CAS: 4036-30-0; (S)-2-Phenylsuccinic Acid

上下游产品

2-phenylsuccinic acid 4-hydroxy-3-phenylbutyro-1,4-lactone 2,3-dideoxy-3C-phenyl-D-manno-heptono-1,4-lactone (S)-methyl-3-(6-((tert-butyldimethylsilyloxy)methyl)-3-hydroxy-4-oxo-4H-pyran-2-yl)-3-phenylpropanoate (S)-(+)-2-cyclohexylbutanedioic acid (S)-(+)-3-phenyldihydrofuran-2,5-dione (2S)-2-phenylbutane-1,4-diol S)-N-methyl-2-phenyl-succinamic acid(S)-N-methyl-2-phenyl-succinamic acid

2,3-Dideoxy-3C-Phenyl-D-Manno-Heptono-1,4-Lactone置于chromium(Vi) Oxide,Sodium Hydroxide,Sodium Periodate,Potassium Dihydrogenphosphate,硫酸体系中,用 水,丙酮 作为反应溶剂,化学反应 1.5H,反应生成 (S)-(+)-苯基丁二酸
参考文献:不对称合成.第6部分.铜盐促进格氏试剂添加到2,3-二脱氧-4,5 :6,7-二-O-异亚丙基-D-阿拉伯糖-反庚二烯酸乙酯中,随后形成旋光的2-烷基(或芳基)丁烷-1,4-二酸和丁-1,4-内酯
标题:不对称合成.第6部分.铜盐促进格氏试剂添加到2,3-二脱氧-4,5 :6,7-二-O-异亚丙基-D-阿拉伯糖-反庚二烯酸乙酯中,随后形成旋光的2-烷基(或芳基)丁烷-1,4-二酸和丁-1,4-内酯
摘要:铜盐促进芳基和叔丁基格氏试剂的1,4-增补乙基-2,3-二脱氧-4,5-:6,7-二-ö异亚丙基d-阿拉伯-反式-庚-2-Enonate是高度立体收益产品与d-甘露-构型.相比之下异丙基和乙基格氏试剂,得到的产品主要发生与d-葡萄糖-构型.环己基溴化不立体选择性反应,但给出了一个55:在45混合物d-葡糖-和d-甘露-异构体.碳水化合物分子的受控降解提供了2-芳基(烷基)丁烷-1,4-二酸和3-芳基(烷基)-丁酰基-1,4-内酯.这些产物的对映体纯度是通过参考已知产物或通过使用光学活性NMR位移试剂来确定的.
DOI:10.1039/p19830002629

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-8309742-B2
优先权日:2007-05-09
标题 :Use of the PigD protein for catalyzing 1,4-additions of 2-oxoalkanoates to α, β-unsaturated ketones
发明人：MUELLER MICHAEL; DRESEN CAROLA; RICHTER MICHAEL
权利人:MUELLER MICHAEL; DRESEN CAROLA; RICHTER MICHAEL; UNIV ALBERT LUDWIGS FREIBURG
摘要:The present invention relates to the preparation of compounds of the general formula II which can be obtained by 1,4 addition of 2-oxoalkanoates or 2-oxocarboxylic acids onto the appropriate ketones. The present invention also relates to the use of the PigD protein for catalysis of 1,4 additions of 2-oxoalkanoates/-carboxylic acids, for example pyruvate/pyruvic acid or 2-oxobutyrate/2-oxobutyric acid, onto aliphatic, aromatic and heterocyclic α,β-unsaturated ketones. The 1,4 additions are effected here with CO2 elimination. The use of the PigD protein as a catalyst in the aforementioned 1,4 additions enables the synthesis of addition products with stereoactive centers these addition products being preparable with an enantiomeric excess of more than 80% ee. The aliphatic, aromatic and heterocyclic α,β-unsaturated ketones which are suitable for the process are represented by the general formula I:

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-11299491-B2
优先权日:2018-11-16
标 题:Synthesis of key intermediate of KRAS G12C inhibitor compound

专利号:US-2025206735-A1
优先权日:2018-11-16
标题:Synthesis of key intermediate of kras g12c inhibitor compound

专利号:US-12391689-B2
优先权日:2018-11-16
标题 :Synthesis of key intermediate of KRAS G12C inhibitor compound