CAS: 169555-95-7; Fmoc-4-Pal-Oh

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上下游产品

CAS号1397697-82-3 N-fluorenylmeth... | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号37535-49-2 L-3-(4-吡啶基)-丙氨酸 | CAS号102913-23-5 (4Z)-2-methyl-4... | CAS号872-85-5 4-吡啶甲醛 | CAS号746672-87-7 FM°C-3-(4-PYRID... | CAS号111759-54-7 N-acetyl-4 pyri... | CAS号1956-21-4 3-(4-吡啶基)-DL-丙氨酸

N-Fluorenylmethyloxycarbonyl-4-Pyridylalanine-Methyl Ester置于ammonium Hydroxide,α-Chymotrypsine,Ammonium Acetate体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应 2.0H,以40%的收率获得fmoc-3-(4-吡啶基)-L-丙氨酸
参考文献:Chemoenzymatic Routes To Enantiomerically Pure 2-Azatyrosine And 2-,3-And 4-Pyridylalanine Derivatives
标题:Chemoenzymatic Routes To Enantiomerically Pure 2-Azatyrosine And 2-,3-And 4-Pyridylalanine Derivatives
摘要:Enantiomerically Pure 2-,3-Or 4-Pyridylalanine (Pya) And 2-Azatyrosine (Azatyr) Are Known To Present Various Biological Activities. After Incorporation Into Appropriate Peptide Sequences,These Heterocyclic Non Natural Alpha-Amino Acids Could Behave As New Substrates Or Inhibitors Of Elastase From Pseudomonas Aeruginosa. This Enzyme Is Known To Be Involved In Nosocomial Infections And Infections Related To The Cystic Fibrosis Disease. New Efficient Chemoenzymatic Preparations Of Those Compounds Using Alpha-Chymotrypsin (Alpha-Ct) Are Presented.
Doi:10.1007/s00726-010-0829-3

专利信息

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.