CAS: 99979-77-8; 2-Chloro-5-Methoxypyrimidin-4-Amine

相似化合物

943995-31-1 695-86-3 98021-95-5

上下游产品

CAS号19646-07-2 2,4-二氯-5-甲氧基嘧啶 | CAS号219715-62-5 2-氨基-5,8-二甲氧基[1...

2,4-二氯-5-甲氧基嘧啶置于氨体系中,用 异丙醇 作为反应溶剂,化学反应生成 2-氯-4-氨基-5-甲氧基嘧啶
参考文献:发现 Trd-93 作为新型 Drak2 抑制剂
标题:发现 Trd-93 作为新型 Drak2 抑制剂
摘要:死亡相关蛋白激酶相关凋亡诱导蛋白激酶 2 (Drak2) 已成为药物开发的有前途的目标.为了寻找新型和选择性 Drak2 抑制剂基序,建立了使用内部化学库进行的体外筛选激酶测定.经过命中分类程序,N 2-(3,5-二氯苯基)-5-氟-N 4-甲基嘧啶-2,4-二胺(1)被选为具有结构新颖性和药物相似性的初始命中.在命中验证期间,彻底揭示了 1 的构效关系,Trd-93最终被验证为 Drak2 抑制的命中.trd-93很小 (Mw = 290) 但对 Drak2 (Ic 50 = 0.16 μm)超过其他激酶,包括 Dapk 家族激酶.还讨论了trd-93与 Drak2的分子结合模型研究.
DOI:10.1002/bkcs.12680

专利信息

专利号:WO-2023245611-A1
优先权日:2022-06-24
标题 :Small molecule compound with ttk inhibitory activity, preparation method therefor, and use thereof
发明人：MU BO
权利人:WEST CHINA HOSPITAL OF SICHUAN UNIV
摘要:The present invention belongs to the field of organic synthesis medicines, and particularly relates to a small molecule compound with TTK inhibitory activity. The general formula of the small molecule compound is shown in formula (I). The small molecule compound with TTK inhibitory activity can be used as a kinase inhibitor targeting TTK, proving that the compound can inhibit the activity of TTK. The compound can be used as an inhibitor for TTK activity and thus be used as a medicament for treating cancers caused by abnormal activation or high expression of TTK, has a good medicinal potential, and provides a new potential choice for clinical medication.

专利号:CN-109415319-A
优先权日:2016-05-19
标 题 :Synthesis of Aryl Carboxylate by Direct Suchuki Coupling

专利号:EP-3458442-B1
优先权日:2016-05-19
标题:Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling