13939-06-5 + 55304-75-1 = 3796-23-4 + 80194-69-0 反应条件:1.1 Solvents: Acetonitrile,Water; 16 H,Ph 9.5,Rt -> 45 °C1.2 Reagents: Sodium Chloride Solvents: Ethanol; Overnight,-20 °C1.3 Reagents: Cesium Hydroxide Catalysts: Palladate(1-),[2′-(Amino-Kn)[1,1′-Biphenyl]-2-Yl-Kc]Chloro[2′-(Dicyclohexylphos... Solvents: 1-Methoxy-2-Propanol,Water; 15 H,80 °C 标题:Palladium-Catalyzed Hydroxycarbonylation Of (Hetero)Aryl Halides For Dna-Encoded Chemical Library Synthesis 作者:Li,Jian-Yuan; Et Al 参考文献:Bioconjugate Chemistry 日期:2019 卷标:30(8) 页码:2209-2215
烟酸置于f6Mo体系中,化学反应 40.0H,以69%的收率获得3-三氟甲基吡啶 参考文献:Shustov,L. D.; Nikolenko,L. N.; Senchenkova,T. M.,Journal Of General Chemistry Of The Ussr,1983,Vol. 53,# 1,P. 85-86 标题:Shustov,L. D.; Nikolenko,L. N.; Senchenkova,T. M.,Journal Of General Chemistry Of The Ussr,1983,Vol. 53,# 1,P. 85-86
专利号:US-10011567-B1 优先权日:2017-03-09 标题 :Method for the synthesis of acrylate derivatives 发明人:WANG MINGWEN; ZHANG YUE 权利人:INNOSCI LLC 摘要:The present invention provides an improved synthesis of a salt of acrylate derivatives. The synthesis generally includes the preparation of an ester or an amide containing a leaving group followed by the formation of a salt.
专利号:WO-2025122636-A1 优先权日:2023-12-04 标题:Method for the synthesis of acrylate derivatives 发明人:CAICEDO-CARVAJAL CARLOS; KATZ JORDAN; CHOI SEAN 权利人:ORTHOBOND CORP 摘要:The disclosure relates to the synthesis of quaternary salts of various acrylates in high yield and high purity.
专利号:WO-2011092618-A1 优先权日:2010-01-28 标题 :Method for the preparation of fluazinam 发明人:PASTORIO ANDREA; MORA CLAUDIA 权利人:FINCHIMICA SRL; PASTORIO ANDREA; MORA CLAUDIA 摘要:A method for the synthesis of 3-chloro, N- (3-chloro-5- trifluoromethyl-2-pyridyl), α, α, α-trif luoro, 2,6-dinitro- p-toluidine (Fluazinam) comprises an amination reaction of a pyridine, to obtain 2-amino, 3-chloro, 5- trif luoromethylpyridine, the addition of a strong base to the 2-amino, 3-chloro, 5-trif luoromethylpyridine, and a formation reaction of Fluazinam by coupling of the 2- amino-3-chloro-5-trif luoromethylpyridine with the 2,4- dichloro, 3,5-dinitro, benzotrif luoride. The amination reaction is conducted with anhydrous ammonia in an organic solvent. Furthermore, the coupling reaction as above takes place directly in the solution of Pyridine 2 coming from the amination step.
专利号:US-7812161-B2 优先权日:2007-03-05 标 题 :Synthesis of GlyT-1 inhibitors 发明人:PFLEGER CHRISTOPHE; WALDMEIER PIUS; WANG SHAONING 权利人:HOFFMANN LA ROCHE 摘要:The present invention relates to a process for preparation of a compound of formula I n nwhereinn Het, R 1 , R 2 , R 3 , and n are as defined herein and pharmaceutically acceptable acid addition salts thereof, which comprises reacting a compound of formula 21 with a compound of formula 8 to obtain a compound of formula 11 and coupling the compound of formula 11 in the presence of a coupling reagent or the corresponding acid halogenide with a compound of formula 15 to obtain a compound of formula I.
专利号:US-10995078-B2 优先权日:2013-03-13 标 题:Compounds and compositions for inhibition of FASN 发明人:BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J 权利人:FORMA THERAPEUTICS INC 摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
专利号:US-12336981-B2 优先权日:2010-09-03 标题 :Compounds and compositions for the inhibition of NAMPT 发明人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG 权利人:VALO HEALTH INC; GENENTECH INC 摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
[参考文献]: B A Gaskell, Et Al. Olfactory And Hepatic Changes Following A Single Inhalation Exposure Of 3-Trifluoromethyl Pyridine In Rats: Concentration And Temporal Aspects. Toxicology. 1990 May 14;62(1):35-51. [参考文献]: B A Gaskell, Et Al. Olfactory And Hepatic Changes Following Inhalation Of 3-Trifluoromethyl Pyridine In Rats. Toxicology. 1988 Jun;50(1):57-68.
合成参考文献
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