS号554-14-3 2-甲基噻吩 | CAS号5402-55-1 2-噻吩乙醇 | CAS号15022-15-8 噻吩-2-乙醛

2,2,2-三氯-1-(噻吩-2-基)-乙醇置于sodium Tetrahydroborate,二苯基二硒醚,Sodium Hydroxide体系中,用 乙醇 用作溶剂,以94%的收率获得2-噻吩乙酸
参考文献:醛的一般和实际转化为均聚的羧酸.
标题:醛的一般和实际转化为均聚的羧酸.
摘要:在碱性条件下,醛与三氯甲基甲烷,然后与硼氢化钠或苯基硒基(三乙基)硼酸钠反应,可以高收率得到同系羧酸.该操作简单的过程为其他认证协议提供了一种实用,有效的替代方法.该方法与敏感的醛兼容,包括烯醛和可烯化的醛.它还提供了方便的获取α-单十二烷基羧酸的途径.
Doi:10.1021/ol8016484

专利信息

专利号:US-7317129-B2
优先权日:2002-06-07
标 题:Chemical synthesis of reagents for peptide coupling
发明人：RAINES RONALD T; KIESSLING LAURA L; NILSSON BRADLEY L; HE YI; SOELLNER MATTHEW B; HINKLIN RONALD J
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.

专利号:US-10669292-B2
优先权日:2014-05-05
标 题 :Synthesis of boronate salts and uses thereof
发明人：HECKER SCOTT; BOYER SERGE
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

专利号:US-4713479-A
优先权日:1986-11-28
标题 :Synthesis of high-purity dialkyl 2-vinylcyclopropane-1,1-dicarboxylate
发明人：CLARK JR CLARENCE E; FAYTER JR RICHARD G
权利人:NAT DISTILLERS CHEM CORP
摘要:This invention relates to a two-step synthesis of high purity dialkyl 2-vinyl-cyclopropane-1,1-dicarboxylate in which a mixture of trans- and cis-1,4-dihalobutene-2 is first isomerized to essentially trans-1,4-dihalobutene-2 followed immediately by cyclocondensing the resultant trans-1,4-dihalobutene-2 with a malonic ester in the presence of an alcoholic solution of a metallic alkoxide.

专利号:US-7619116-B2
优先权日:2003-12-17
标 题:Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation
发明人：DAMBRIN VALERY; LENOIR JEAN-YVES; SCHNEIDER JEAN-MARIE; GUILLAMOT GERARD; FOLLET MICHEL; BECKER ABRAM
权利人:PRODUCTS CHIMIQUES AUXILIAIRES
摘要:A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.

专利号:US-2010204449-A1
优先权日:2007-09-04
标 题 :Methods and intermediates for chemical synthesis of polypeptides and proteins
发明人：DONG ZHENG XIN; KIM SUN H
权利人:DONG ZHENG XIN; KIM SUN H
摘要:The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal β-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-amino-thioester intermediate that spontaneously rearranges to form an amide bond. The invention also relates to methods of synthesizing β-methyl-cysteine (SEQ ID NO: 1) and its protected forms. Furthermore, the invention relates to converting a β-methyl-thiazolidine residue to a β-methyl-cysteine (SEQ ID NO: 1) residue of polypeptides and proteins.

专利号:US-5268271-A
优先权日:1989-12-12
标题 :Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase
发明人：GUISAN SEIJAS JOSE M; FERNANDEZ LAFUENTE ROBERTO; ALVARO CAMPOS GREGORIO; BLANCO MARTIN ROSA M; MOLINA ROSELL CRISTINA
权利人:CONSEJO SUPERIOR INVESTIGACION
摘要:Synthesis of semi-synthetic monobactamic or β-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a thermodynamically controlled strategy in monophase water/cosolvent organic apolar systems, wherein the concentration of the cosolvent varies between 30% and 90%, the temperature between -10° C. and 50° C., the pH between 4.5 and 8.5, with concentrations of the antibiotic nucleus between 0.5 an 875 mM and acyl donor between 0.2 mM and 1M, with a relationship antibiotic ring/activated or free acyl donor, using a buffer between 0 and 1M. Application to the pharmaceutical industry.