CAS: 564483-18-7; 2-(Dicyclohexylphosphino)-2',4',6'-Tri-I-Propyl-1,1'-Biphenyl

上下游产品

2-bromo-1-chlorobenzene 2,4,6-triisopropyl-1-bromobenzene chlorodicyclohexylphosphane dicyclohexylbromophosphinetert-butyl 2-(benzamido)-4-(1H-indol-1-yl)benzoate tert-butyl 2-(benzamido)-4-(2-nitroanilino)benzoate tert-butyl 2-(benzamido)-4-(1H-pyrrol-1-yl)benzoate tert-butyl 2-(benzamido)-4-(4-phenylpiperidin-1-yl)benzoate

Dicyclohexyl(2',4',6'-Triisopropylbiphenyl-2-yl)Phosphine Oxide置于草酰氯,四甲基乙二胺,Sodium Iodide体系中,用 乙腈 作为反应溶剂,以79 %的收率获得产物2-二环己基磷-2,4,6-三异丙基联苯
参考文献:叔胺介导的氧化膦还原为膦
标题:叔胺介导的氧化膦还原为膦
摘要:在不使用高活性还原剂的情况下还原氧化膦代表了一种更安全,更可持续的有机磷化合物回收解决方案.在此,我们公开了通过不寻常的分子间氢化物转移进行的n,N,N ',N'-四甲基乙二胺(tmeda)介导的还原.机理研究表明tmeda充当氢化物供体,而p(V)卤代鏻盐充当氢化物受体.该方法提供了一种可扩展且高效的方案,可在温和条件下减少氧化膦.
DOI:10.1021/acs.Orglett.3C01690

专利信息

专利号:US-8283476-B2
优先权日:2007-06-26
标 题:Transition metal catalyzed synthesis of 2H-indazoles
发明人：HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS
权利人:HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional 2H-indazoles or 2H-azaindazoles of the formula (I) from 2-halo-phenylacetylenes or (2-sulfonato)phenylacetylenes and monosubstituted hydrazines.

专利号:EP-4186890-A1
优先权日:2021-11-29
标题 :Preparation of n-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide for the synthesis of tirbanibulin
发明人：ARE CELESTE; BALLETTE ROBERTO; DOBARRO RODRÃ GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:The present invention relates to a process for the preparation of N-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide, which is a suitable intermediate for the synthesis of tirbanibulin or a pharmaceutically acceptable salt thereof, as well as to a process for the preparation of tirbanibulin or a pharmaceutically acceptable salt thereof using said N-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide intermediate.

专利号:WO-2024260325-A1
优先权日:2023-06-19
标题 :Synthesis of macrocyclic compound and medical use of macrocyclic compound
发明人：LU HONGFU; DING XIAO; REN FENG
权利人:INSILICO MEDICINE IP LTD
摘要:Provided in the present invention are the synthesis of a macrocyclic compound and the medical use of the macrocyclic compound. Specifically, provided in the present invention are a compound as show in formula (II), a stereoisomer thereof or a pharmaceutically acceptable salt thereof, which can be used as a CDK7 inhibitor.

专利号:US-12312325-B2
优先权日:2022-03-01
标 题:Methods and compounds useful in the synthesis of an AAK1 inhibitor
发明人：CHEN TAO; WU WENXUE; YAN JUN; ZENG XIANGLU; ZHAO MATTHEW MANGZHU
权利人:LEXICON PHARMACEUTICALS INC
摘要:Methods for the synthesis of (S)-1-((2′,6-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine and salts thereof are disclosed, as well as compounds useful therein.

专利号:US-12240835-B2
优先权日:2018-09-18
标题:Substituted benzamides as intermediates in the synthesis of inhibitors of tyrosine kinase enzymatic activity
发明人：ROMERO F ANTHONY; KIRSCHBERG THORSTEN A; HALCOMB RANDALL; XU YINGZI
权利人:TERNS PHARMACEUTICALS INC
摘要:Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease. Intermediates such as compounds of Formula (S23), which are useful in the synthesis of compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, are also provided.

专利号:US-8026375-B2
优先权日:2007-04-13
标题:Transition metal catalyzed synthesis of N-aminoindoles
发明人：HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; RKYEK OMAR; URMANN MATTHIAS; ALONSO JORGE
权利人:SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; R6; A1; A2; A3; A4, Q, T and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional N-aminoindole or N-amino-azaindoles of the formula I from 2-halo-phenylacetylenes or (2-sulfonato)phenyl-acetylenes and N,N-disubstituted hydrazines, useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.