CAS: 161950-10-3; 4-Chloro-3-Methylphenylboronic Acid

相似化合物

445303-11-7 1056475-86-5 2354338-14-8

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CAS号121-43-7 硼酸三甲酯 | CAS号116632-41-8 2-氯-5-碘甲苯

硼酸三甲酯,2-氯-5-碘甲苯置于magnesium体系中,化学反应生成4-氯-3-甲基苯硼酸
参考文献:Substituted 2-Phenylpyridines
标题:Substituted 2-Phenylpyridines
摘要:替代的2-苯基吡啶化合物i,其中r.Sup.1,R.Sup.3 = H,卤素,烷基,卤代烷基,烷氧基烷基,烷氧基,烷氧基烷氧基,羟基,卤代烷氧基,烷基羰氧基,卤代烷基羰氧基,硫氢基,烷硫基,烷烯基硫醚基,烷烯基砜基,卤代烷硫基,卤代烷烯基砜基,卤代烷烯基砜醚基,甲醛基,氰基,羧基,烷氧羰基,烷氧基烷氧羰基,卤代烷氧羰基,烷基羰基,卤代烷基羰基,烷氧基烷基羰基,酰胺基,烷基氨基羰基,二烷基氨基羰基,吡咯烷基羰基,哌啶基羰基,吗啉基羰基,硝基,氨基,烷基氨基,二烷基氨基,吡咯烷基,哌啶基,吗啉基,烷基羰胺基,卤代烷基羰胺基,烷基砜酰胺基;R.Sup.2 =卤素,氰基,硝基,烷基,卤代烷基,烷氧基,卤代烷氧基,烷硫基,卤代烷硫基;或者r.Sup.1 +r.Sup.2 或r.Sup.2 +r.Sup.3 =三甲亚基或四甲亚基链;R.Sup.4 =卤素,烷基,卤代烷基,烷氧基烷基,烷氧基,烷氧基烷氧基,羟基,卤代烷氧基,烷基羰氧基,卤代烷基羰氧基,硫氢基,烷硫基,烷烯基硫醚基,烷烯基砜基,卤代烷硫基,卤代烷烯基砜基,卤代烷烯基砜醚基,甲醛基,氰基,羧基,烷氧羰基,烷氧基烷氧羰基,卤代烷氧羰基,烷基羰基,卤代烷基羰基,烷氧基烷基羰基,硝基,氨基,烷基氨基,二烷基氨基,吡咯烷基,哌啶基,吗啉基,烷基羰胺基,卤代烷基羰胺基,烷基砜酰胺基;R.Sup.5 =氢或卤素;R.Sup.6 =卤素,氰基,硝基,羟基,三氟甲基,C.Sub.1-C.Sub.6-烷基,C.Sub.1-C.Sub.4-烷氧基;R.Sup.7 =各种基团;化合物i的n-氧化物和i的农业可利用盐,其中存在的化合物i除外,其中r.Sup.2为c.Sub.1-C.Sub.4-烷氧基,R.Sup.1和/或r.Sup.3为羧基或其盐,酯或酰胺.

专利信息

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.