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专利信息

专利号:US-10179929-B2
优先权日:2014-06-26
标 题 :Water-soluble activatable molecular probes, intermediates for the synthesis thereof and associated detection methods
发明人：HASSERODT JENS; PROST MAXIME
权利人:ECOLE NORMALE SUPERIEURE LYON; UNIV CLAUDE BERNARD LYON; CENTRE NAT RECH SCIENT
摘要:The invention provides probes with formula (I): n nin which:n X 1 â•?NH, O, or S; X 2 â•?O or S; SE is a labile group, which may be eliminated under the action of a stimulus that may in particular be the presence of an enzyme, a chemical compound, or a physicochemical characteristic of the medium in which the probe is located; A is an aromatic group that, following cleavage of the C(X 2 )—O bond in aqueous solution, leads to the liberation of a chromophore or a fluorophore, R represents a hydrogen atom or -(L)n-GP, in which n is equal to 0 or 1, L is a linker arm, and GP is a hydrosolubilizing group; as well as their physiologically acceptable salts, solvates, or hydrates. The invention also provides intermediates for the synthesis thereof and detection methods employing them.

专利号:US-2008081082-A1
优先权日:2000-11-21
标题:Topical Skin Compositions, Their Preparation, and Their Use
发明人：ZIMMERMAN AMY C; DEPPA DEBRA J; O'TOOLE DEBORAH A; MAYNE JAMES R
权利人:ACCESS BUSINES GROUP INTERNAT
摘要:Topical skin compositions include a complex containing components to provide a defense against the various pathway mechanisms of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. The compositions may be administered by topically applying them in an amount to inhibit those mechanisms. The compositions and methods are directed to the prevention of the adverse or detrimental effects of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. Thus, the compositions according to the invention improve barrier function, inhibit elastase and collagenase, and/or promote synthesis of collagen and elastin.

专利号:US-2008124409-A1
优先权日:2000-11-21
标题 :Topical Skin Compositions, Their Preparation, and Their Use
发明人：ZIMMERMAN AMY C; DEPPA DEBRA J; O'TOOLE DEBORAH A; MAYNE JAMES R
权利人:ACCESS BUSINESS GROUP INT LLC
摘要:Topical skin compositions include a complex containing components to provide a defense against the various pathway mechanisms of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. The compositions may be administered by topically applying them in an amount to inhibit those mechanisms. The compositions and methods are directed to the prevention of the adverse or detrimental effects of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. Thus, the compositions according to the invention improve barrier function, inhibit elastase and collagenase, and/or promote synthesis of collagen and elastin.

专利号:WO-2009058613-A1
优先权日:2007-11-01
标 题 :Methods for stimulating synthesis of pro-collagen or collagen and hyaluronic acid

专利号:US-2021163451-A1
优先权日:2018-05-16
标题:Methods and compositions for substituted 2,5-diketopiperazine analogs
发明人：DING YOUSONG; JIANG GUANGDE
权利人:UNIV FLORIDA
摘要:Thaxtomins are phytotoxic secondary metabolites produced in plant pathogenic Streptomyces strains and have received considerable interests as bioherbicides. A cell-free, biocombinatorial approach was developed to produce a thaxtomin library for herbicide development. Combination of biosynthetic enzymes led to the production of 136 substituted 2,5-diketopiperazines, thaxtomin D, thaxtomin B and thaxtomin A analogs in a single pot. Furthermore, rational engineering of TxtA allowed the synthesis of azido-containing thaxtomin analog. Selected unnatural thaxtomins demonstrated improved herbicidal activities. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-2009117211-A1
优先权日:2007-11-01
标 题 :Compositions and methods for stimulating synthesis of pro-collagen or collagen and hyaluronic acid