CAS: 5392-10-9; 2-Bromo-4,5-Dimethoxybenzaldehyde

上下游产品

CAS号120-14-9 藜芦醛； 3,4-二甲氧基苯甲醛 | CAS号121-33-5 香草醛 | CAS号54370-00-2 2-溴-4,5-二甲氧基苄醇 | CAS号14140-15-9 4-羟基苯乙基溴 | CAS号60632-40-8 6-溴香兰素 | CAS号77-78-1 硫酸二甲酯 | CAS号63190-11-4 (3,4-dimethoxy-... | CAS号20357-25-9 6-硝基藜芦醛 | CAS号74-88-4 碘甲烷 | CAS号106824-48-0 4,5-dimethoxy-2... | CAS号110451-87-1 (2-iodo-4,5-dim... | CAS号60632-40-8 6-溴香兰素 | CAS号54370-00-2 2-溴-4,5-二甲氧基苄醇 | CAS号14382-91-3 2-羟基-4,5-二甲氧基苯甲醛 | CAS号120-14-9 藜芦醛； 3,4-二甲氧基苯甲醛 | CAS号151539-52-5 2-溴-4,5-二甲氧基肉桂酸 | CAS号29237-14-7 2-(2-formyl-4,5... | CAS号25379-17-3 2,3-dimethoxy-1... | CAS号25001-57-4 justicidin A

3,4-二甲氧基苯甲醛置于溴体系中,用 溶剂黄146 作为反应溶剂,以78%的收率获得产物6-溴藜芦醛
参考文献:金催化脱氧 Nazarov 环化 2,4-Dien-1-Als 立体选择性合成高度取代的环戊烯
标题:金催化脱氧 Nazarov 环化 2,4-Dien-1-Als 立体选择性合成高度取代的环戊烯
摘要:用烯丙基硅烷和 Pph(3)Ausbf(6) (3 Mol %) 处理 2,4-Dien-1-Als 导致形成 1,4-双(烯丙基)环戊烯基产物;根据催化剂筛选,这种金催化剂优于常用的路易斯酸.这种金催化的脱氧环化反应与各种基于氧,胺,硫,氢和碳的亲核试剂相容.2,4-Dien-1-Als 与富电子烯烃和芳烃的多种环化证明了这种新催化的价值,提供了对复杂环戊烯骨架的轻松访问.环化产物的结构分析揭示了 Nazarov 环化参与的证据.这种脱氧环化可扩展为串联的分子内环化/亲核加成级联,得到具有受控立体化学的多环碳或氧杂环化合物.这种新的金催化应用于巴西烷家族天然化合物的短程合成,包括巴西烷,O-三甲基巴西烷和 O-四甲基巴西烷.
DOI:10.1021/ja806415T

专利信息

专利号:US-8779123-B2
优先权日:2012-12-06
标题:Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8779121-B2
优先权日:2012-10-12
标题:Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8957230-B2
优先权日:2011-06-30
标 题 :Synthesis of cleistanthin A and derivatives thereof
发明人：MULIK NILESH SHRIDHAR; PANGHAVANE KAILASH DATTATRAYA
权利人:MULIK NILESH SHRIDHAR; PANGHAVANE KAILASH DATTATRAYA
摘要:The present invention provides a method for preparing Cleistanthin A, a diphyllin glycoside, derivatives thereof and intermediates thereto. In particular the present invention provides in one of the aspect a method for synthesis of compound of formula D a key intermediate of diphyllin, which can be carried out in a shorter duration and at an ordinary temperature.

专利号:US-9505733-B2
优先权日:2011-11-18
标题:Single step enantioselective process for the preparation of 3-substituted chiral phthalides
发明人：REDDY REKULA SANTOSH; NAGA CHITHANYA KIRAN INDUKURU; ARUMUGAM SUDALAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses single step, highly enantioselective catalytic oxidative cyclization process for the synthesis of 3-substituted chiral phthalides. In particular, the invention discloses asymmetric synthesis of chiral phthalides via synergetic nitrile accelerated oxidative cyclization of o-cyano substituted aryl alkenes in high yield and enantiomeric excess (ee) in short reaction time. Also, disclosed herein is “one-potâ€? asymmetric synthesis of biologically important natural compounds having 3-substituted chiral phthalide structural framework in the molecule.

专利号:US-9650355-B2
优先权日:2013-01-31
标 题 :Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure
发明人：HAM JUNGYEOB; KIM TAE JUNG; KWON HAK CHEOL; JEONG KYU HYUK; SONG JUNGHO; CHUNG BONG CHUL
权利人:KOREA INST SCI & TECH
摘要:The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

专利号:US-5175302-A
优先权日:1987-07-13
标 题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.