CAS: 951695-85-5; Fmoc-Lys(Me,Boc)-Oh

• 英文名称Fmoc-Lys(Me,Boc)-Oh
• 中文名称N'-叔丁氧羰基-N-芴甲氧羰基-N'-甲基-L-赖氨酸
• IUPAC名称N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-N6-methyl-L-lysine
• 其它别名N~6~-(Tert-Butoxycarbonyl)-N~2~-{[(9H-Fluoren-9-yl)Methoxy]Carbonyl}-N~6~-Methyl-L-Lysine; Fmoc-Lys(Boc,Me)-Oh; Fmoc-Lys(Me,Boc)-Oh, Aldrichcpr; N-Alpha-(9-Fluorenylmethyloxycarbonyl)-N-Epsilon-T-Buty
• CAS编号951695-85-5
• MFCD编号:MFCD01861332
• EINECS号:804-412-9
• 分子式:C27H34N2O6
• 分子量:482.57
• 产品CID: 2003960
• 产品分类有机原料→生命科学→氨基酸及其衍生物→赖氨酸及其衍生物

• 相似结构搜索
• InChIKey: JHMSFOFHTAYQLS-QHCPKHFHSA-N
• JHMSFOFHTAYQLS-QHCPKHFHSA-N…
• 计算化学: 氢键受体数5.0氢键供体数2可旋转键数9

相似化合物

物理性质

• 熔点85-87°C
• 沸点665.4±55.0°C at 760 mmHg
• 闪点356.2±31.5 °C
• 密度1.2±0.1 g/cm3
• pKa:3.88±0.21(预测)
• PSA:105.17
• LogP:5.0155
• 折射率1.566
• 蒸汽压0.0±2.1 mmHg at 25°C
• 溶解性Soluble In Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,Etc.
• 外观形态白色至类白色粉末
• 储存条件-20°C
• 产品应用该化合物用作浸硫化物合成.

MSDS等安全信息

• GHS象形图
• GHS符号GHS09;
  注释: Environment
• 危险类别水生急性毒性 类别1
  水生慢性毒性 类别1
• 警示词Warning(警告)
• 危险描述H400 |对水生生物毒性极大.
  H410 |对水生生物毒性极大并具有长期持续影响.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• 危险品标志Xi
• WGK GermanyWGK 2 water endangering

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 Fmoc-Lys(Boc)(Me)-Oh 主要起始原料 Di-Tert-Butyl Dicarbonate And Benzenebutanamide, N-8-Quinolinyl-
• 24424-99-5 + 951695-86-6 = 951695-85-5
  反应条件:1.1 Solvents: Tetrahydrofuran; 4 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 5 - 6
  标题:Preparation Method Of N-Butyloxycarbonyl-N-Fluorenylmethyloxycarbonyl-N-Methyl-Lysine
  参考文献:China]
  
  82911-69-1 + 1238313-29-5 = 951695-85-5
  反应条件:1.1 Reagents: Cobalt Dichloride Hexahydrate Catalysts: Aminoacylase Solvents: Water; Ph 71.2 Solvents: 1,4-Dioxane; Ph 101.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3
  标题:Convenient Preparation Of N-Methyl-L-Lysine And Incorporation To Histone Tail Peptides
  作者:Hongfang,Chi; Islam,Shahidul Md.; Kipassa,Nsiama Tienabe; Kato,Tamaki; Nishino,Norikazu
  参考文献:Peptide Science 日期:2010 卷标:46 页码:137-140]
  
  24424-99-5 + 909031-03-4 = 951695-85-5
  反应条件:1.1 Reagents: Triethylamine,Hydrogen Catalysts: Palladium Solvents: Dichloromethane; Rt
  标题:Concise Preparation Of Nα-Fmoc-Nε-(Boc,Methyl)-Lysine And Its Application In The Synthesis Of Site-Specifically Lysine Monomethylated Peptide
  作者:Huang,Z.-P.; Du,J.-T.; Su,X.-Y.; Chen,Y.-X.; Zhao,Y.-F.; Et Al
  参考文献:Amino Acids 日期:2007 卷标:33(1) 页码:85-89]
  
  1823167-81-2 = 951695-85-5
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; Rt
  标题:Analysis Of Jmjc Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues
  作者:Langley,Gareth W.; Brinkoe,Anne; Munzel,Martin; Walport,Louise J.; Schofield,Christopher J.; Et Al
  参考文献:Acs Chemical Biology 日期:2016 卷标:11(3) 页码:755-762]
  
  1190081-84-5 + 82911-69-1 = 951695-85-5
  反应条件:1.1 Reagents: Sodium Carbonate Solvents: 1,4-Dioxane,Water; Overnight,Ph 10,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2 - 3
  标题:A Convenient Preparation Of Nε-Methyl-L-Lysine Derivatives And Its Application To The Synthesis Of Histone Tail Peptides
  作者:Chi,Hongfang; Islam,Shahidul Md.; Nsiama,Tienabe K.; Kato,Tamaki; Nishino,Norikazu
  参考文献:Amino Acids 日期:2014 卷标:46(5) 页码:1305-1311]
  
  24424-99-5 + 909031-03-4 = 951695-85-5
  反应条件:1.1 Reagents: Hydrogen,Diisopropylethylamine Catalysts: Palladium Solvents: Dichloromethane; Overnight,Rt
  标题:2,2'-Bipyridine And Hydrazide Containing Peptides For Cyclization And Complex Quaternary Structural Control
  作者:Hernandez,Erik T.; Escamilla,P. Rogelio; Kwon,Sang-Yop; Partridge,Jonathan; Mcveigh,Matthew; Et Al
  参考文献:New Journal Of Chemistry 日期:2018 卷标:42(11) 页码:8577-8582

海关参考信息

• 2902600000-乙苯
  2905122000-异丙醇
  2905143000-叔丁醇
  2912110000-甲醛
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