CAS: 936329-94-1; Potassium Trifluoro(Morpholinomethyl)Borate

相似化合物

4497-04-5 1268340-94-8 89583-06-2

C5H10Nb(Oh)2置于potassium Hydrogen Difluoride体系中,用 甲醇 作为反应溶剂,化学反应 0.33H,反应生成 (吗啉-4-基)甲基三氟硼酸钾
参考文献:Fluoroboron Compound,Aminomethylating Agent For Aromatic Ring Made Of The Same,And Production Method Of Compound Containing Aminomethyl Aromatic Ring Using Aminomethylating Agent
标题:Fluoroboron Compound,Aminomethylating Agent For Aromatic Ring Made Of The Same,And Production Method Of Compound Containing Aminomethyl Aromatic Ring Using Aminomethylating Agent
摘要:本发明涉及一种含有一级,二级或三级氨甲基芳环的化合物的生产方法,包括以下步骤:使用由式(i)表示的氟硼化合物或其二聚体或溶剂化物作为芳环的氨甲基化试剂;在金属催化剂(如钯化合物)的存在下,将氨甲基化试剂与能够与其反应的含芳环化合物反应,从而进行芳环的直接氨甲基化.式(i)如下:Ra(Rb)N-ch2-bf3M (I)

专利信息

专利号:US-9051289-B2
优先权日:2013-09-26
标 题 :Process and intermediates for preparing GPR40 agonists
发明人：DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN
权利人:DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of formula I n nwherein R S denotes F or CF 3 , R a denotes H or C 1-4 -alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.