CAS: 5508-58-7; (S,E)-4-Hydroxy-3-(2-((1R,4As,5R,6R,8As)-6-Hydroxy-5-(Hydroxymethyl)-5,8A-Dimethyl-2-Methylenedecahydronaphthalen-1-yl)Ethylidene)Dihydrofuran-2(3H)-One

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CAS号2131-43-3 1,2,5,6-四甲基萘

专利信息

专利号:WO-2022043461-A1
优先权日:2020-08-27
标 题 :Production of oxygenated diterpenoid compounds
发明人：ANDERSEN-RANBERG JOHAN; HANSEN NIKOLAJ; FORMAN VICTOR
权利人:UNIV COPENHAGEN
摘要:Disclosed is a method for production of oxygenated diterpenoid compounds, such as triptophenolide, triptonide and triptolide, by inserting genes encoding particular cytochrome P450 enzymes and expressing the genes in selected host cells for synthesis of the compounds. Further disclosed are particular cytochrome P450 enzymes suitable for this synthesis.

专利号:US-8734846-B2
优先权日:2008-06-16
标 题 :Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
发明人：ALI MIR M; HRKACH JEFF; ZALE STEPHEN E; ALVAREZ DE CIENFUEGOS LUIS
权利人:BIND BIOSCIENCES INC
摘要:This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization fromâ€? approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling toâ€? that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonalâ€? chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:US-8084495-B2
优先权日:2004-02-03
标题 :Composition of labdane diterpenes extracted from andrographis paniculata, useful for the treatment of autoimmune diseases, and alzheimer disease by activation for PPR-gamma receptors
发明人：HANCKE OROZCO JUAN LUIS; BURGOS AGUILERA RAFAEL AGUSTIN
权利人:HANCKE OROZCO JUAN LUIS; BURGOS AGUILERA RAFAEL AGUSTIN; HERBAL POWERS CORP
摘要:The diterpenic labdane 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,ha-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-dihydro-4-hydroxy-2(3h)-furanone, chemically diagrammed as n ninhibits the synthesis of pro-inflammatory cytokines, activates the PPAR-gamma receptor and diminishes nuclear factor kappa B.n n The compound is useful to treat auto-immune diseases, for organ and tissue transplantation, and to treat immunodeficiency (e.g., AIDS).

专利号:US-3600425-A
优先权日:1963-09-13
标 题:Synthesis of steroids
发明人：FRIED JOSEF
权利人:SQUIBB & SONS INC
摘要:THIS INVENTION RELATES TO NOVEL COMPOUNDS HAVING THE FORMULAE 1-BOOC-,3A,8A,10A-TRI-H3C-,9-R,9-R''-1,2,3,3A,3B,4,6,7,8, 8A,8B,9,10,10A-TETRADECAHYDRODICYCLOPENTA(A,F)NAPHTHA- LEN-6-ONE , 1-BOOC-,3A,8A,10A-TRI-H3C-,1,2,3,3A,3B,4,6,7 ,8,8A,10,10A-DODECAHYDRODICYCLOPENTA(A,F)NAPHTHALEN-6- ONE, 1-BOOC-,3A,8A,10A-TRI-H3C-,9-R,9-R''-1,2,3,3A,3B,4, 6,7,8,8A,8B,9,10,10A-TETRADECAHYDRODICYCLOPENTA(A,F)- NAPHTHALENE-3,6-DIONE AND 1-BOOC-,3A,8A,10A-TRI-H3C-, 1,2,3,3A,3B,4,6,7,8,8A,10,10A-DODECAHYDRODICYCLOPENTA(A, F)NAPHTHALENE-3,6-DIONE WHEREIN B IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL; R IS HYDROGEN; R1 IS HYDROXY; AND TOGETHER R AND R1 IS OXO(O=). THESE COMPOUNDS ARE INTERMEDIATES FOR STEROIDS POSSESSING ANTI-ANDROGENIC ACTIVITY.